4NHL,6E0T


Conserved Protein Domain Family
Ofd1_CTDD

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pfam10637: Ofd1_CTDD 
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Oxoglutarate and iron-dependent oxygenase degradation C-term
Ofd1 is a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N in the presence of oxygen. The domain is conserved from yeasts to humans. Yeast Sre1 is the orthologue of mammalian sterol regulatory element binding protein (SREBP), and it responds to changes in oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and this Ofd1 C-terminal domain accelerates Sre1N degradation in yeasts.
Statistics
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PSSM-Id: 402326
View PSSM: pfam10637
Aligned: 28 rows
Threshold Bit Score: 201.766
Threshold Setting Gi: 74942745
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NHL_A           336 AEFTYLSQYISPEHLSSKGIEKLQKQFVENSSLQIESFLNDDKSELLKKVI--KQKELEQe--CPYHSKDVKA--P---- 405 Saccharomyc...
Q0UUD7           325 NEIDFLIKYMNPNYLTPDTVEEVSKTFSDDSSIRLADFLSVKFSTKLCEYLesKDHEKNPa--LPANPHHKESkvG---- 398 Parastagono...
XP_001597651     328 ADLDFLLKYMAPTYLTPDTLDQVAERFQEESNVTLDGLLSVKFAAKVREYVeaQEAAA-----LPESTEEIEKg------ 396 Sclerotinia...
Q2H5Y7           326 ADLEFLLKYIAPTYLVPDTVERIADHFEEEFSITLPDILHPKFAEKLRQYVesQEAKT-----TPQDSKEIEKg-A---- 395 Chaetomium ...
Q7SCL7           330 ADLEFLLKYLAPTYLTPDTIENIADQFEEQFSITLSDILHPKFAAKIKEYVeaQEAKK-----LPEGSEEIEKsgA---- 400 Neurospora ...
Q5AVX6           339 SDLNFLVQYIAPSYLTPDIAEEMSDAFLNDSSLNLEHFLSKKFAAKVRSYIeeQEKKE-----LPASSDEIQAstD---- 409 Aspergillus...
XP_011387788     285 DEKKFLLQFLNPAYLVAKTQEQLFEQFGDDSHILLSDILKKEIAQSLEKSLrqADAKDGFqwwTSGKGEESTRiqPhavg 364 Ustilago ma...
Q01F03           264 SLVQDLTKWINPEYLRSESVKRVRQVFEADGSVQLFNFLLPHIAEPIKRKLnrEDCRNSRhrcmyd-------------- 329 Ostreococcu...
jgi:OSTLU_119509 269 ELSSFLHKWVKPEYLIHENIIRIREHFQNEGSIQLHDFLLPSIADSLREKLkrEDSRNRRkcgqyd-------------- 334 Ostreococcu...
XP_001637143     269 LEDEHLVKWVNPIYLDQGVVTEIRGRFEDESEVELQDFLLDDKYTEVLEALrsEKTT----------------------- 325 starlet sea...
4NHL_A           406 -------------WKTAIPPHKARYLYIDGKEYRNFQTEAdilealnnndlpnfqftkdaikiisdasgnsrennfdaeL 472 Saccharomyc...
Q0UUD7           399 ---------------VARPPHKHRYLYRKAIQPIPTTPYPesd----------------------------------gmT 429 Parastagono...
XP_001597651     397 ------------sWKVAKPPHKHRFLYQQPSDSQGSDNKKe-------------------------------------mN 427 Sclerotinia...
Q2H5Y7           396 -------------WKVARPPHKHRYLYLQPGQKKLED------------------------------------------S 420 Chaetomium ...
Q7SCL7           401 -------------WKVARPPHKHRFLYLQPGEENAPD------------------------------------------S 425 Neurospora ...
Q5AVX6           410 -------------WTVARPPHKHRYLYQEPSAEAGHSK-----------------------------------------T 435 Aspergillus...
XP_011387788     365 tdrvddadneakqWSISGPPHKQRYA-VQSEQATPKKAGEiasqntlvp----------------------nplptdagA 421 Ustilago ma...
