Conserved Protein Domain Family
NMDAR2_C

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pfam10565: NMDAR2_C 
N-methyl D-aspartate receptor 2B3 C-terminus
This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family pfam00060 further upstream as well as the ANF_receptor family pfam01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites.
Statistics
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PSSM-Id: 402274
View PSSM: pfam10565
Aligned: 13 rows
Threshold Bit Score: 666.518
Threshold Setting Gi: 47209023
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001121809  919 HLFYWQLRFCFMGVCSGKPGMTFSISRGIYSCIHGVQIEE-NKsalnSPSATmkmnMNNTHSNILRLLRTAKNMTSVPGV 997  zebrafish
XP_017952758  758 HLFYWKLRYCFTGVCTGTPGLLFSISRGIYSCIHGVHIEEkKK----SPDFS----FTASQTNMLKLLRASKNIANLSNL 829  tropical claw...
XP_015150065  836 HLFYWKLRFCFTGICSDRPGLLFSISRGIYSCIHGVHIEEkKK----SPDFT----LTNSQTNMLKLLRTAKNMTNM-NP 906  chicken
XP_001506052  837 HLFYWKLRFCFTGVCTDRPGLLFSISRGIYSCIHGVHIEEkKK----SPDFN----LTGSQTNMLKLLRSAKNISNMSNL 908  platypus
Q12879        839 HLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEkKK----SPDFN----LTGSQSNMLKLLRSAKNISSMSNM 910  human
XP_006505636  840 HLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEE-RQsvmnSPTAT----MNNTHSNILRLLRTAKNMANLSGV 914  house mouse
XP_005810958  929 HWFYWQLRFCFMGVCSGQPGFVFSVSRGIYSCIHGVQIEEkSSsalnSPSAT----MNNTHSNIMRLLRTAKNMASLSGV 1004 southern plat...
XP_006637219  842 HLFYWRLRYCFTGVCSGTPGLLFSISRGIWSCIHGVHIEEkKK----SSDLD----FSSPQANMLKLIKSAKNMTTMSNL 913  spotted gar
XP_005460780  908 HLFYWRLRYCFTGVCSGRPGILFTISRGIWSCIHGVHIDMkKK----APELD----F-SPQANMLHLLKSAKSIAl---- 974  Nile tilapia
XP_022531677  836 HLFYWRLRYCFTGVCSGKPGLLFSISRGIWSCIHGVHIDMkKK----SSDLD----F-SPQANMLKLIKSAKQMTNMTNL 906  Mexican tetra
XP_006008257  732 HLFYWKLRFCFPGVCSGKPGFLFSISRGIYSCIHGVHIEEkKK-----SEFD----F-SNQTNMLKLLRTAKTMTNMSNL 801  coelacanth
CAG02690      729 HLFYWRLRYCFTGVCSGRPGLLFSISRGIWSCIHGVHIDMkKK-----TDLD----F-SPQDKMLKLIKSAKHMTNMSNL 798  spotted green...
CAF94353      607 HLFYWQLRFCFMGMCSGKPGLTFSISRGIYSCIHGVQIEE-NKstidSPSSTmkknMNNTHSNILRLLRTAKDMTAVPGI 685  spotted green...
NP_001121809  998 NG----SPHSALDYSH-R--ESAVYDISEHRRSLAgHS-DCKpp-pYLPEDnMFSDYVSEVERT--FGNLHLKDSNLYQd 1066 zebrafish
XP_017952758  830 NQsqcnSPKRTSDYIQ-R--NSLLMDMVLDKGNLS-YS-DNRp---FQQKD-VYSENTYDLAML--SGNHPKDNLNNYV- 897  tropical claw...
XP_015150065  907 SRi--nSPKRTADFIQ-R--GSLIMDMVMDKGNLI-FS-DNRs---FQTKDnFFGENMSELQTL--PGNRHKDNLNNYV- 973  chicken
XP_001506052  909 NPsrmnSPKRSTDFIQ-R--GSLIMDMVMDKGNMV-YS-DNRs---FQGKEnIFGDDMSELQTF--VANRHKDNLNNYV- 977  platypus
Q12879        911 NSsrmdSPKRAADFIQ-R--GSLIMDMVSDKGNLM-YS-DNRs---FQGKEsIFGDNMNELQTF--VANRQKDNLNNYV- 979  human
XP_006505636  915 NG----SPQSALDFIR-R--ESSVYDISEHRRSFT-HS-DCKsynnppCEEnLFSDYISEVERT--FGNLQLKDSNVYQd 983  house mouse
XP_005810958 1005 NG----SPHSALDFIR-R--DSSVYDISEHRRSLAgHS-DCKp--pYMPEDnMFSDYISEVERT--FGNLHLKDSNLYQd 1072 southern plat...
XP_006637219  914 NAsrinSPKRATDYMH-G--GPMMMDMVVDKGNFL-YA-DNRs---YPPKEaLYGETGSDLQTF--MGNRHKDNLNNYV- 982  spotted gar
XP_005460780  975 -----pSPKRNTVVVQ-----PSILDMMSGKGNSL-HT-LPQkg------pgLYS-NAVGPQGFlsLSGRHKNLLNNAAp 1035 Nile tilapia
XP_022531677  907 SGsrvnSPKRAGEFMHsA--GPMIMDLMSEKGNFV-YT-DNRs---YAQKD-IYGDS-SDIQSY--LANRHKDHLNNYI- 974  Mexican tetra
XP_006008257  802 NAsratSPKQTSDYVQ-R--GSLLMDMVVDKGGLM-YS-DNRs---FQPKEaHYGDNISEMQTF--ASNHHKDNLNNYV- 870  coelacanth
CAG02690      799 GGshmnSPKH--EFMHsA--GPMIMDMMAEKGNFI-YA-DNRs---YAPKDmIYGDN-SDLQSY--IANRHKDHLNNYI- 865  spotted green...
CAF94353      686 NG----SPHAALEYSH-SgcDSAIYDIQEHRRSLVgHPiDCKsappYLPEDnMFSDYISDVERT--FGNLPLKDNNLYQd 758  spotted green...
NP_001121809 1067 HYlHHHGGSelalgmsgPLPNRPRSLGSASSLEgGydcdsl-gggvapIFTTQPrqslthRNREKFDLIAGHPtq----- 1140 zebrafish
XP_017952758  898 FQ-GQHPLT--------LNESNPNTVEVAVSAE-P-------------KLNSRP------RQLWKKSVETLRQnq----- 943  tropical claw...
XP_015150065  974 FQ-GQHPLT--------LNESNPNTVEVAVTTE-A-------------KVNSRP------RQLWRKSVESLRQesvrqgq 1024 chicken
XP_001506052  978 FQ-GQHPLT--------LNESNPNTVEVAVSAE-S-------------KPNSRP------RQLWKKSVESLRQeslrqnp 1028 platypus
Q12879        980 FQ-GQHPLT--------LNESNPNTVEVAVSTE-S-------------KANSRP------RQLWKKSVDSIRQdslsqnp 1030 human
XP_006505636  984 HYhHHH---------------RPHSIGSTSSID-Glydc------dnpPFTTQP------RSISKKPLDIGLPs------ 1029 house mouse
XP_005810958 1073 HYlHHHGSTpgl---tgPPPNRPHSLGSASSLEgGmfdcdslgggvapIFTTQPcsalthRNMSKFDLLSGQTpps---g 1146 southern plat...
XP_006637219  983 FQ-GQHPLT--------LNESNPNTVEVAVSADaT-------------PGTTKP------RQLWKKSVETLRQsq----- 1029 spotted gar
XP_005460780 1036 FP-GQPKAP--------PHQTSPNKPQLSITNDnGqtrl-----tgagLTASKP------RALWKKSVETLKTqpsvvsp 1095 Nile tilapia
XP_022531677  975 FQ-GQHPLT--------LNESNPNTVEVAVSADaA-------------QTAAKP------RALWKKSVDTVRQsq----- 1021 Mexican tetra
XP_006008257  871 FQ-GQHPLT--------LNETNPNTVEVAVSSE-T-------------KVNSKP------RQLWKKSVETLRQsq----- 916  coelacanth
CAG02690      866 FQgGHHPLT--------LNDANPNTVEVAVNANsV-------------QTNAKPp-----RTLWKKSVDTLRSvpp--gp 917  spotted green...
CAF94353      759 HYlHHHPASalg--msgPPPNRPRSLGSTSSLDgGmfdcdslgggvapIFTTQPrpsmthRNTSKFDLIAGHTpa----- 831  spotted green...
NP_001121809 1141 sSFKSGL--PDLYGkFSFKGgasssgfiaghDRYCGgggvg----------------sggdDGNIRSDVSDISTHTVTYG 1202 zebrafish
XP_017952758  944 gSVNENG--TEESK-PSTKN-----------QRFLP-------------------------EDGHFSDVSEASSRATCHI 984  tropical claw...
XP_015150065 1025 gSQRENG--SEENRqLSVKS-----------QRYLP-------------------------EEIVHSDVSETSSRATCHM 1066 chicken
XP_001506052 1029 gSLRENV--SEENRaHSLKS-----------PRYLP-------------------------EEVAHSDISEASSRAPCHL 1070 platypus
Q12879       1031 vSQRDEA--TAENRtHSLKS-----------PRYLP-------------------------EEMAHSDISETSNRATCHR 1072 human
XP_006505636 1030 -SKHSQL--SDLYGkFSFKS-----------DRYSGh------------------------DDLIRSDVSDISTHTVTYG 1071 house mouse
XP_005810958 1147 qSFKGGL--PDVYGkFSFKGgasss-tyipgPSYCGgrg--------------------ddDGNIRSDVSDISTHTVTYG 1203 southern plat...
XP_006637219 1030 gSVQDTL--PPDPR-MSMKS-----------QRYLP-------------------------EEAAQSDISDCSSRAQSYK 1070 spotted gar
XP_005460780 1096 gHSPAp---ASGPGpPQMKS-----------QRYLP-------------------------EDPQHSDLSECSSRPPSHK 1136 Nile tilapia
XP_022531677 1022 --gPDTL--APDPR-LSMKS-----------QRYLP-------------------------EEAAHSDISDCSSRATSYK 1060 Mexican tetra
XP_006008257  917 gSLKEKV--PEEKR-HSVKN-----------QRYIP-------------------------EEVVHSDVSDTSSRATSHK 957  coelacanth
CAG02690      918 sPMPDML--MPDPR-MSMKS-----------QRYLP-------------------------EETAHSDISDCSSRAASYK 958  spotted green...
CAF94353      832 dSNQVGFkgANVYGrFSFK----------------GgasstgliggqdrycvgggggsggdDGNIRSDVSDISTHTVTYG 895  spotted green...
NP_001121809 1203 NLEGHSk--RRKQYRDSLKKRPASAKSRREQDEIEL-GFRRRPhhtihhhhHHHPatqahrsatppver--ksqrggnct 1277 zebrafish
XP_017952758  985 DSENNN---KHHKSKDNLKKRSVSSKYPRDCSEVEL-SYLKLK--------HGSN------------------------- 1027 tropical claw...
XP_015150065 1067 EPENNN---KHHKTKDNFKKRTVASKYPKDCSEVEL-TYLKTK--------QSSP------------------------- 1109 chicken
XP_001506052 1071 EPENNH---KHHKTKDNFKKRSGASKFPKDCSEVEL-TYLKTQ--------ASAP------------------------- 1113 platypus
Q12879       1073 EPDNS----KNHKTKDNF-KRSVASKYPKDCSEVER-TYLKTK--------SSSP------------------------- 1113 human
XP_006505636 1072 NIEGNAakrRKQQYKDSLKKRPASAKSRREFDEIEL-AYRRRPprspdhkrYf--------------------------- 1123 house mouse
XP_005810958 1204 NLEGNAk--KRKQYRDSLKKRPASAKSRRELDEIEL-GYRRKPyhishhhyHsqrsvsppllpserk--rgggggnnngn 1278 southern plat...
XP_006637219 1071 DPDNNQ---KHHKPKDNLKKRSMTSKYPRDCSEVEL-SYLKSKq-------GGS-------------------------- 1113 spotted gar
XP_005460780 1137 DSDSMAa-rGGFKPINQLRKRGGGGGGAG----------------------GGGG------------------------- 1168 Nile tilapia
XP_022531677 1061 DPDNN----KHLKPKDNLKKRSMTSKYPRDCSEVEL-SYLKNKq-------GGSG------------------------- 1103 Mexican tetra
XP_006008257  958 NADNNK---KHHKPKNNFKKRSVTSKYPRDCSEVEL-SYLKSKq-------SST-------------------------- 1000 coelacanth
CAG02690      959 DPENN----KHMKPKDNLKKRTVTSKYPRDCSEVEL-SYLKSKqvssgtnqAGRG------------------------- 1008 spotted green...
CAF94353      896 NLEGNNk--RRNQYRDSLKKRPASAKCRREQDEIELsGLRRRPhhh--tvhHHFPhgpqahrkvspplerkrggggnssp 971  spotted green...
NP_001121809 1278 sylfRDKENLRD--------FYVDQFRAKEGASp-WD-LDLSDAPGMGGG----VGLGggSCGGVVssggaggactSLVP 1343 zebrafish
XP_017952758 1028 ----RDKVYTIDgdk--epsFIMDQPKYSENSP--DQdDDYPDVYQDHND----NYRK--AEALQP----------DRTP 1083 tropical claw...
XP_015150065 1110 ----RDKIYTIDadk--epgFRLDTPQYIENIVl-PEtIEYPDVYQDHND----NYRKaeHA--------------NRTP 1164 chicken
XP_001506052 1114 ----REQIYTIDadq--epsFHLDPPPYVENVVl-PEdPAFPEVYRDPND----NFRPggDSPLPA----------NRTP 1172 platypus
Q12879       1114 ----RDKIYTIDgek--epgFHLDPPQFVENVTl-PEnVDFPDPYQDPSE----NFRKg-DSTLPM----------NRNP 1171 human
XP_006505636 1124 ----RDKEGLRD--------FYLDQFRTKENSPh-WEhVDLTDIYKERSD----DFKRdsVSGGGPc--------tNRSH 1178 house mouse
XP_005810958 1279 sylfREKESVRD--------FYLDQFRPKEGVPq-WEhVDLTEGPGn-------------RDGGVPtc-------tSLVP 1329 southern plat...
XP_006637219 1114 ------KIYTIDter--elgLHTDQHHFRENRAl-PEdLEYSEMYQDHND----NYRKp-EPVIHL----------NSSP 1169 spotted gar
XP_005460780 1169 ----ASKIYSIDsdq---asLQSAPPYQRDSQGgsDEhPYPPDLFPPDSTyphtHSHQsdAPILQL----------SASL 1231 Nile tilapia
XP_022531677 1104 ----REKIYTIDsdr--elsLHSDPLHYRESRGlaADdLDFPEIYSDHND----NYRKcdQPIIHL----------NSSP 1163 Mexican tetra
XP_006008257 1001 ----RDKIYTIDtvterepsFHIEPHYYREAVAi-PEdIDFPEIYQDHNE----NYRKp-EAVVHI----------NRTP 1060 coelacanth
CAG02690     1009 ----GDKIYTIDsd----lsLHSDPIHYRESRGpaADdLEYPEIFSDHSD----NYRKceQPIIHL----------NSSP 1066 spotted green...
CAF94353      972 flfrKEKENLRD--------FYADQFRSKEGKAk-WE-QE-----GGSGG----SGVGdgSSGAIC-------------- 1018 spotted green...
NP_001121809 1344 MEDF----------------LKGKS-------------KKTECKGgmggGSPGQQGHACWEKGIGgvggla--ggdweCR 1392 zebrafish
XP_017952758 1084 LHSEgrlpnn-----diqykLFSKH-------------YSSKEKN----TSMSESNDRHRQNSTH-------------CR 1128 tropical claw...
XP_015150065 1165 LHNEdslpn------ndqykLYAKH-------------YSLKDKN----ASLVDMNDRYRQNSTH-------------CR 1208 chicken
XP_001506052 1173 LHNAdgppd------ndqykLYPKH-------------YGTKDKN----ASHGEANDRFRSNSTH-------------CR 1216 platypus
Q12879       1172 LHNEeglsn------ndqykLYSKH-------------FTLKDKG----SPHSETSERYRQNSTH-------------CR 1215 human
XP_006505636 1179 L-----------------------K-------------HGTGDKHgvvgGVP-----APWEKNLTnvdwed-rsggnfCR 1216 house mouse
XP_005810958 1330 VEDF----------------LKSKP-------------KKSDSKGgpgsgl---------------------aggeweCR 1359 southern plat...
XP_006637219 1170 LHADditpnn-----enkynLYSKH-------------YSLKEKN----VSPHETNDRYKQ--TH-------------CR 1212 spotted gar
XP_005460780 1232 LHHShsaeadlhslkdkkysTYT-H-------------SSVKEKVggsfEAPSAGPGTQSVRPGH-------------CR 1284 Nile tilapia
XP_022531677 1164 LHHTdadll--------pdnaYNKH-------------YSVKDKN----ASPHESNDRFKQ--TH-------------CR 1203 Mexican tetra
XP_006008257 1061 LHNEdslpnn-----ekkynLYSKH-------------YSLKEKN----FSPFEINDRLKQASTH-------------CR 1105 coelacanth
CAG02690     1067 LHHTdsdlv--------peptYAKH-------------YNMKEKNl--sLSPHESIDRYKQ--TH-------------CR 1108 spotted green...
CAF94353     1019 ------------------------KslvpvedflkgisRKPEGKCg--lVSAGQQAHTCWEKGGSglggggiaggdweCR 1072 spotted green...
NP_001121809 1393 SCHSggvgsggskpvcmhggggagGYpAAGgV-----------GGSS-GGsgqissrpssATCkRCDSCK-KPGNLYDIS 1459 zebrafish
XP_017952758 1129 SCLS--------------------NM-PNY-T-----------GHYT-AR----------SPY-KCDDCL-HIGKLYDID 1162 tropical claw...
XP_015150065 1209 SCLS--------------------NL-PTY-A-----------GHYS-GR----------SPY-KCDACL-RMGNLYDIE 1242 chicken
XP_001506052 1217 SCLS--------------------NL-PSY-P-----------GPHS-SR----------SPY-KCDACL-RMGNLYDID 1250 platypus
Q12879       1216 SCLS--------------------NM-PTY-S-----------GHFT-MR----------SPF-KCDACL-RMGNLYDID 1249 human
XP_006505636 1217 SCPSklh------------------nySSTvA-----------GQNS-GR----------QACiRCEACK-KAGNLYDIS 1255 house mouse
XP_005810958 1360 NCRAsggkqis-------ihggggGYsSGMgC-----------GSSA-GGsrp-----ssATCmRCEGCK-KTGNLYDIS 1414 southern plat...
XP_006637219 1213 SCLS--------------------KV-PNY-S-----------GHFA-VR----------SPYnRCEACL-HMGNLYDIS 1247 spotted gar
XP_005460780 1285 SCLT--------------------KL-SGY-S-----------GLYT-VR----------SPQaRCDACA-HLGNLYDIS 1319 Nile tilapia
XP_022531677 1204 SCLS--------------------KV-PNYpT-----------GPYApMR----------SPYnRCEACL-HMGNLYDIS 1240 Mexican tetra
XP_006008257 1106 SCLS--------------------KM-PNY-T-----------GHFA-MR----------SPYnRCEACL-HMGELYDIS 1140 coelacanth
CAG02690     1109 SCLS--------------------KVtASYpPggsytsnvsasASAT--R----------SPYnRCEACL-HTANLYDIN 1155 spotted green...
CAF94353     1073 NCHSvchhsg---------glgggSTcSASgA-----------GGTtsr--------pssASCkRCDSCKiQPSNLYNIS 1124 spotted green...
NP_001121809 1460 EDNLLLDQIAGKHplesgkggGG-----TGAQTQV-----------------------------QRRKfgpggkvLRRQH 1505 zebrafish
XP_017952758 1163 EDQMLHEAANSMH--------SEdfyehNWLENNAlhf-----------------------qkkNKLR-------INRQH 1204 tropical claw...
XP_015150065 1243 EDQMLQDTTNLSL--------PEeiyghSWSQNNAlqy-----------------------hkkNKLR-------ISRQH 1284 chicken
XP_001506052 1251 EDQMLQESGNPAT--------PEatfepEWGRSSTlql------------------------qkNKLR-------MNRQQ 1291 platypus
Q12879       1250 EDQMLQETGNPAT--------GEqvyqqDWAQNNAlql------------------------qkNKLR-------ISRQH 1290 human
XP_006505636 1256 EDNSLQELDQPAApvavssnaSTtkypqSPTNSKAqk--------------------------kNRNK-------LRRQH 1302 house mouse
XP_005810958 1415 EDNN-----HPLEqmgggkggGGvgcmaAGPQAQSqa--------------------------qQRRKsggfgkqLRRQH 1463 southern plat...
XP_006637219 1248 EDQMLQEAISPLN--------QDemfshYWPQTDGphv-----------------------qkrNRLR-------LSRQH 1289 spotted gar
XP_005460780 1320 EDHL-----HSHYshthphphSAdmfthYLPQSELglvgegdglvshfeptpsspsplptsssaQHLQ-------LSRQH 1387 Nile tilapia
XP_022531677 1241 EDQMLQEAILSPTm------hPDdafghYWPQTDGphv-----------------------qkrNRLR-------LSRQH 1284 Mexican tetra
XP_006008257 1141 EDQMLQEITGAIH--------PEevyghQWIQSDVaql-----------------------qkrNKLK-------LTRQH 1182 coelacanth
CAG02690     1156 EDQLLTDPLGSPTlhhqqqqqADemfglYWPQTDGphv-----------------------qkrNRLR-------LSRQH 1205 spotted green...
CAF94353     1125 EDNNMVfagg--------kgsAGp----SQTQTQV-----------------------------QRRKlgpggrvLRRQH 1163 spotted green...
NP_001121809 1506 SYDTFv-ELQKEGAGRMggfgggg--------gasmlppP----------RSVSLKDKD---RYmEGASPYAQMFEQyag 1563 zebrafish
XP_017952758 1205 SCDNI--NKPREQDLGR----------------------Pp---------RSVSLKEKE---RY-IQDSPFAKFLIV--- 1244 tropical claw...
XP_015150065 1285 SFDNIa-DKSREIDLGR----------------------Ps---------RSISLKDKE---KF-LQSSPYASMFSV--- 1325 chicken
XP_001506052 1292 SYDNIl-DKPRELDLGR----------------------Ps---------RSISLKEKE---RL-LECSSFGSLFGV--- 1332 platypus
Q12879       1291 SYDNIv-DKPRELDLSR----------------------Ps---------RSISLKDRE---RL-LEGNFYGSLFSV--- 1331 human
XP_006505636 1303 SYDTFv-DLQKEEAALA----------------------P----------RSVSLKDKG---RF-MDGSPYAHMFEM--- 1342 house mouse
XP_005810958 1464 SYDTFv-DLQKEESGGMgslmgglgggmggpgmggmlppP----------RSVSLKEKE---RYmEENSPFAHIFERhgg 1529 southern plat...
