2XLQ


Conserved Protein Domain Family
PTase_Orf2
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pfam11468: PTase_Orf2 
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Aromatic prenyltransferase Orf2
In vivo Orf2 attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-derived polyketide during naphterpin biosynthesis. In vitro, Orf2 catalyzes carbon-carbon based and carbon-oxygen based prenylation of hydroxyl-containing aromatic acceptors of synthetic, microbial and plant origin.
Links
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Statistics
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PSSM-Id: 371546
Aligned: 6 rows
Threshold Bit Score: 369.147
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2XLQ_A        13 FDCERFRADIRATAAAIGAPIAHRLTDTVLEAFRDNFAQGATLWKTTSQPg--DQLSYRF-FSRLKMDTVSRAIDAGLL- 88 
XP_002143864  72 FNAEHFKQDVSELCTTLNADYNEGVMNAVLNTYKENFERGAVLWKATSKE---DGVAFRF-YERKKVDVVGPAINNSLI- 146
EST35512      10 FDCERFRADIRATAAAIGAPIAHRLTDTVLEAFRDNFAQGATLWKTTSQPg--DQLSYRF-FSRLKMDTVSRAIDAGLL- 85 
CCK32327       7 vSVAGFYSAIEKSAGLLDVTASREAVWPILTAFEDALPHAVIAFRVATNArheGDFDARFtLPKE-IDPYEVAVSKGLMa 85 
Q9FBZ2         7 TDLALFLSDLEAYAKLAEVTFDKRAVEQVVDVFAEQFATGTITVRTTTHEaanRSVNFRYmYPDSPHDPVEIARAHGLLp 86  Streptomyces co...
XP_001589743  12 FSQSRFLDDIRNLSAAINAPYSERTTIEALSVYSHSFHNGVVLWRVTDRPg--DALNYRF-YSREPIDTVSIAASAGLLs 88 

2XLQ_A        89 -DAAHPTLAVVDA-------WSSLYGGAPVQs--GDFDAGRGMAKTWLYF--GGLRPAE--DILTVPALPASVQARLKDF 154
XP_002143864 147 -SGNHGMIPLITS-------WANFKKNAIAS---CDFDPAKGLCKTWIWL--GGRHPTR--DLLVAPNVPGTIRSLERKL 211
EST35512      86 -DAAHPTLAVVDA-------WSSLYGGAPVQs--GDFDAGRGMAKTWLYF--GGLRPAE--DILTVPALPASVQARLKDF 151
CCK32327      86 -KTDHPIGSLLAD----------LQQLCPIDsygIDFGVTSGFKKIWVYFpaGEHETLE--RLTGLASMPRSLAQNLEFF 152
Q9FBZ2        87 -DADPAVMSLLAEvtekiplWWGL-----------DASVGHGVQKVWAFF----EQPLEfgEIASLENTPHSLRDHRERF 150 Streptomyces co...
XP_001589743  89 pDIANTLGKLVTS-------WSSLYDGTPEEs--CDFDAEKGLVKAWVYF--GGMRPLD--DILGAEGVPESVRQHEKRF 155

2XLQ_A       155 LALGL-AHVRFAAVDWRHHSANVYFRGKGP--LDTVQFARIHALSGSTPPAahvvEEVLAYMPE-----DYCVAITLDLH 226
XP_002143864 212 ISAGL-HTVRHAAVDWRSSTVNLYFWVPRP--LTLPVVNTLITLPGTPPIN----EEKLTLMKPffkpnGFTFATTIDTA 284
EST35512     152 LALGL-AHVRFAAVDWRHHSANVYFRGKGP--LDTVQFARIHALSGSTPPAahvvEEVLAYMPE-----DYCVAITLDLH 223
CCK32327     153 TRHGLaDKVDVIGIDYRSRTMNAYLRAPAEc-YERESVLTMHRELGLPSPS----EQMFAFCEK-----AFGIYTTHNWD 222
Q9FBZ2       151 GEARI-DRFAIMGFDFRDNTTNLYSEMVSPgyFEQEEVARMIRDVGSLPPD----NEEIERCRG-----AINVYYTFDWN 220 Streptomyces co...
XP_001589743 156 KELGL-QKVRHVAVDYHKQTVNLYFRAQGP--ISFQQATAFNALAGAEPPS----QSQFIEMREflnavGYTFAVTINID 228

2XLQ_A       227 SGDIERVCFYALKVPKNA---LPRIPTRIARFLEVAPSHDVEECNVIGWSFG----RSGDYVKAERSYTGNMAEILAGW 298
XP_002143864 285 TGKFKRVSFYALRLDGNN---LPIMGDQLATFFKDAPSNDKTEMNIVAWSFAggsnGSSNYIKGERSYIGDLEQVLDAW 360
EST35512     224 SGDIERVCFYALKVPKNA---LPRIPTRIARFLEVAPSHDVEECNVIGWSFG----RSGDYVKAERSYTGNMAEILAGW 295
CCK32327     223 SPEIERISYGVKT--ENPmayFARLGTKIEHFVQSVPYGVNDPKMVYAAVTS----TGEEYYKLQSYYRWRSVSRLNAA 295
Q9FBZ2       221 SPQARRLCF---AVPSRDgefPSHLHPLAARFAAEAPVQAERRELIFNPTFG----ARGSYLKMEADYTGDAASRVFGY 292 Streptomyces coe...
XP_001589743 229 SGDIERVGYYALKLPERSakkWPAINAQLERFVQFAPSYDREEMNAVAWSFG----ERKTYVKFERSYCGELIPLIKGW 303
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