Conserved Protein Domain Family
MAGUK_N_PEST

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pfam10608: MAGUK_N_PEST 
Polyubiquitination (PEST) N-terminal domain of MAGUK
The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination. PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerization of the whole protein.
Statistics
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PSSM-Id: 402306
View PSSM: pfam10608
Aligned: 20 rows
Threshold Bit Score: 84.0489
Threshold Setting Gi: 2497508
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023821275 128 KKYRHH---DED-SSPQEQSSPPLTEEAGG----PElVQVAEKNLSEIENV------HGYVTHAHispmkaaslecifdd 193  Japanese medaka
Q62936        52 GGYSSQtlpSQAgATPTPRTKAKLIPTGRDvgpvPP-KPVPGKNTPKLNGSgpswwpECTCTNRD--------------- 115  Norway rat
8_pfamImport   1 --YNSQ---TLQsSGSTLARSRGKLSTMRSes----iwKSPSKSVAKGKGAnsewwsDCSCPHGWhds------------ 59  
Q6ZSU2        44 lGYSSQ---TMPsSGPGGPASNRTGGSSFNrtlwDSvRKSPHKTSTKGKGTcg---eHCTCPHGWfsp------------ 105  human
XP_005997201  95 eKHKCQ---DED-SLISDIRLPKYAESAQSfsqdPElVTVTSRSTELKESI------YSVVSHSHial------------ 152  coelacanth
XP_011481761  34 KKYRYQ---DEE-TPPLEHSPAHLAQGKSA-----EmLHMSDKNLAAMEAI------HGYTPHTHispvkpvlms----- 93   Japanese medaka
1_pfamImport   1 QKYRYQ---DEE-TPPLEHSPAHLAPGKSA-----EmLHMSDKNLAAMEAI------HGYTPHTHispvkvgrvlvdpqt 65  
BAE89987      14 kKYRYQ---DED--APHDHSLPRLTHEVRG----PElVHVSEKNLSQIENV------HGYVLQSHisp------------ 66   crab-eating ma...
XP_020778562  34 kKYRYQ---DEE-TPPLEHSPAHLAPGKSA-----EmLHMSDKNLAAMEAI------HGYTPHTHispvkpvl------- 91   great blue-spo...
OCT65730      43 GGYNSQtlpSQPaVTPTARGKSKLMPATREnl-tPTlKAPPKSATPKMNGNsqnwwpECTCTNRD--------------- 106  African clawed...
XP_023821275 194 sstlgplqselpsptlstlylhgedsplpscssnpyPPIQANPPPVVVNTDSLDTPPYVNGAEAEYEYE 262  Japanese medaka
Q62936       116 ------------------------------------WYEQASPAPLLVNPEALEPSLSVNGSDGMFKYE 148  Norway rat
8_pfamImport  60 --------------------------------------yqASPAPIIVNTETLDTVPYVNGTEIEYEFE 90  
Q6ZSU2       106 --------------------------------------aqASPAPIIVNTDTLDTIPYVNGTEIEYEFE 136  human
XP_005997201 153 --------------------------------------pkAKPPPIIVNTDSLEHDPYVNGTDGVYKYE 183  coelacanth
XP_011481761  94 --------------------------tghtpmytsaVSTLGNTPPVVVNTDTLDGSPYVNGTEGEIEYE 136  Japanese medaka
1_pfamImport  66 ----------------------lslsrsltcpllllISLQGNTPPVVVNTDTLDGSPYVNGTEGEIEYE 112 
BAE89987      67 --------------------------------------lkASPAPIIVNTDTLDTIPYVNGTEIEYEFE 97   crab-eating macaque
XP_020778562  92 -----------------------------mstghtpMYTSA-------------VSTLVNGTEGEIEYE 118  great blue-spotted mudski...
OCT65730     107 ------------------------------------WYEQAGAAPLLVNTDCLDPSSSVNGSDTLYKYE 139  African clawed frog
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