Q01F03           330 -------hgygdsWVVQGPPHVQRYLSYQPLECTLANKRSns------------------------------------gE 366 Ostreococcu...
jgi:OSTLU_119509 335 -------yacghgWSVKGPPHIRRYLSYQPDSARTNRNdv--------------------------------------gD 369 Ostreococcu...
XP_001637143     326 -------------WSHRGPANKRCYETADSLP-----------------------------------------------E 345 starlet sea...
4NHL_A           473 ALIDLA-VFHKSTIFKKYLALLTSL-CP----------------------------VSEQILIRRFRPGMDFTLATKCRf 522 Saccharomyc...
Q0UUD7           430 PYDDLVdVLFPHPAFTKWISLATGI-TL----------------------------TKSNIFARRFRRGLDYTLATAYEe 480 Parastagono...
XP_001597651     428 PIEEILnVFLPSTQFRKWLEIATSC-QI----------------------------ENYNLLARRFRKGSDYALAKNYEg 478 Sclerotinia...
Q2H5Y7           421 PLKELLeVLLPSKQFRLWLQMATRS-HI----------------------------ESHDLLARRFRHGKDYTLATGHEg 471 Chaetomium ...
Q7SCL7           426 PIKELLdVLLPSRQFRLWLQMATRS-TI----------------------------EGHDLLARRFRHGKDYTLATGHDg 476 Neurospora ...
Q5AVX6           436 PLQELLnDLFPSKPFRKWLSLITGSdRI----------------------------TSYNLLARRFRRGKDYTLANSYVg 487 Aspergillus...
XP_011387788     422 LLKLLStVLFPSIAFRHFLANISQLvPL----------------------------GARPIEARRFRPGLDYTLARSDTe 473 Ustilago ma...
Q01F03           367 LLKKLMcDLFESSSFQNWVRAVTGS-VC----------------------------DLAHSEVRRFRPGFDYTLAHAGTk 417 Ostreococcu...
jgi:OSTLU_119509 370 RLEEVLiNVTSTVGFQNWLSAVTGF-HC----------------------------THAFSEIRRFRAGLDYTLAHSDIf 420 Ostreococcu...
XP_001637143     346 VLCELQ-KLLKSLPMFKLLRTFTGLdLAdtpltsnegsptqaaqdgtgagtsspgnPRCHGEARRWSHG-SYTLVHDTDp 423 starlet sea...
4NHL_A           523 NEllksnpdiidAVLEGTLCLTP-------------------------------------------------SAGWESG- 552 Saccharomyc...
Q0UUD7           481 ED----------PQLEVCLGITP-------------------------------------------------SKGWGDEd 501 Parastagono...
XP_001597651     479 N-----------PRLEVDLGLTP-------------------------------------------------TTGWGDDg 498 Sclerotinia...
Q2H5Y7           472 K-----------PRLEVNIGLTP-------------------------------------------------TEGWGDIe 491 Chaetomium ...
Q7SCL7           477 K-----------ARLELNIGLTP-------------------------------------------------TDGWGDVe 496 Neurospora ...
Q5AVX6           488 EE----------PRLEFTLCLTP-------------------------------------------------TPGWEKEd 508 Aspergillus...
XP_011387788     474 ------------PVLDVTLNLTPdvvkpsleeerkagprglaskakkgkvapvkpssftgskmlskkeakdlAAKWESG- 540 Ustilago ma...
Q01F03           418 RCs---------SEIDVTLCLTSgp----------------------------------------------nPAEWLSG- 441 Ostreococcu...
jgi:OSTLU_119509 421 KD----------SQIDVDLCFTSg------------------------------------------------PSQWLSG- 441 Ostreococcu...
XP_001637143     424 ERa--------eFALDIMLYCGC--------------------------------------------------EDWDSD- 444 starlet sea...
4NHL_A           553 ---------------------------------------------------------ELGGYELYM---MDDDEDNkqyl 572 Saccharomyc...
Q0UUD7           502 eepeeekpqkngnssksk--------------------gkgkangkapaqpepkpeeEVGGYEMYM---AGEDDEDhpti 558 Parastagono...
XP_001597651     499 nddeenednesdhdeeeeeeeakq--------kskskekekskgekkasepeqeeedDVGGHLVFM---AGDDEND---- 563 Sclerotinia...
