Conserved Protein Domain Family
Stealth_CR2

?
pfam11380: Stealth_CR2 
Stealth protein CR2, conserved region 2
Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.
Statistics
?
PSSM-Id: 402818
View PSSM: pfam11380
Aligned: 99 rows
Threshold Bit Score: 126.813
Threshold Setting Gi: 523997682
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_656279            398 RYRDYNTLQYSIRSVYNFAPYIKNYYIVTMGQIPDFLNTSSltfrDyKLRIVDHKEIFPNnKD-LPVFNSNALEVSIHNI 476  Entamo...
XP_001582220          76 RYVEKNELLLSLRTVYQFISWINKIYIVTNDQYPFWLNLSH----P-KISIISHSQ-LYG-EG-KTSFSSNSIQFTLNKI 147  Tricho...
XP_003286509          89 RYRDLMGLKYSLRSVRKYAPWIKNIWVVSASQYPTWFDETN----D-EINFIFHKDYYTN-QDdLPTFNSNSIESNFYSL 162  Dictyo...
EFA80672             397 RVRDLMGLKYSLRSIKKHVPWVRKVFVIADDQYPYWFNQSN----T-DIQFIFHQHYYKN-IShLPTYNSNSLEINFYNL 470  Hetero...
EFA80670             248 RVRDLMGLKYSLRSIKKHVPWVRKVFVVTDSQYPYWFNTSN----K-EIEFIFHKDFFKN-TShIPTFNSNGIEWNFHNL 321  Hetero...
EGG19013              89 RFRDLMGLKYSLRSLKKYAPWIRRVHVVADDQYPSWFDTNN----D-EINFIFHRDYFPN-VEdVPTFNSNGIEANFFNL 162  Cavend...
EFA79651              81 RFRDLMGLKYSLRSLKKYAPWIRRIFVVSDNQYPSWFDKSS----D-EVRFVFHKDFFLN-KEdLPTFNSNSIESNFFNL 154  Hetero...
wkYale:SALWKB2_2241   46 RYQDFGTLRYVLRSIEKNCPWYHKIYLITADQQPPWLKTSH----P-KIEIVSHRQLFIR-PQnLPVFNSSAIEMNLVNL 119  Snodgr...
WP_013554921          42 RYRDTKTLKYALRSIEKYCPWYNKIHLITNGQKPEWLNFDH----P-KINLIIHEELYFD-KThLPTFNSSSIEMNLANL 115  Nitrat...
WP_005713691          39 RYRDMGTLRYVLRSIEKNCPWYNRIYLITEGHFPEWLDINN----E-KIFLITHNQLYYE-KEhLPIFNSSSIEMNLGNI 112  Glaess...
XP_656279            477 K--NLSSCFLYLNDDMLLGKKLKPEHFCRKDGKINV 510  Entamoeba histolytica HM-1:IMSS
XP_001582220         148 P--NLANKFILADDDFFWTKPIDKSYYFTKNKLKFR 181  Trichomonas vaginalis G3
XP_003286509         163 Pk-EVSDCFIYFNDDIFFGSPVAMKDFYDPTYGQAI 197  Dictyostelium purpureum
EFA80672             471 Pd-YVSDCFLYFNDDTFVANDLPMDYIWDKEKGQAL 505  Heterostelium album PN500
EFA80670             322 Pn-SVSDCFLYFNDDTFVGNNLPIETIWNKDKGQAL 356  Heterostelium album PN500
EGG19013             163 PddQVADCFIYFNDDIFVGSPIEPKDFWDPVYGQAI 198  Cavenderia fasciculata
EFA79651             155 Pd-EVSDCFLYFNDDIFVGSPIQIKDFWDPTYGQAI 189  Heterostelium album PN500
wkYale:SALWKB2_2241  120 K--GLSEQFVYLNDDTVILRPVPRERLFQHG-LPVD 152  Snodgrassella alvi wkB2
WP_013554921         116 K--NVSEKFIYLNDDFLIFNRLTKDRFFV-DDKPVD 148  Nitratifractor salsuginis
WP_005713691         113 D--ALSENFVYLNDDMIIMRGVNKERFFFHD-KPVD 145  Glaesserella parasuis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap