Conserved Protein Domain Family
YrbL-PhoP_reg
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pfam10707: YrbL-PhoP_reg 
PhoP regulatory network protein YrbL
This is a family of proteins that are activated by PhoP. PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multicomponent loop in Salmonella where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner.
Links
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Statistics
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PSSM-Id: 402374
Aligned: 9 rows
Threshold Bit Score: 233.36
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2KYP8           24 IDLNDASLLAHGGDRYVFEHPNDSCLLIKVMDMQArgvylasrpfkrwykqfqRESAYRVYLNEFNEYVTSTT-RPSGIW 102 Bordetella a...
Q16BG7            8 IKLSDDHSIANGTVRIVYAFPGQPDLLIKVFHAFEerssrrpl--krlawrlfPMLKFRTILNELKCELLASLkLGADIE 85  Roseobacter ...
wugsc:CKO_02085   4 LTLTENDLLARGNDRYVFQHPHNHQLLIKVVIPSI--------------------PKYKSKLREVYRDVKECK-PRDETD 62 
Q7VT79           49 VDLLGATLLATGSERDVYQHPGNAALLIKIVNRARinepgrrr---pwhkkfhREDAHRVFITELIEYISTTVqLRQADG 125 Bordetella p...
Q7VWB8           13 LDLSQARLLAQGGDRYVFQHPHEPALLVKVMDMEAravylearpfkrwykqfqRESAYRVYLNEITEYVTTST-SASGVW 91  Bordetella p...
wugsc:CKO_04610   2 ILLSEQNPLGTGRHRKCYAHPGDAQRCIKIIYNAD-------------------RSGKKEIRRELKYYAHLS---RYLQD 59 
Q7CPN6            2 ILLSKQTPLGAGRHRKCYTHPDNARRCIKVIYNRD-------------------HGGDKEIRRELSYYAHLS---RYLTD 59  Salmonella e...
USDA:Abu_1812     2 IELREELLLGDGGERLVFIHPNDSKKVIKVLQPQI-------------------KKHNFQNELEFKYYNFLT---KKNVD 59 
USDA:Abu_1805     2 IILKDEDFVGKGNERACYIHPEDKNKAIKITYENN------------------NRKESKQTKLEVNYYKELEK--RRMIN 61 

Q2KYP8          103 QVPLARVMGVAQTNLGLGLLVEKIRDKNGNMAPSLKDLI---KQGLYTQ-DIARQMDQLFEDLADAHVVAH-DISAGNVV 177 Bordetella a...
Q16BG7           86 NMPISRMLGIVQTDRGVGVVVERIDGLDGDLAQRLNRLC---RRGRMDE-PVLEALNVFVGRMFDLHIVAR-DINFSNIV 160 Roseobacter ...
wugsc:CKO_02085  63 SLFIQKIEGLVETDKGIGQVIVKEHDQQGNIARTLYDLA---KHNELDA-EKFSKLNAFLAWFIHTDVIIN-SLHCKNIV 137
Q7VT79          126 NTLLARIAGLALTSAGLGLVVEKIVDAEGKAAPTLAQVV---STQGFGP-QLREQLRAFFLALIEAHVIFN-DVSARNIV 200 Bordetella p...
Q7VWB8           92 QVPLARIVGLAQTSLGLGLLAEKITDAAGNMAPTVSDLV---KRGEFDT-ALAQRLDRFFEDLADAHIVIH-DISASNIA 166 Bordetella p...
wugsc:CKO_04610  60 WSGIPRYHGTVETDCGTGYVYDVITDFDGKPSVTLTEFVaqcRNDEDAA-VLRQLLKTLKRYIYDNRIVTM-TLKPQNIL 137
Q7CPN6           60 WSAIPRYYGTVETDCGTGYVYDMITDFNGAPSITLTEFAaqcRYEEDVA-VLRRLLKKLKRYLLDNHIVTM-SLKPQNIL 137 Salmonella e...
USDA:Abu_1812    60 FSHITKCFGYVDTNFGKGLVFERVVDFDGEDSKFLRNCL---QENIFTKdQEKRLLDDLKKYLEDNEILFI-DCSSHNVF 135
USDA:Abu_1805    62 FKHLPKYFGEVKTDKGAGFVVELIRDFDGEVSKTFEYYL---KKDGVLK--YKKELEEYKQYFLDNCIIFNyGMMPKNIL 136

Q2KYP8          178 MGYNAEGRh-GLFLVDGFGVQPL---IPAYAWSRRLNRRRLLKKYRNMRAKLP 226 Bordetella avium 197N
Q16BG7          161 YGTRGAGA--ACFLIDGYGERNL---IPFRSMSRRMNDRSLDRQFATIARKTG 208 Roseobacter denitrificans OCh 114
wugsc:CKO_02085 138 YAWDDARQeyRFKVIDGFGDKTL---FQLSKFWSVIRDKNKLKCLRRMLRDLQ 187
Q7VT79          201 VGRNATGQd-GLFLVDGFGPKQL---LPLYAWSKTLNRRRLLRKYEDMVRKLa 249 Bordetella pertussis
Q7VWB8          167 CGRNAEGRe-GLYLIDGFGVLPL---IPTYAWSRRLNRKRIMRKYAELRARMp 215 Bordetella pertussis
wugsc:CKO_04610 138 CHRISESEa-IPVICDNIGESTL---IPLASWSAWFCHRKQERQWERLIAQPG 186
Q7CPN6          138 CQRISESEv-VPVVCDNLGESTF---IPLATWSTWCCERKLERVWQRFIAQPa 186 Salmonella enterica subsp. enterica ser...
USDA:Abu_1812   136 CKKVSADKy-TLIIYDGLGARRDnikLTLYMKSRFYTRYKIKKQWKLFMKNCE 187
USDA:Abu_1805   137 LRKNSETDf-DLVLIDGLGDVSY---FTLPNKIPYFARKRINRRWDKFIKKYL 185
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