Q2H5Y7           492 dddasseassepeeshsskngkktaangksnandkakgkgkgkavdqdvdmdddkeeEVGGHEVYM---AGDDDDN---- 564 Chaetomium ...
Q7SCL7           497 eeeedeeeeeeseeeeakgkgkgkg------katsngsskgkgkavektekaeeetvEVGGHEVYM---AGDDDDD---- 563 Neurospora ...
Q5AVX6           509 peeeeeasgdangtseass------------------skkasnkksesksdqddheiSVGGYEIYM---AGDDEEEks-- 565 Aspergillus...
XP_011387788     541 ---------------------------------------------------------DIGGWECYM---APHEGEE---- 556 Ustilago ma...
Q01F03           442 ---------------------------------------------------------DLGGFKCFIpigSKSDRAD---- 460 Ostreococcu...
jgi:OSTLU_119509 442 ---------------------------------------------------------DLGGYQCFTsteATDGAAD---- 460 Ostreococcu...
XP_001637143     445 ---------------------------------------------------------KFGGYTSYL---VSGEDEE---- 460 starlet sea...
4NHL_A           573 --------------kedvEDASVYRA-----------------------------------------DDSGDSVLINDPP 597 Saccharomyc...
Q0UUD7           559 ptshnatetgagqrrkakADPAIYKSa---------------------------------------aDDEDDGILFSQPA 599 Parastagono...
XP_001597651     564 ------------------EDAAIYKAa---------------------------------------gEEEDDGVLFTMPA 586 Sclerotinia...
Q2H5Y7           565 ------------------EDAAIYKS-----------------------------------------SADDDNILFFQAA 585 Chaetomium ...
Q7SCL7           564 ------------------EDAAIYKS-----------------------------------------SEDDDNILFFQAA 584 Neurospora ...
Q5AVX6           566 ----------------gaADPAIYQSa---------------------------------------aDDEDDGILFSTAA 590 Aspergillus...
XP_011387788     557 -------------------DPAVYQSgnsgkkkandeeneadavmkdaeddegeeivemieddgdeaDDDFDGVLLNLTP 617 Ustilago ma...
Q01F03           461 ----------------------VYE------------------------------------------EIGEEQNMRSVTP 476 Ostreococcu...
jgi:OSTLU_119509 461 ----------------------VYSG-----------------------------------------DIAENESLRSIAP 477 Ostreococcu...
XP_001637143     461 --------------------------------------------------------------------------LLSVSP 466 starlet sea...
4NHL_A           598 AWNTFNLVLRDESVLEFVKYVSWSA-------KSSRWDVKMKWDV-KSCDED 641 Saccharomyces cerevisiae S288C
Q0UUD7           600 AWNNLAINLRDKGVLRFTKYVSKSA-------KGDRWDVCAEYGV-EFGDDE 643 Parastagonospora nodorum SN15
XP_001597651     587 SWNKMSIVLRDSGVLKFVKYVSKNA-------KGDRWDISGAFGVqEEEDSE 631 Sclerotinia sclerotiorum 1980 UF-70
Q2H5Y7           586 AWNKMSIVLRDSGTLRFVKYVSASA-------KGDRWDVSGMFEI-EEQDED 629 Chaetomium globosum CBS 148.51
Q7SCL7           585 AWNKMTLVLRDSGTLRFVKYVSRAA-------KGDRWDVSGSYEI-EEQDED 628 Neurospora crassa
Q5AVX6           591 GWNRLSIVLRDSGTLRFVKYVSAAA-------KGDRWDITGEMGV-EFNEDD 634 Aspergillus nidulans
XP_011387788     618 SFNTLSVVLRDEGVMRFVKYLAASA-------GGSRWDVIGEYEIgAIEMEE 662 Ustilago maydis 521
Q01F03           477 SFNCLSLVKVNTGIGDFVKYVSTSA-------KSSRWDIVCRYST------- 514 Ostreococcus tauri
jgi:OSTLU_119509 478 TFNSLTLVKVDKGITNFVKFISTHA-------KGSRWDITSRFVVaKST--- 519 Ostreococcus lucimarinus CCE9901
XP_001637143     467 FANSLALVYRDMETLKFVKHVNHKSvkgasssSQSFYDFHMVYYE------- 511 starlet sea anemone
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