Conserved Protein Domain Family
Misat_Tub_SegII

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pfam10644: Misat_Tub_SegII 
Misato Segment II tubulin-like domain
The misato protein contains three distinct, conserved domains, segments I, II and III. Segments I and III are common to Tubulins pfam00091, but segment II aligns with myosin heavy chain sequences from D. melanogaster (PIR C35815), rabbit (SP P04460), and human (PIR S12458). Segment II of misato is a major contributor to its greater length compared with the various tubulins. The most significant sequence similarities to this 54-amino acid region are from a motif found in the heavy chains of myosins from different organisms. A comparison of segment II with the vertebrate myosin heavy chains reveals that it is homologous to a myosin peptide in the hinge region linking the S2 and LMM domains. Segment II also contains heptad repeats which are characteristic of the myosin tail alpha-helical coiled-coils. This myosin-like homology may be due only to the fact that both myosin and Misato carry coiled-coils, which appear similar but are not necessarily homologous (Wood V, personal communication).
Statistics
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PSSM-Id: 402330
View PSSM: pfam10644
Aligned: 44 rows
Threshold Bit Score: 110.029
Threshold Setting Gi: 74590322
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001964060   5 REILSLQLGTYANYVGAHFWNQQEANF--CYGDGDGDdqv-aeEHLlHNDILYREGLN--S-HNRTTYTPRLVSVDLAGT 78  Drosophila anan...
Q10PA8         2 REAVTVQVGGFANYVGSHFWNFQDELLglADDPDADPvf--knDAL-DMDVLYRSGET--H-QGIPTYCPRLVSVGSRGS 75  Japanese rice
EEF40011       2 REIVTVQVGGFANFIGSHFWNFQDELLglATDPDSDPvfkhcaDYL-NMDVLYRNGET--Q-QGIHTYTPRLISINGQGS 77  castor bean
EGD73510       7 GEVITLQFGNYANHVGAHFWNLQDAMI--DYTGQEPEs----eDPI-SHDVLFRCGET--P-SGAPTYTPRLLLYDLRDS 76  Salpingoeca ros...
Q018N1         3 SSVVTASFGTHAASVAAHFWNVRED----DSDENDEVd-----WNV-DHAERARVNEG----STSISYVPRWVAFDARSL 68  Ostreococcus tauri
Q5A2W2         2 SEIITLSYGSICNNTVTHLYNTQESLI--SYTPSSKP----------NHDLQVFL--TrfK-STSVSYSPRALIYDLRNG 66  Candida albican...
EFI95584       2 REIVYIQSGNLANYVGSHFWNTQECYL--T--DEDE-------TPY-DRRMSFRESLAdsG-KGAICYSPRALIFDHKSN 68  Schizophyllum c...
XP_001886252   2 KEILYIQAGQLSNYTGTHFWNTQESYF--TYGDGEE-------PLT-NNDVSFREGIG--P-TGELTICPRLVIFDRKAN 68  Laccaria bicolo...
Q9P6K5         2 HEILTVTFGRKSNFCWTHFWNTQESYF--VYDPNDH-------AKV-NVNTNFRVLKK--RdPEAIVTVPRECIYDTPIE 69  Schizosaccharom...
XP_002173475   2 HEILSFAFGGKSNFVSTHFWNAQEKYL----DQGND-------AQI-DREVAFFERKTnnI-GGDVVFHPRTLIYDDRDA 68  Schizosaccharom...
XP_001964060  79 LAHLPLGGELYGnfvqrdeellpfgtgedlnktRQRVE-ESGVAPTS-----------QLELQE-EPPTQLSEYQRDLMK 145 Drosophila anan...
Q10PA8        76 LGSLSSSGNLGQ---------------------TSASAdQLNVATWSg----------SVTRSV-SKPHGRNLFLQSLVE 123 Japanese rice
EEF40011      78 LGSMSSHGTLYT---------------------DGSST-SSEVITWTg----------NISTHA-SGPSKKNLFLQSLSE 124 castor bean
EGD73510      77 TSALSQEGVLYG----------------------DASQ-QAQVASWDp----------ERVERLmQPLDEPSPYHQHLEQ 123 Salpingoeca ros...
Q018N1        69 RGKTTATGLSSG-----------------------DAA-AAAAAAWSg----------AWTVTR-APPTRRSAYARALER 113 Ostreococcus tauri
Q5A2W2        67 LGALNKYEYHETlp-----------------vdLNFSL-LSTNTTAPagaetgagsslESGYNLkKSRVEKNEYQQKLDQ 128 Candida albican...
EFI95584      69 FGTFAKSNILSSte-----------------ndQSPDT-AAVASLWKg----------AVDEQQ-SDPIPKSDYHAKLER 119 Schizophyllum c...
XP_001886252  69 FGTLAASNALGEvd-----------------dvEDESGsESAPGPWTg----------GIVEYR-QTRMAKSVYQNRMED 120 Laccaria bicolo...
Q9P6K5        70 FGNTRK-NWLEE---------------------LNESS-GGKGTAWDg----------KLTQIM-QTPVDVHPYQEALWS 115 Schizosaccharom...
XP_002173475  69 FGTTIKNSKLLQpdivennnnidifgyakndnrKTGEG-PEDVNTWSg----------KTVCVE-APPLPLHPYQAWLDQ 136 Schizosaccharom...
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