Conserved Protein Domain Family
Med2

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pfam11214: Med2 
Mediator complex subunit 2
This family of mediator complex subunit 2 proteins is conserved in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with and phosphorylates Med2. Post-translational modifications of Mediator subunits are important for regulation of gene expression.
Statistics
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PSSM-Id: 402683
View PSSM: pfam11214
Aligned: 21 rows
Threshold Bit Score: 101.617
Threshold Setting Gi: 74603797
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGW33686       6 LQTKLDASLNDILKTSGYIF--EVLNNNKKQSNLLTGPNNQLitpqiIAQLSHQMLKFDDILDETITKFNDARWCIDQMV 83  Spathaspora pas...
XP_001645812  14 GKNKLVECFEDILEVSSQMLvqQQLKSIQLDNSVISGFNQGQ-----QKVLLEKVTLFHSILDDLEITLNKGKNYVDELT 88  Vanderwaltozyma...
XP_003683937  28 YRNKVTQCFDDILDVSTQMLvqQQLKTIQLDINVTNGFNLSQ-----QKILHEKVNLFHSLLDDLECTLETSKTFTEHIA 102 Tetrapisispora ...
XP_003668128  47 KTNKLTQCFDDILKLSTEMMvqQQLKTIQLDSNLINGFNENQ-----QNSLKEKINSFHGILDDLEISINKSLTYLDTIS 121 Naumovozyma dai...
CCC67574      14 PKNKLTQCFDDILKISSEMLlqQQLKTIQLDSKVSNGFNASQ-----QRSLKEKINLFHGILDDLEISIAKSFDYVDTIV 88  Naumovozyma cas...
CCK72512       3 EQNKLTRCFDDILRLSSEMLvqQQLKTIQLDT--VNGFTQDH-----QKVLSEKIHSFHGILDEVDVTLLNAVRFVEKFD 75  Kazachstania na...
Q757M0        21 RGDRLTQCLDDIMRASTEMMvqQQLKTIQLNSDVAAGFRKAL-----SKSLGDRVRAFHSILDGVETTLTTASQYLDAVE 95  Eremothecium go...
XP_003646867  12 NTDRLTQCLDDIMRAATEMMvqQQLKTIQLNSDVAAGFRKNF-----SKSLGDKVRLFHSILDGVDTTLTTASQYLETVD 86  Eremothecium cy...
XP_003681203  22 hRNRLTECFDDIMKVAAEMMvqQQLKTVQLDSAVVNGFSQAQ-----QRVLSEKIHMFHAILDDLQTTLTKSKSYVGTIH 96  Torulaspora del...
XP_002494556  20 HENKLTQCFDDIMRVAVEMMlhQQLKTVQLDSSVVNGFSHNQ-----QRMLSEKIHIFHAILDDMETTLGKSKDYVEAIY 94  Zygosaccharomyc...
EGW33686      84 ENKQRQEEMKIRE----EQERARRlkEEEE 109 Spathaspora passalidarum NRRL Y-27907
XP_001645812  89 KIGKDKEEERERVrraeEEKKRLL--EEEE 116 Vanderwaltozyma polyspora DSM 70294
XP_003683937 103 KLGKQREEEKL------KKDKERE--EELE 124 Tetrapisispora phaffii CBS 4417
XP_003668128 122 KISIEKRKENIKTkilkEQEEKEK--EKQl 149 Naumovozyma dairenensis CBS 421
CCC67574      89 EISNEKli--------kKKELQRK--EEEA 108 Naumovozyma castellii CBS 4309
CCK72512      76 AVSKEKELERVKQr---EREAQIT--AEEE 100 Kazachstania naganishii CBS 8797
Q757M0        96 EAAVKMKQWKQQQ----EEEQRRK--HQAE 119 Eremothecium gossypii ATCC 10895
XP_003646867  87 DVAHRMKQWKLRQ----EEELRRK--QQEE 110 Eremothecium cymbalariae DBVPG#7215
XP_003681203  97 EIALEKQKVKEKEr---ADLRKRQ--EEEE 121 Torulaspora delbrueckii
XP_002494556  95 ELGREKELQKEREr---EELRRRQ--EEEE 119 Zygosaccharomyces rouxii
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