Conserved Protein Domain Family
DehI

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pfam10778: DehI 
Halocarboxylic acid dehydrogenase DehI
Haloacid dehalogenases catalyze the removal of halides from organic haloacids. DehI can process both L- and D-substrates. A crucial aspartate residue is predicted to activate a water molecule for nucleophilic attack of the substrate chiral centre resulting in an inversion of the configuration of either L- or D-substrates in contrast to D-only enzymes.
Statistics
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PSSM-Id: 402418
Aligned: 6 rows
Threshold Bit Score: 164.995
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Npun_F0199         397 PWTPANWR-AYAMYPSVMQLFWQRLKPAMQTEAFLEDAIAISEHVYRDINDWYQPGYQI-------EVEQAQQHHIRQEL 468
WP_011521593            30 PYVPTIFK-AAAGNSTYIREMWDDLYEVACSKEFHASAETLNQFINAQVIGTRWRFSNQerlltaqKFSPADVRVMAGVA 108 Candi...
jgi:Acid345_2343        35 GYVPVPFQ-AFAAYPAFLDALIKAMRPLLATREFFDSAARLRAEAYTDVHNYFKVAAIG-------EGLSAAEAAAEMEL 106
PRJNA212797:N288_14555  80 PIINFIFR-ALAQYEKFLYTGWQQVRSSMLTMSAERAAASLREPSLSFVPERYDWASIM---------GMERLKKVEKIV 149
WP_015408529            30 PIVNWIFRtTMANHPEFVRCMWGQLKPAFETRQFGRVSVAYRDSVLSPLERERDLPAYRra---dvGVSPAEYAELRAQL 106 Natro...
jgi:Htur_4368           30 PIVNWIFRtTTANYPEFLRYAWGQVKPAFETARFGRFSVSYRDTILSALEAETSIPTYRrd---elEVTPAEYGELRGQL 106
jgi:Npun_F0199         469 NAFIFGNPQLL--IQQIALSKTLAGEIVGQ-DGSIDSRHGPnayrhhQIQLIDEQSAQEISPEMPQVYQDIKQTLGVPIV 545
WP_011521593           109 STFQRALPRMA--LFTRLMQRGYSGGQRGRvSARHGSSPFA------RMITLHIPSESEASLRTWLIYSEIKRNTASKQV 180 Candi...
jgi:Acid345_2343       107 FGFVESAMLLMlsVQSQAFEGPVGLDVAGHpAGLMAIMSSP-----------DFVNSETTSPPVKRVLDEQRHLLELAYY 175
PRJNA212797:N288_14555 150 FTFNYVNPKLL--LIALAWQESLGYRPIKGvALSGGLIEPGillglpSIRLIDFPEADSRQKELLWDIMTVKHSYD---I 224
WP_015408529           107 STFDVVAPRLA--VLFEVVERSLSGEPVGT----------------------TPERSRAATEPLPPELDRDRGGPPTLAT 162 Natro...
jgi:Htur_4368          107 ATYDIVAPRLA--VLFELVDRALTDEPIGT----------------------DPDRSRAATAPLPDWLDADRGRPPTMVA 162
jgi:Npun_F0199         546 NSDY 549
WP_011521593           181 PSMF 184 Candidatus Koribacter versatilis
jgi:Acid345_2343       176 SDEQ 179
PRJNA212797:N288_14555 225 ASDY 228
WP_015408529           163 VEDP 166 Natronomonas moolapensis
jgi:Htur_4368          163 FDEP 166
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