2KY6


Conserved Protein Domain Family
Med25

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pfam11232: Med25 
Mediator complex subunit 25 PTOV activation and synapsin 2
Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear.
Statistics
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PSSM-Id: 402699
View PSSM: pfam11232
Aligned: 20 rows
Threshold Bit Score: 160.96
Threshold Setting Gi: 1133458452
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2KY6_A        13 LAWSGVLEWQEKpkpasvDANTKLTRSLPCQV---YVNHGE-NL--KTEQWPQKLIMQLIPQQLLTTLG--PLFRNSRMV 84  
XP_009008966 444 IIWTGPLEWTDKl----kNQSVKITRTLPCQI---NINQDEpEI--NTSKWPEKLTMSIFPPSVIQPLQ--HLFRSSRTV 512  Helobdella rob...
XP_014309200 247 LAWSGVLEWKEKfk---pGTNIPLMRSLPCQV---YVDHGE-NL--KTDLWPQKLIMNLFPSQLLIPLG--HYIRNSRRV 315  little brown bat
XP_001627984 394 LAWSGTLEWYETtrt-dlTTPTRITRSLQCHI---SVAPQN-AI--KTDKWPSKLIMQLIPQHLLSTLG--RLLQNCKTV 464  starlet sea an...
EKC40435     191 IIWQGILEWQEKmka-ggPQTPKVNRQLQCHL---SIGQADpDI--NAMNWPKVLIMQLIPQSLLNSTQlqPLFKNSRQV 264  Pacific oyster
EEC17382      25 TVWQGQVEYQDKm-----PGNPRNVYTLQCTVs-tSVTNGEpEV--CADKWPPKLTLQLMPKTMLMNVVl-AVKNAARCV 95   black-legged tick
XP_015783556 480 IIWNGTIEFQEKs----aQEGIPPKYSLPCSI---TSTNGSpDLekNAEKWPSMLNLSLLPRTIINAVLp-VLKNESHVV 551  two-spotted sp...
Q9VCB1       216 LLWTGSLNWSTQa----sLEEPSISHKLECSVy-iAIKNGDpGI--SAEDWPTDMPMVLMPSIYLGQFAg-AFIKDSKLI 287  fruit fly
Q9VCB1        45 TIWSGELEWEDAqi---lDQP-KTLHTVQCKIc-sMVKEGQpEI--NTENWPNKLKTQLIPKKVLGKIGe-QFLKDARMV 116  fruit fly
EDV29329     285 LIWSGLLSWE--------RHNNKVDRRSGETLsvnGYAYSNeNI--RGEDWPRQLILRFVPGNLLAEMM--PLLRKSIQI 352  Trichoplax adh...
2KY6_A        85 QFHFtn------kdLESLKGLYRIM---GNG-------FAGCVHF---PHTAPcEVRVLMLLYSSKKKIFMGLIPYDQSG 145 
XP_009008966 513 LFNFnqn-----sdTEAMNSLYRSL---SNN-------FSGCIHFsttPETSN-DIKVLMLLYSNRKQQFLGLIPYDQAN 576  Helobdella rob...
XP_014309200 316 QFSFtn------ldLESHKSLYRMI---GNG-------CGGFVHF---LFMDHsKLRIYMLLLSRKKKTFMGLIPYDQKG 376  little brown bat
XP_001627984 465 AFHFpa------tdPDSLKALYGVMamrGVK-------FAGCVHF---PPVPGcEIKVLLLIYSPKKRAFVGLIPHDQGN 528  starlet sea an...
EKC40435     265 AFHFgs------qnLDDLRNLYKVM---GTG-------FAGCVHF---PAGSQcEVRVLLLLFSNKRRAFIGLIPNDQTA 325  Pacific oyster
EEC17382      96 VLAFgggpeggpaaAEGLHKLSRFM---SSA-------WLGLVHF----ASPPaDIKLMLVVYMPDKNFYMGMIANDQET 161  black-legged tick
XP_015783556 552 VLNFanq-----dtSEIIQKLQKTI---SGGgrqpqiqFCGCINLypnQNT------MMIVIYAPDKNTFMGFLPMNQEA 617  two-spotted sp...
Q9VCB1       288 ILRStp--------gEEHDSLASSM---SAG-------SCGCARF-----SSEvVCKVIMLLYSSPRNAFLGFIPRDQAN 344  fruit fly
Q9VCB1       117 VFRSsq--------gEVLNLLITAM---SSG-------FAGCIHF---PSNPNcNIKALILIYSRDHQALVGFIPNNEDS 175  fruit fly
EDV29329     353 LFHIsm------tdNNTKNLIQTLT---QNK-------VVAFISFqgiSLNPEeKLRLLILTYNPKKN-FTGYIPRDQMD 415  Trichoplax adh...
2KY6_A       146 FVNGIRQVITNHK 158 
XP_009008966 577 FLKSIKSVIAKHK 589  Helobdella robusta
XP_014309200 377 FLNRMGQIVRREl 389  little brown bat
XP_001627984 529 FVNGIRTVLAKYK 541  starlet sea anemone
EKC40435     326 FVNGIRSVIYSHK 338  Pacific oyster
EEC17382     162 LYGAVKQVVDTHR 174  black-legged tick
XP_015783556 618 FMHKIQAAYKNAR 630  two-spotted spider mite
Q9VCB1       345 FVKRLREVLDEHR 357  fruit fly
Q9VCB1       176 FSERLQEILQGAK 188  fruit fly
EDV29329     416 FVQKFQVVMKKSR 428  Trichoplax adhaerens
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