Conserved Protein Domain Family
Lge1

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pfam11488: Lge1 
Transcriptional regulatory protein LGE1
This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B. This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters. In S. pombe the equivalent protein to Lge1 appears to be Shf1. In human, periphilin acts a transcriptional co-repressor and regulates cell cycle progression.
Statistics
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PSSM-Id: 402888
View PSSM: pfam11488
Aligned: 42 rows
Threshold Bit Score: 59.9422
Threshold Setting Gi: 754414925
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9UUI2        66 SPYHYRVPSNNstrasfgaASTDtnvelpKinlpdsSLSSKLQSCKSACENSSQSLLNVEQQYAQQVHFWEKIRTDIYRE 145 Schizosaccharom...
XP_003496748 332 ERTELVDDQLT---------NRL------K------AIASKTKEIEQAYHQDCETFGMVVKMLVDKDPSLEKSIQFALRQ 390 Chinese hamster
Q9CZ70       229 DHTEFIDDQVT---------NRR------K------AIVSKTKEIEQAYYQDCETFGMVVKMLVEKDASLERPIQFALRQ 287 house mouse
XP_012814208 210 GISEFHDANPH--------ISRS------R------AIAAKTKEIEEVYRQDCETFGMVVKMLIDKDPTLEKQIQFALRQ 269 tropical clawed...
XP_005993234 275 ELLRPIEESKA--------DHRS------A------VIAAKTKEIEQVYKQDCETFGMVVKMLIDKDPSLEKPIQFALKE 334 coelacanth
XP_007579001 263 EDSKKSTENLE--------ERRT------M------AIAAKAKEIEKVYRQDCETFGMVVKMLVAKDPSLEKQLQVPLRE 322 Amazon molly
Q5SP53        75 EASSVMDDFQE---------RRA------Q------AIAAKAREIEKVYRQDCETFGMVVKMLVSKEPSLEKHLQNPLKE 133 zebrafish
XP_015194481 270 DTTTFLNDDFQ--------ERRA------I------AIAEKAREIEQVYRQDCKTFGMVVKMLVAKDPTLEKQLQTPLKE 329 spotted gar
ELK02220     322 DGIELFEDGRL--------SSRY------K------AIAAKTKMIEQVYQQDCETFAMVVKMLVEKDPSLEKPIQFALRQ 381 black flying fox
ELW48705     108 DGIELFEDGQL--------TNRS------K------AIGLKTKEREQAYQQGCETFGMVVKILIEKDSSLEKPIQFALRQ 167 Chinese tree shrew
Q9UUI2       146 GLRSda--avKSLNDFV 160 Schizosaccharomyces pombe 972h-
XP_003496748 391 NLHEisercvKELRQFI 407 Chinese hamster
Q9CZ70       288 NLHElsercvEELRQFI 304 house mouse
XP_012814208 270 NLSEigerciEELKMYI 286 tropical clawed frog
XP_005993234 335 NLNDigdrciEELKRFI 351 coelacanth
XP_007579001 323 NLGEirerclEDLKHFI 339 Amazon molly
Q5SP53       134 NLIEirerclEDLQHFI 150 zebrafish
XP_015194481 330 NLIEirerclEDLQQFI 346 spotted gar
ELK02220     382 NLYEmgqrcvEELKHFI 398 black flying fox
ELW48705     168 NLHEmgerciEELKHFI 184 Chinese tree shrew
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