Conserved Protein Domain Family
Tho2

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pfam11262: Tho2 
Transcription factor/nuclear export subunit protein 2
THO and TREX form a eukaryotic complex which functions in messenger ribonucleoprotein metabolism and plays a role in preventing the transcription-associated genetic instability. Tho2, along with four other subunits forms THO
Statistics
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PSSM-Id: 402722
View PSSM: pfam11262
Aligned: 120 rows
Threshold Bit Score: 160.475
Threshold Setting Gi: 121975976
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERT02556     1323 KRISPEFFVTFWALQQGDIVVPRARYDAEIDRLRKESSAL---------------------------KNARgvqgTENpr 1375 Sporothrix sc...
EEC50030      905 DYISTTLFEIFYTKSLYDLFCPEEVYASEIARLEKEGERFaiqk-------------------daspSTSV----QPGna 961  Phaeodactylum...
EED91330     1200 KHISLELFEAFHSFSVYDIVCPEERYNSEIGRLKKEVESLtqlqkggdaargamasmaasmaaaggtDEQI----RRSta 1275 Thalassiosira...
XP_001614024 2037 NGINIDFYLTYWRLSITDIYVPHKQYQKVIERYDAYIKKLe-------------------------kHHEE----NKKne 2087 malaria paras...
Q8I4T6       2413 NGININFYLTYWRLSISDIYVPHKQYQKVLDKYENYIKKLe-------------------------kYYEE----NKKnd 2463 Plasmodium fa...
XP_001608714 1048 DTFKPEFMKFIWSIHLSDVWVPIEQYEKTLQRLNAWIAES-------------------------------------Esn 1090 Babesia bovis...
Q4N3V4        402 TMLDDNFVGFINSLSIYDIYSPTEQYDTYVSKLTSFLSTIt-------------------------tAGAG----NT--- 449  Theileria parva
Q4UFM1       1521 NILDDNFIGFINNLNIYDIYTPVEQYDNYITKLTS---------------------------------GIG----NT--- 1560 Theileria ann...
A0BH94        916 TIINPELFAIFWLLSLDNIYVPQAIYDQQLKWLQENINKNpdt------------------------------------- 958  Paramecium te...
EEY62334      908 tGLTPEVYATFWGLKLYDIHIPFQQYESEILRLRNSVTS------------------------------------GANas 951  Phytophthora ...
ERT02556     1376 aammRrNEEAEARLKERQAIAEEMLALGTRNRDTKRHLLVHAQT-WFTnngsSSVtiASASALSDILLEQCLVPRILLSV 1454 Sporothrix sc...
EEC50030      962 p-vaSiQDEINRCETTVVKLKADLAKQKRHVAESRKTIQELAAD-LFE-----SK--TANEESATAFLTRCVFPRCMQGP 1032 Phaeodactylum...
EED91330     1276 f-tkEhAMKLDRLKHNKDQLSKDFSRQQKRCQLVHSQLKSQKDA-LIVae-eSGE--SSCGEFAPAFMTFCVYPRCFLSP 1350 Thalassiosira...
XP_001614024 2088 d-ykWvLKKLRKLRSKRGTINSEYQFHIQHTEKIKKHLSHVVDH-WVN-----PQ--EIDLTTFTAFVKCLIAPRILNSE 2158 malaria paras...
Q8I4T6       2464 e-ykWiPKQIKKLNIKKNNLKNEYEYHINHTKQIKQYLAHIVDH-WVD-----PQ--KVSLNTFVAFIKCLIAPRILNSE 2534 Plasmodium fa...
XP_001608714 1091 h-ssSgHRKLKKLRSRHAAIEQEFIKQKEHVEQTKKRFSEVVSSgWLS----ANV--QIGPAINTAFLQHCIVPRVFINE 1163 Babesia bovis...
Q4N3V4        450 ------FRRAKRIKNRITTLETDKEEHLTHSNVVLERLKEVFKS-FVK----NDA--KVGPHITTRFISRIVFSRLLVSE 516  Theileria parva
Q4UFM1       1561 ------VRRIKRIKNRITILETDKNEHIQHTNMILSHLKEVLKR-FVK----NDN--KVGPHITMRFITRIIFPRLFVSE 1627 Theileria ann...
A0BH94        959 --kdRqSKQHQKA---FDKLQNELDNNKKRQEQFDKCLRDKKHVfSFKeadqAKE--NYHIKFAQCLSQVCLLPRILIDP 1031 Paramecium te...
EEY62334      952 lsasErKKLKEKTTQMIDVLTTEQKEQVAHRKRVYERLEKMKSK-FFK----DEP--NDHQTAIDELLQKCVIPRSLMSP 1024 Phytophthora ...
ERT02556     1455 ADAEYAFRFVRFLHENRVPHFQLATFYQRLFSANrLRDLIFTSTVREAERVGRFLKLILADLARWHGDKNAYEREALgqt 1534 Sporothrix sc...
EEC50030     1033 DDALYCAHFVKFLHEIETPGFGTLYIFDVTVVS--LSRALFGMTEGEAANVSILLCEIWKVASKWRYEKDSFDTEITgkp 1110 Phaeodactylum...
EED91330     1351 EDGLFCFHFIKMLHKMKVPGFLTIELIDNIINA--ATGSFYCVTEDEAGNLAIFLNEIWKVVNTWRYDNDAFASEL---- 1424 Thalassiosira...
XP_001614024 2159 KDSLFCSKFILLLLEFRTPLFNFCLLTYVCIKM--LMPIINACTEKEALNIGLFFNELFSYAYQLCQDPKHFKL--V--- 2231 malaria paras...
Q8I4T6       2535 KDSLFCSKFIQILLELHTPLFNLCTLVYIFTKM--LMPLINACTEKEALNIGIFFNDFFSYIYLLCEDIKYFQN--V--- 2607 Plasmodium fa...
XP_001608714 1164 AEASFCSHLVDLMLLNRVECFNFFDFSNCWTKM--LMSMVRCCTEREAPLLAIFVNHAFHVIRGWIDDAEGFEA--M--- 1236 Babesia bovis...
Q4N3V4        517 LNALFCCKIVDLIMENKMNYFNYFDFVNCYTKM--LIPMISSLTEREVINLSIFFNHSFHLIKGWVNNREAFEK--L--- 589  Theileria parva
Q4UFM1       1628 LNALFCCKIVDTILENKMNYFNYFDFVNCYTKM--LIPMISSLTEREVISLSIFFNHSFQLIKAWVNDRDAFEK--L--- 1700 Theileria ann...
A0BH94       1032 AEAIYCAKFVQKMLKIGKPRYTYTFYVPKEIIYF-TFTYLQCATEEEASNLSIFMQQLIIPYANWN-DETKFKN------ 1103 Paramecium te...
EEY62334     1025 EDALFAAKFMERLHTFSTPQMSTLQYIHKVNMK--VSAIVLCATEREASNFGIFMKETLGLILRWYQNGATYDDEAIh-- 1100 Phytophthora ...
ERT02556     1535 -----knGRRSYL------GFVKNS-KAAAkpagkaaatssesaeggkdkdnkvnednedgPTYIEHTEFRDLLYSWHKN 1602 Sporothrix sc...
EEC50030     1111 csmllnkKRGSI--------------------------------------------------QPVSYAEFEVLYNRWHAA 1140 Phaeodactylum...
EED91330     1425 ---------KDTPgsrlskTFAEENnMGEHs-----------------------------iTDGVTHDDYKTLYTKWHLR 1466 Thalassiosira...
XP_001614024 2232 --------SEENPcfsstlNFQSK--------------------------------------VTIEHSFIIGKVAKWEKL 2265 malaria paras...
Q8I4T6       2608 --------SNKNPcfsytlNFQSK--------------------------------------DTITHNNIIQKVMKWEKT 2641 Plasmodium fa...
XP_001608714 1237 --------TRDHPcfcttfKFVPD--------------------------------------KALTHAQLMSGIRKWEGR 1270 Babesia bovis...
Q4N3V4        590 --------VYDNPcfcttfKFQPN--------------------------------------REFKYQQLLQVIKKWEYF 623  Theileria parva
Q4UFM1       1701 --------VYDNPcfcttfKFQPN--------------------------------------KEFKYQQLLQVIKKWEYF 1734 Theileria ann...
A0BH94       1104 -------------------DLRNYFdT-----------------------------------SIDGYDREKQYII---QN 1126 Paramecium te...
EEY62334     1101 ------gKM----------GLSLDLhDDK---------------------------------KRLAHRQFKSAYARWHKQ 1131 Phytophthora ...
ERT02556     1603 LNMALKD------------------------------------------------------------------------- 1609 Sporothrix sc...
EEC50030     1141 IGAAAIG------------------------------------------------------------------------- 1147 Phaeodactylum...
EED91330     1467 IGSASIG------------------------------------------------------------------------- 1473 Thalassiosira...
XP_001614024 2266 LVSLLFE------------------------------------------------------------------------- 2272 malaria paras...
Q8I4T6       2642 ILSLLFE------------------------------------------------------------------------- 2648 Plasmodium fa...
XP_001608714 1271 IMRALSYalvlnitd----------------------------------------------------------------- 1285 Babesia bovis...
Q4N3V4        624 ILLSIFSinkpptstnsansansansttsassv----------------------------------------------- 656  Theileria parva
Q4UFM1       1735 ILLSIFSsvtgsgqtatninkvnstnnsnsikdssstvvtsnkdstsnkvnsstvvtstsntkstttsnkdsntkdskan 1814 Theileria ann...
A0BH94       1127 IFFKMAQ------------------------------------------------------------------------- 1133 Paramecium te...
EEY62334     1132 LELVYTT------------------------------------------------------------------------- 1138 Phytophthora ...
ERT02556     1610 ------------------------------------------------CL--ENLEWTHIRNAISVLKAVMDAFPAVDFM 1639 Sporothrix sc...
EEC50030     1148 ------------------------------------------------CL--QSSEYIHTRNCLIVLKRMVEVYPTRPRL 1177 Phaeodactylum...
EED91330     1474 ------------------------------------------------CL--KSSEYMYTRAALIVLSRIVLVYPTQPKV 1503 Thalassiosira...
XP_001614024 2273 -------------------------------------------------NnnHQKSWINSKSVVIFLFRVLHSFPYSNKV 2303 malaria paras...
Q8I4T6       2649 -------------------------------------------------NnnFEKSWINSKSVVIFLFRFLNTFPYSHKI 2679 Plasmodium fa...
XP_001608714 1286 ----------------------------------------adssgeagAPevVAPTWIDQKGAIVFLARCHENFPITIAA 1325 Babesia bovis...
Q4N3V4        657 -----------------------kddkgrvgdlknsaesemasepesvLP--QKRSWIEIKNVVIFLNKVSSNFPITVNS 711  Theileria parva
Q4UFM1       1815 kdtnsikgapfgagnkdskstsstmgstmgtttgtagastvtgtvtdeSP--IVQSWIEIKNVIIFLNKVSNNFPITINS 1892 Theileria ann...
A0BH94       1134 ------------------------------------------------FIriLKNNETQVRNALIFLKRVQDIFPPTQQV 1165 Paramecium te...
EEY62334     1139 ------------------------------------------------AL--SSGEYMPIRNSLVVLTKLIDVFPAGRGT 1168 Phytophthora ...
ERT02556     1640 GRQFADQ---LQRIAARESatnnatpeasqRIDLSVTARAIYSEL 1681 Sporothrix schenckii ATCC 58251
EEC50030     1178 GNELLEA---LVPLQDEGNk----------FADIRASAQAFSTQL 1209 Phaeodactylum tricornutum CCAP 1055/1
EED91330     1504 GDKILDT---LTSLQGEDNp----------RPDIRATAQGYSSQL 1535 Thalassiosira pseudonana CCMP1335
XP_001614024 2304 KHSIRKYlqnLHSFAQSRG-----------WKDIAISVNSL-KTI 2336 malaria parasite P. vivax
Q8I4T6       2680 KNSIKTYlenLQNFANNQG-----------WKDIVISINSL-KTM 2712 Plasmodium falciparum 3D7
XP_001608714 1326 GKRVLNGlngVVVNAEQKG-----------WKDVVVAAKTLVKTF 1359 Babesia bovis T2Bo
Q4N3V4        712 SLKVLNFlknVLKLAKQNN-----------WQDVTVPSNTLIKLI 745  Theileria parva
Q4UFM1       1893 SLKVLNFlknVLKLAKQNN-----------WQDVTVSSNTLIKLI 1926 Theileria annulata
A0BH94       1166 AEYIKIY---LQDVEKDYGh----------IQDIKTQIKNFhied 1197 Paramecium tetraurelia
EEY62334     1169 ADVILVI---VEKLTSED------------REDIKIMAKRYFALL 1198 Phytophthora infestans T30-4
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