Conserved Protein Domain Family
GTA_holin_3TM

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pfam11351: GTA_holin_3TM 
Holin of 3TMs, for gene-transfer release
This is a family of bacterial 3TM holins. In Rhodobacter capsulatus the protein is expressed just overlapping and downstream of a putative N-acetylmuramidase lysozyme (an endolysin) thought to be responsible for lysing a phage particle, RcGTA - a gene-transfer agent. A holin would be necessary for such an endolysin to access the peptidoglycan. Gene-transfer agents are bacteriophage-like genetic elements with the sole known function of horizontal gene transfer, serving an important role in microbial evolution. In order to be released from the cell these require the combined action of an endolysin and this holin.
Statistics
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PSSM-Id: 402795
View PSSM: pfam11351
Aligned: 23 rows
Threshold Bit Score: 76.7621
Threshold Setting Gi: 123526352
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ACL05250            9 GSVADFASSVVNRIFPEKMSEADKAQAQiklqEMLQQ----------RDDvvinakrdimvaeasqdDKWTKRARPAIIY 78  Desulfatib...
WP_015852228        3 GSILDLGSTIIDKIWPDAGEREKAKL------RLMEMqn-------rGELadlesrvk-immaemsgNWLQRSWRPILML 68  Desulfovib...
EEF26023            8 TAVTNVVGQVIDRVWPDPAQAAQAKL------QLLQLqq-------tGELaqitgqleinkaeaaneSSFVAGWRPFIGW 74  castor bean
bbmufp:Hsero_0230   7 APLLELGRTLIGKLWPDPQAQADAQF------RLLQLqqagefkeleRQLqlmlaqsdvnredarsgSNFRGGWRPFIGW 80  Herbaspiri...
jgi:Mpe_A1850       7 GFLGDAVRSVLDRVFPDPIERARAEV------ELIKAqsegt-fdqrAAQalalaqigvnnteaaspGIFKGGWRPAAGW 79  Methylibiu...
WP_012203889        7 GGIVDAIGKIADDLFTSDKERLDAQIEL----QKVSIea------akIDAslatgqmevnkaeatnaSLFVAGWRPAIGW 76  Delftia ac...
Q2G6K9              5 EALISPVSAIIDKVIPDKEARDRAKL------ELLRLeg-------sQELellrtrmsaviaeassaDPWTSRARPGFLY 71  Novosphing...
ELS:G432_06140      5 EGIFGPVAKLIDKIIPDPEARDRAKL------ELIKLeg-------gQELeavkaqlsaivaeaqsaDPWTSRARPSFLY 71  Sphingomon...
Q2NC76              5 ESLIGPVASIIDKVIPDKQARAQAKL------QLLELeg-------tQELkaiearlsaivaeaqspDPWTSRARPSFLY 71  Erythrobac...
WP_013833273        5 DSLISPISHIIDKVIPDPDARDRAKL------ELLRLen-------sQEIeklqaslsavvaeagsaDPWTSRARPSFLY 71  Novosphing...
ACL05250           79 CGLAFIFIVh------VFFPIVTKSIILGClifapeKLTPEvmaalksymdlslptAFWTAWGGAVSI--YAIGRT 146 Desulfatibacil...
WP_015852228       69 TIVAIVANNy------LLYPYLALFWAKAPh-----LELPA---------------QLWSLME--LGLggYVVGRS 116 Desulfovibrio ...
EEF26023           75 VCGAGCAWNw------IGLPVAKFALSMLG------HPVNMsaa---------dlsEMMPVLLGMLGLggL---HS 126 castor bean
bbmufp:Hsero_0230  81 VCGLGLAYQf------LLRPLANGVLAVRG------HGMPMpel---------dtnTLMALVTGMLGFggL---RT 132 Herbaspirillum...
jgi:Mpe_A1850      80 VCVGALAWQf------VARPMVAFGFAVAG------HELPElpt---------idgALWELLFGLLGLgtL---RS 131 Methylibium pe...
WP_012203889       77 VGAASMLYQf------LIYPFLVWAWALMQa----kGWVPVtmsapp----mleaeSLWVILSGMLGIasL---RT 135 Delftia acidov...
Q2G6K9             72 VMYVMILWAlplgligAFRPEAARGIAAGIna--ylNGLPE---------------PLYALFG--TGYlgYTAARQ 128 Novosphingobiu...
ELS:G432_06140     72 VMYALLLWSipmgiisAAQPALGSAIAKAMna--ylAGLPE---------------PLYALFG--TGYlgYTVARE 128 Sphingomonas s...
Q2NC76             72 VMYVILLFAlpmgliaAVSPASATAIATGIna--ylNGLPE---------------PLYALFG--TGYlgYTAARQ 128 Erythrobacter ...
WP_013833273       72 VMYAMILWAlpmgligAFSPSTAQAIATGMta--ylRGIPE---------------PLYALFG--TGYlgYSAMRQ 128 Novosphingobiu...
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