3JX8,3LYC


Conserved Protein Domain Family
DUF2807

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pfam10988: DUF2807 
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Putative auto-transporter adhesin, head GIN domain
This bacterial family of proteins shows structural similarity to other pectin lyase families. Although structures from this family align with acetyl-transferases, there is no conservation of catalytic residues found. It is likely that the function is one of cell-adhesion. In Structure 3jx8, it is interesting to note that the sequence of contains several well defined sequence repeats, centred around GSG motifs defining the tight beta turn between the two sheets of the super-helix; there are 8 such repeats in the C-terminal half of the protein, which could be grouped into 4 repeats of two. It seems likely that this family belongs to the superfamily of trimeric auto-transporter adhesins (TAAs), which are important virulence factors in Gram-negative pathogens. In the case of Parabacteroides distasonis, which is a component of the normal distal human gut microbiota, TAA-like complexes probably modulate adherence to the host (information derived from TOPSAN).
Statistics
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PSSM-Id: 402531
View PSSM: pfam10988
Aligned: 45 rows
Threshold Bit Score: 99.6224
Threshold Setting Gi: 152030773
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3JX8_A            22 DYDEITFVGSADFEYEQS-DKApYLSVTIDENLFDYLVTEV--E---GGTLKIYPKsi---kKGFNNNS----Ydlrptv 88  Parabactero...
EAR16606          22 PFREIKVFDGISLNLIRS-DRN-QAVVRGENT--RQVAVVN--N---DGILKVRMEi----tKIFSGYR----T------ 78  Robiginital...
EAR14366          21 NFHEIKVFDLIEVNMIRS-DEN-RIVIKGDRA--GDIEFVN--R---DGVLKLRMEf----dKKFRGED----T------ 77  Robiginital...
WP_013304623      28 DFNKIKVFDLIEVNLIKS-DEN-RITIKGDNV--FDIKVVN--D---NGTLKLRMQl----dKRFRGED----T------ 84  Maribacter ...
WP_013304629      40 TFAKITVFENVSLILEQG-DVQ-KVEIETGEFLLNEVTAYV--E---GDRLILQNEngcnffRDYGLTK----------- 101 Maribacter ...
EAR14377          45 GFSEITVFENVRLVVRQG-PEQ-RVVLETGKNLRDGVSARV--E---DGVLELRDSnncnlfREYGLTT----------- 106 Robiginital...
WP_013186965      48 GFNKIRIEEGVQLLLRQG-QSQ-QVILETGANLRSDVEVFL--D---NETLVARDNngcnlfRDYGVTK----------- 109 Croceibacte...
jgi:Anae109_4363  82 AFEGLRVEDGIHAEVTAGaESQ-RVVVSGDENLLQHVQTSVraDpvhGQVLEVRSSl-----SSFESTHp---L------ 146 Anaeromyxob...
Q1DGB8            55 DFDEVSVSHGIRAEVKVG-PK--SVRLEGPAELVSRIEMDV--H---DGTLRTRVD------KKLFSGFkggsV------ 114 Myxococcus ...
Q09D26            30 DFQGVSVSSGIKARVSVG-PK--SVRISGDEDAVARVRTTV--D---DGNLVVTMA------KGRGGGV----------- 84  Stigmatella...
3JX8_A            89 yKIKSNSKE-LKELNTvgsgsfiiskptkvnrxeinxagsgnvelrgpvkgyklecnxAGSGNIIAKdIQLDNLSCSLAS 167 Parabactero...
EAR16606          79 -FVDLYYTDpLLIIDVnedariesrdv---------------------irqdvlevkaQEGGEIVLE-AEVTQFLVKAVT 135 Robiginital...
EAR14366          78 -LIEVYYTD-ILVVDAnegaritcnem---------------------ieqdrielraQEGARIEVG-MKVRDAEIRAVT 133 Robiginital...
WP_013304623      85 -FIEVFYKH-LDVIDGnegakivcnel---------------------ikqdhleirsQEGAQIKAG-LDVVDLEVRAVT 140 Maribacter ...
WP_013304629     102 --VYVTSPN-ITEIRSstglpiksngvlgys------------sirlysesfvnpdaeTTDGEFDLE-LNSKNVGVVANG 165 Maribacter ...
EAR14377         107 --FYVTAPD-LGTIRSstgwpiasdgvlafd------------altlisesfnnpeteTTDGAFDMD-LAAGEVRLVANG 170 Robiginital...
WP_013186965     110 --LIVTSPN-IEDIINgssyeirsegtlnyp-------------tlrlrslvipgfdlRKNGDFHLT-LNAQDVSIVANG 172 Croceibacte...
jgi:Anae109_4363 147 -RVVVSVPV-FRFIAAtdgch------------------------------------------avvagVATDVMAVEADD 182 Anaeromyxob...
Q1DGB8           115 -RLYVSSPR-VEGIHAsggshvdada----------------------trtdefdveaSGGAIVNVRgVDARQVEAEASG 170 Myxococcus ...
Q09D26            85 -LLTLSSPS-VTHLEAssgasveahl----------------------aatptftieaSGGGEVSVDgLDSAKVEVEASG 140 Stigmatella...
3JX8_A           168 SGEIEVIGTVDRASF-NVA----GSGEIKAFDCQ-ARKAECNIASSGEISVYATQILDANIVGSGEIHYKGDP 234 Parabacteroides di...
EAR16606         136 GGIITASGKSKNQDV-QIN----TGGIYQGRDFA-TGFCTVNVNAGSTAEIHASDYVKATVKAGGKVFVYGDP 202 Robiginitalea bifo...
EAR14366         134 GGMVYASGLATNQVI-TLN----TGGIFEGRDLE-TETSSIRVSAGGEAELFAREEVDIQIRAGGDVYVYGNP 200 Robiginitalea bifo...
WP_013304623     141 GGIVEASGLAENQWV-VLN----TGGVFEGRELK-TSNTDIKITAAGEAEVFASEKVDINVKAGGDVYVYGNP 207 Maribacter sp. HTC...
WP_013304629     166 IAYFKLRGNTEHLSVtVAA----GDSRIEAEDLV-SETISLNHRGTNDIQVNPQQSITGVIRGTGDVISFNQP 233 Maribacter sp. HTC...
EAR14377         171 IAYFKLRGTAGSLRVtIAA----GDSRVEASELV-SGRVTLDHRGSNQVLVNPTGRLDGVIRGYGDVLSYNRP 238 Robiginitalea bifo...
WP_013186965     173 SSVFYLNGTTSNLNVsFSD----ELPRLEARDLI-AQNVSIRHVSSNHMYINPQESLTAELRGSGNVYSYNSP 240 Croceibacter atlan...
jgi:Anae109_4363 183 GADLVLSGAGGDQLTlRLAggkgGGAFLDARGYP-AGVATVELAGGARAELRVEDRVGGIVSGPSSLENVGGG 254 Anaeromyxobacter s...
Q1DGB8           171 GSKVTLAGRATDFDV-EAS----GGSIVRALDVKgVKTLDAEASGGSRVEVDASDRVSGEASGGSVLQLVSRP 238 Myxococcus xanthus...
Q09D26           141 GAEVTLKGRADVLQV-EAS----GGSEVHGQALR-LKALEAEASGGTRVKANPTDRVEAEASGGSSIHVETQP 207 Stigmatella aurant...
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