2PFC,5WSY


Conserved Protein Domain Family
FcoT

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pfam10862: FcoT 
Click on image for an interactive view with Cn3D
FcoT-like thioesterase domain
Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.
Statistics
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PSSM-Id: 402464
View PSSM: pfam10862
Aligned: 12 rows
Threshold Bit Score: 229.115
Threshold Setting Gi: 262082522
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2PFC_A               28 RVLEPYScKGCRYLIDAQYSaTed------------svLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVL 95  Mycobact...
AMEG_HIPS:KALB_7699   7 RVLLPYK-QDCSYLRSAEIT-Vesg-----------laTGRGRFEIPQSCYIEDTGHFNSVEFNICYNQLVYYVMASAVR 73  Kutzneri...
WP_005113189         29 RVLEPYSyKGCRYLNDAEYGiTsd------------avHAQGNFAIDESAYIRSTGHFNAVELVLCFNQLAYCAFAQGVV 96  Mycobact...
WP_023543236         22 RVLTPYRaKQCEYLTSATVTsEgdprd-------ggrlIATCTFEIPESCYIDDTGHFNSVEFNICFNQMAYYLLAMSVR 94  Streptom...
Q9CBG3               28 sILEPYSyKGCRYLIDAQYRaSpd------------svFAYGNFGIEESAYIRGTGHFNAVELMLCFNQLGYSAYAQSVV 95  Mycobact...
WP_014173120         26 RVLRPYR-TNCRYLGPAEVRlEne------------avTASGTFRIGESCYIDDTGHFNAVEFNICFNQIAYYLIAKCAQ 92  Streptom...
UANL:O3I_034370      15 RVLHCYK-PHCRYLRTLEVRsSge------------kvTATGTFEIPESCYIDATGHLNSVEVNICYNQMLYQTIAVMVR 81  Nocardia...
5WSY_B               16 RVLVPYK-DHCKYLRSAVVTeSdtg-----------raVARCEFAIPESCYIDDTGHLNSVEVNICYNQMMYYLVAKSVK 83  Streptom...
jgi:Hneap_0956       22 RVLSVYF-DNTRYLKSANIFlDdnga--------ksriVSHGKFSVPESCYIESTGHFNSVEFNICYNQIMYDAIAHATK 92  Halothio...
jgi:Hoch_6016        29 hILTPYM-TPCKYLKSVDISyDpsasng----vlpaklRARGRFSIGESCYIEDTGHFNAVEFIMCFNQIGYVLLAHALQ 103 Haliangi...
jgi:Cylst_3962       20 mfLEPYK-ENCKYLKKAQVQySnvgipkksqkvdeaewIIKGEFSIPDSCYIADTGHFNAVEFNICYNQLCYILMAYLVD 98  Cylindro...
Q096B9               21 QVLIPYK-PHCRYLLRAHLEhEgastpeg--rsrgngaAAQGEFSIPESCYIDDTGHFNAVEFNICYNQLAYFLLASCAH 97  Stigmate...
2PFC_A               96 NEEIRVLRGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIErt---wrYLKVPCVIEFWDENGGAAS 172 Mycobact...
AMEG_HIPS:KALB_7699  74 DRLMPAFTSWTLQDYWDRQLPNILITSLSSKFKRPIDPRSFSGEVGFTRITQRS-------LLIAETACRFWDDNGGQAS 146 Kutzneri...
WP_005113189         97 NDDIWAFRGWSIDDYCENQLASMLIKSTSSRFRRLVNPRQFSARLQARDFHIVDrs---wrYLQFHSTIEFWDQDGGSAA 173 Mycobact...
WP_023543236         95 ESLVEPFSGWTIEQFWTRQLADVFITDFKSSFRSAMQGRRFTGEIEIIDIAEWDandlrdaLVILRTKCHYADEQGGESH 174 Streptom...
Q9CBG3               96 NKDISALRGWSIADYCRNQLSGILIKNTSSRFKKLINPQKFSARLHVYDLRIVErt---wrYLQLSNTIEFWDDNGGSAI 172 Mycobact...
WP_014173120         93 NRLPPVFAAWTLDDYWQRQLSDILITRFTSRFHRAIRGQEFRGELSFTDFKLRSgengrapLALIESECRFWDKGGGRCT 172 Streptom...
UANL:O3I_034370      82 GQL-GVFAEWTMDDFWRRQLPDILITRFHSDFRRPIDPRRFSGEFTLDDSRERTssldgtpFTALDTSFRCWDDHGGHCA 160 Nocardia...
5WSY_B               84 EGLLAGFESWTLDDFWKHQLPDILIARFASNFRRPVNPRAFSGEMEFQSVTRRApag-gipFLHAETAYRYWDADSGRCD 162 Streptom...
jgi:Hneap_0956       93 YELVPQFCAWGTEGFFSRQLPDILITSFNSRFTKPVNSVDFSGEFTIHTMRLHNkg---qpFLFIKTGCRFFDDEQGEAV 169 Halothio...
jgi:Hoch_6016       104 AGLVRGVPAWGREDFAERQLPDVLIVNAKSTFRRMIDARDFVGEAVWTRASARGd------HLFGSFDVSFYDAAGGRST 177 Haliangi...
jgi:Cylst_3962       99 NKLLDAMKHWDLKTYKERQLSNCLIAKFSSTFKKQINARQFQGLLAINKSSFRGn------LIILKTSCVFYDEYEGWAE 172 Cylindro...
Q096B9               98 HRL-EPLAAWSIEEYRRRQLSDFLIVQFSSSFRKQMKAAHFTGRVELRKVMGRGk------SLFIKTYCRFEDGHGGLSE 170 Stigmate...
2PFC_A              173 GEIELA 178 Mycobacterium tuberculosis
AMEG_HIPS:KALB_7699 147 GEITLA 152 Kutzneria albida DSM 43870
WP_005113189        174 GEFDIA 179 Mycobacteroides abscessus
WP_023543236        175 GEITAA 180 Streptomyces niveus
Q9CBG3              173 GEFEVA 178 Mycobacterium leprae
WP_014173120        173 GEIQIA 178 Streptomyces
UANL:O3I_034370     161 GVVRLA 166 Nocardia brasiliensis ATCC 700358
5WSY_B              163 GEAVLA 168 Streptomyces avermitilis MA-4680 = NBRC 14893
jgi:Hneap_0956      170 GEVDLA 175 Halothiobacillus neapolitanus c2
jgi:Hoch_6016       178 GE---T 180 Haliangium ochraceum DSM 14365
jgi:Cylst_3962      173 GDVTIA 178 Cylindrospermum stagnale PCC 7417
Q096B9              171 GEPLIA 176 Stigmatella aurantiaca DW4/3-1
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