4UF3


Conserved Protein Domain Family
M11L

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pfam11099: M11L 
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Apoptosis regulator M11L like
Apoptosis regulators function to modulate the apoptotic cascades and thereby favour productive viral replication. M11L inhibits mitochondrial-dependant apoptosis by mimicking and competing with host proteins for the binding and blocking of Bak and Bax, two executioner proteins.
Statistics
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PSSM-Id: 402602
View PSSM: pfam11099
Aligned: 6 rows
Threshold Bit Score: 128.753
Threshold Setting Gi: 75556522
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4UF3_A  25 KK--------------------LLNIYINDICTTGEKRLLNNYEKSILDRIYKSCEYIKKNYELDFNSMYNQININDITT 84  Mule deerpox virus
Q07036  72 YRfnkstnildylsterdhvmmAVQYYMSKQRLDDLYRQLPTKTRSYIDIINTYCDKVNNDYNRDMNIMYDMASTESFTV 151 Variola virus
Q6TUZ5  12 KD--------------------VIVFYINEKALIGRKKSLSNYENKLLNLIKKNCESILLNYKYNLINICDTLKVNDYTE 71  Yaba monkey tumor virus
Q77G99  12 RN--------------------VLYVYLKYNTI----NKLSRYERMIYTKIKNQCEAIKYRYCNDFNSVTCILEYDENKY 67  Swinepox virus
Q77PA8   6 KT--------------------AVYDYLNDVDI------TECTEMDLLCQLSNCCDFINETYAKNYDTLYDIME-RDILS 58  Myxoma virus (strain ...
Q9Q959   5 KE--------------------VVYTYLNGGDI------TECTEIDLLCQLVNCCNFINNTYAKNYDVLCDIME-RDILS 57  Rabbit fibroma virus
4UF3_A  85 SD---IKSKIIEALLIDSRPSVKLATLSFISLI----------AEKWGEKNRAKIMEILSNEIVEkISNNGKDFIDFIDR 151 Mule deerpox virus
Q07036 152 YD---INNEVNTILMDNKGLGVRLATISFITELgkrcmnpvetIKMFTLLSHTICDDCFIDYITD-ISPPDNTIPNISTR 227 Variola virus
Q6TUZ5  72 ENierIKSQIIESLNNDNRPSVKLAIVSLVSMI----------AELHGYKNQNILMSALIDDIASkISENSEDLIRFVKR 141 Yaba monkey tumor virus
Q77G99  68 IDn--VHKEVISILLSDSRPSIKLAAISLLSII----------IDKL-ICRNIRIAKYIIDDIINiISEDGIYIILFLDE 134 Swinepox virus
Q77PA8  59 YNivnIKNTLTFALR-DASPSVKLATLTLLASV----------IKKLNKIQHT--DAAMFSEVIDgIVAEEQQVIGFIQK 125 Myxoma virus (strain ...
Q9Q959  58 YNienIKKALGFALL-DASPSVKLATLALLSII----------LKKLNKIRHT--EACVFSDVIDgITAEENKVIGFIQE 124 Rabbit fibroma virus
4UF3_A 152 D 152 Mule deerpox virus
Q07036 228 E 228 Variola virus
Q6TUZ5 142 D 142 Yaba monkey tumor virus
Q77G99 135 F 135 Swinepox virus
Q77PA8 126 K 126 Myxoma virus (strain Lausanne)
Q9Q959 125 K 125 Rabbit fibroma virus
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