6EMQ


Conserved Protein Domain Family
LEDGF

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pfam11467: LEDGF 
Lens epithelium-derived growth factor (LEDGF)
LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure.
Statistics
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PSSM-Id: 402877
View PSSM: pfam11467
Aligned: 33 rows
Threshold Bit Score: 94.3045
Threshold Setting Gi: 215504148
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EMQ_A         11 DSRLQRIHAEIKNSLkiDNLDVNRCIEALDELASL--QVTMQQAQKHTEMITTLKKIRRFKvsQVIMEKSTMLYNKFKNM 88  
XP_015221290  476 EEKLQKLHTDIKFALkvDNPDVQRCLQALEELGSV--QVTSQILQKNTDVVATLKKIRRYKasSEVMEKATQVYNKLKLQ 553  spotted gar
NP_001002037  479 EEKLQKLHTDIKFALkvDNPDIEKCLQALDELSSV--QVTTHILQKNADVIATLKKIRRYKasNAVMEKATAVYNKLKLQ 556  zebrafish
CAG07956      471 EEKVQKLHTDIKFALkvDNPDIERCLQALEELEAV--PVTSQILQRNAEVIATLKKIRRYKasAAVMEKASDVYNKLKLR 548  spotted green...
XP_005993830  577 gERLQKLHSDIKHALkvDNPDIKKCLECLEELGGL--QVTSHVLQKNTDLVATLKKIRRYKasKEVMDKATQVYNHLKLQ 654  coelacanth
OCA49057      501 EEKLQKLHSEIKFALkvDNPDIQKCLDALEELGGL--QVTSQILQKNTDVVATLKKIRRYKanQSVMDKAAEVYSRIKAR 578  tropical claw...
ELK19411       34 EEKLQKLHSEIKFALkvDNPDVKRCLNALEELGTL--QVTSHILQKNTDVVATLKKIRRYKanKEVMEKAAEVYTRLKSR 111  black flying fox
EEC13642       53 EKRISELDKDIKNNLgvSGKDVDAALKALDEVDKL--PLTQSLLRKEQEILYTVKKCSKFTgdDRIKKKAEYLYHKFKNI 130  black-legged ...
XP_011673625  523 EEKIENFHVNLKQSLalDNPEPARSLQIMANIDQImdRLTPSLLKKHVDFVQTIKKVRKFKssDAVRKKAEYLYNKLKLV 602  purple sea ur...
XP_031163054  478 EEKLQKLHTDIKFALkvDNPDIDRCLQALDELAAV--PVTSQILHKNAEVIATLKKIRRYKasNAVMEKASEVYNKLKLR 555  pike-perch
6EMQ_A         89 FLVGEGDSVITQVLNK 104 
XP_015221290  554 FL-GKAEGVLKQKLET 568  spotted gar
NP_001002037  557 FI-GKIE-TGKPKPNE 570  zebrafish
CAG07956      549 FV-GKLDMAAKPKSEG 563  spotted green pufferfish
XP_005993830  655 FLGAKADLALKSSKPG 670  coelacanth
OCA49057      579 ILGPKLESQQKTVQKV 594  tropical clawed frog
ELK19411      112 VLGPKIEAIQKAARTG 127  black flying fox
EEC13642      131 LIVTTPEPLGATDKES 146  black-legged tick
XP_011673625  603 FLMQDSESAALLKREM 618  purple sea urchin
XP_031163054  556 FV-GKPDVAAKPQTDD 570  pike-perch
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