Conserved Protein Domain Family

pfam10599: Nup_retrotrp_bd 
Retro-transposon transporting motif
This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organisms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.
PSSM-Id: 371156
View PSSM: pfam10599
Aligned: 5 rows
Threshold Bit Score: 55.8382
Threshold Setting Gi: 1351657
Created: 11-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
XP_001383416  919 KEATPDPASVFGMNNSNAN-----------MGSREATPFAFGTGTGVSnp-------------------asVFGNPGNAI 968  Scheffersomyc...
Q6BZ26        940 KEGTPDPASIFGGGANNMNtsniqngvnglNKSAESSPFGFNAHQSTPdfkfangiqqpqfnsglpadmnnQSFNSTSGM 1019 Debaryomyces ...
XP_001486799  906 REPTPDPASIFGAGSSNT------------RELTPAAPLGFAT----------------------------QNQNPNTSF 945  Meyerozyma gu...
P49791       1378 GSGTANASSVFQFGSSTTNfn--------fTNNNPSGVFTFGASPSTP-----------------------AAAAQPSGS 1426 Norway rat
Q09904       1072 AGNTPNPSGSIN--NASQAfafgsgepsnpASNPPSTGFSFGA-------------------------------ATPSAF 1118 Schizosacchar...
XP_001383416  969 SMPAptagFGGTPAFafggvnggaggslapnqtptpPLQGRMIARMR-QRRR 1019 Scheffersomyces stipitis CBS 6054
Q6BZ26       1020 TPPT----LSTTPPI---------------------IKSNRKIAQMR-LRRR 1045 Debaryomyces hansenii
XP_001486799  946 TPPP----LSGNP-----------------------MVRNRKIAQMR-LRRR 969  Meyerozyma guilliermondii ATCC 6260
P49791       1427 GGFS----FSQSPASftvgsngk-----nmfsssgtSVSGRKIKTAV-RRKK 1468 Norway rat
Q09904       1119 NASA-----SQSPAPngiqfnlg------ssnsqtnAPPGRKIAVPRsRRKR 1159 Schizosaccharomyces pombe 972h-
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