Conserved Protein Domain Family
TFIIE-A_C

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pfam11521: TFIIE-A_C 
C-terminal general transcription factor TFIIE alpha
TFIIE is compiled of two subunits, alpha and beta. This family of proteins are the C terminal domain of the alpha subunit of the protein which is the largest subunit and contains several functional domains which are important for basal transcription and cell growth. The C terminal end of the protein binds directly to the amino-terminal PH domain of p62/Tfb1 (of IIH) which is involved in the recruitment of the general transcription factor IIH to the transcription preinitiation complex. P53 competes for the same binding site as TFIIE alpha which shows their structural similarity. Like p53, TFIIE alpha 336-439 can activate transcription in vivo.
Statistics
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PSSM-Id: 402908
View PSSM: pfam11521
Aligned: 27 rows
Threshold Bit Score: 78.0963
Threshold Setting Gi: 72153499
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002187396 356 SESETSESEEESPPHPAATATTTYG----------------LEEEEEDEEfevvAEDPTVTVAGRPHSYSQVSQRPELVA 419 zebra finch
POI19824     117 agSDTESEVTKHSSTVITKLAGS------------------NSEQEEEQE----ALDPILMVAGQPYSYGEISENPELVS 174 Chinese bamboo-...
XP_016153154 427 sYSDNSGFEEDAKHSRGEGMKVAGs----------------NFEQEEEQE----TLDPILMVAGQPCFYGEVSENPELVS 486 Collared flycat...
XP_790549    342 NESDASASDDEYSQPQGRTEPPLSEdrlafgtmmgdvtmgrHEEEEEEEE------DMIVMVQGRPVPLDEVT--PEMIS 413 purple sea urchin
XP_002597179 338 SDSDSSKSDTEDSNNFFGMMAQPGIssans------qeveeMQDEDDEEE-----DVPMVTVGGVEYPYHQVSERPDLIA 406 Florida lancelet
XP_002433429 332 DSSDSEDGHGNSKTSVSSHVFSPPDalstmpeqtqdaqseeEDDDEEEEE-------TQVMVEGVPVALQHVTE--EMVS 402 black-legged tick
Q2LZ72       349 NSSDSSDDEKDIDNAKIPDLDFENys--------------nSDSEEEADD------VPTVSVAGRPHPLDQLDD--KLIA 406 Drosophila pseu...
XP_002068111 350 SDANSSDDEKEISNAKKPDLDSEDDny------------inSDSGDDGDD------VPTVLVAGRPQPLDQIDD--KLIA 409 Drosophila will...
XP_004931875 341 eSSDSSDNESKDPYKLKDELAAva----------------eMESDDSDSD----DNAPSVMVNGKTVPLTSVDD--DVIA 398 domestic silkworm
EDO37785     342 SSSSDSDSEKASNATAPTHDKVTDFmd-------------aADSDDEEEE-------HKIKVNGKVVALGDVTD--DMMK 399 starlet sea ane...
XP_002187396 420 QMTPEEKEVYIAMGQRMFEDMFD 442 zebra finch
POI19824     175 LMTNEEREAYIKVGQEMFQSVFE 197 Chinese bamboo-partridge
XP_016153154 487 LMTNEERDAYIKVGQEIFQSVFE 509 Collared flycatcher
XP_790549    414 EMDQEEKDEYIRLAQQAHADMYE 436 purple sea urchin
XP_002597179 407 QMTSGEKEAYMKIGQQYYAHLYD 429 Florida lancelet
XP_002433429 403 RMTPAEKEDYIRLRQELYSMMYD 425 black-legged tick
Q2LZ72       407 QMTPQEKENYIHVYQQHYSHIYD 429 Drosophila pseudoobscura
XP_002068111 410 QMTPQEKENYIHVYQQHYSHIYD 432 Drosophila willistoni
XP_004931875 399 QMTPTEKETYIQIYQEYYSHMYD 421 domestic silkworm
EDO37785     400 LMSPEEEEAYHKAFEQAYSHMY- 421 starlet sea anemone
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