Conserved Protein Domain Family
EssA
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pfam10661: EssA 
WXG100 protein secretion system (Wss), protein EssA
The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (pfam06013) such as ESAT-6 and CFP-10 in Mycobacterium tuberculosis or EsxA and EsxB in Staphylococcus aureus. In S. aureus, the Wss seems to be encoded by a locus of eight CDS, called ess (eSAT-6 secretion system). This locus encodes, amongst several other proteins, EssA, a protein predicted to possess one transmembrane domain. Due to its predicted membrane location and its absolute requirement for WXG100 protein secretion, it has been speculated that EssA could form a secretion apparatus in conjunction with the polytopic membrane protein EsaA, YukC (pfam10140) and YukAB, which is a membrane-bound ATPase containing Ftsk/SpoIIIE domains (pfam01580) called EssC in S. aureus and Snm1/Snm2 in Mycobacterium tuberculosis. Proteins homologous to EssA, YukC, EsaA and YukD seem absent from mycobacteria.
Links
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Statistics
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PSSM-Id: 287614
Aligned: 4 rows
Threshold Bit Score: 141.179
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8YAQ8    21 LAADSDSYLENNGKMDIKTDRLQKTEEEKTKelEQMEETELDKNGIPLFTDEMDEKIAKEKAAEKAEYDRIKDSLFEEES 100 Listeria monocytogenes
Q813N6    25 IRSAADSYLGDDGKIKFKVDRLEESDQEKNK--KEHKETELDKASIELFNKDIEEEIEKKKKKEQKDMEALRDSLFIKQK 102 Bacillus cereus ATC...
EEM05738   1 mGSAADSYLNDNGKLDFKVDRLHEDNQERNE--KGQQETELDKAAIQLFNEEVEKQINEKQKKEKKEMKELNDSLFLNTK 78 
Q8ERI9    24 IGVSADTGSEKDGSMQMQIDRIIKDKDEKNE----LRETELERLFPSLFTTETSEEINEKVNAEEDKIEDIEQNLFSEDV 99  Oceanobacillus ihey...

Q8YAQ8   101 TSGeTVKKTKEKLFTGEYETTAVNTETpTTTETTVEDETKKTkqktVGGAIAGTLVALAGGIYVAARNVFE 171 Listeria monocytogenes
Q813N6   103 ENN-SVKDTKNSLFSSEYIVRKSADEV-ASNETMNEEPISIT----IILLFGGGILLICIGIYTVLRKSWR 167 Bacillus cereus ATCC 14579
EEM05738  79 KID-KMKDTQKSLFSKNYNVRASSSEM-DHSQAKTEESISPT----LIGLIIIGVIFIFIGFGIIIRKIWM 143
Q8ERI9   100 EGNvAIQEVKDSLFQSDYESVA------ASSGNAEEESTSSSssniILMTFAGIAVALCGGLYVLMQRLLd 164 Oceanobacillus iheyensis
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