XP_006637219 1290 SFDNIl-EKPKDIDLGR----------------------Pa---------RSVSLKEKD---RF-LEDSPYANMFSM--- 1330 spotted gar
XP_005460780 1388 SYENVlpD-------GI----------------------PerqsqahphmRGLSLPDRDrerELtLDEGAYANVLTM--- 1435 Nile tilapia
XP_022531677 1285 SFDNImlEKPKEIDLNR----------------------Pa---------RSVSLKEKD---RF-LEDSPYANLFNI--- 1326 Mexican tetra
XP_006008257 1183 SFDNIl-EKPKEADLGR----------------------Pa---------RSVSLKEKD---RF-LDESPYANMFNI--- 1223 coelacanth
CAG02690     1206 SFDNImlEKPKDVDVGR----------------------Pa---------RSVSLKEKD---RFaTSDSHYANLFNM--- 1248 spotted green...
CAF94353     1164 SYDTFv-DLQREGANRMgglggsm---------sgpfpqP----------RSVSLKEKD---RFiEGSSPYSHMFEsgl- 1219 spotted green...
NP_001121809 1564 geretsyfgdrgkg------ggssfslfrggegglhrRSvgERDMR--DRDrgmmgggv-ggtrgvgtYSL--------- 1625 zebrafish
XP_017952758 1245 -------------------------------------PP--EKLLG--NNT-----------------ALFtdslkeskr 1266 tropical claw...
XP_015150065 1326 -------------------------------------PS--SKLLS--NKA-----------------SLLthaledskr 1347 chicken
XP_001506052 1333 -------------------------------------PQ--SQMAG--NQS-----------------SLYsqtledgrr 1354 platypus
Q12879       1332 -------------------------------------PS--SKLSG--KKS-----------------SLFpqgledskr 1353 human
XP_006505636 1343 --------------------------------------PagESSFA--NKSsvttaghh--hnnpgsgYML--------- 1371 house mouse
XP_005810958 1530 serererdrdplfyggesqkgsgspfglfrggeglhrRSigERDMR--DRSlmegg--------ggaaFSL--------- 1590 southern plat...
XP_006637219 1331 -------------------------------------KP--DKLFS--SKS-----------------MLFnhnleeskr 1352 spotted gar
XP_005460780 1436 -------------------------------------RS--DRPLS--SRSppsps--------pshhHSLdtpmplprr 1466 Nile tilapia
XP_022531677 1327 -------------------------------------KS--DKLFG--SRS-----------------MLFnhnleeskr 1348 Mexican tetra
XP_006008257 1224 -------------------------------------KP--EKLLS--SKA-----------------SIFnhnleeskr 1245 coelacanth
CAG02690     1249 -------------------------------------RPysGRLFGtsSKS-----------------MMFnhnleeskr 1274 spotted green...
CAF94353     1220 -----------------------------------hqRStgEKDLR--DRDravmggggggfsrgagtYSL--------- 1253 spotted green...
NP_001121809 1626 SKSLYPDKVNQNPFI-PT-----FGDD--Q---CLLHGAKSYYIKKQQAqpqqqqtpqqqQqqllnnSR--AD---FRGS 1689 zebrafish
XP_017952758 1267 SKSLYPDNSSDNPFL-HS-----YQET--Q---KLSHGRSSSDIYKQSS-----------L------TKarNDn-yLRSS 1317 tropical claw...
XP_015150065 1348 SKSLYPVHSEDNPFL-HS-----YRDD--Q---HLSLRRNPADLYKYSL-----------P------SRgrNDn-yFRSS 1398 chicken
XP_001506052 1355 SKSLYPDHSSDNPFL-RS-----YRDD--Q---HLVIGRCPSDPYRQSL-----------P------SQarNEn-yWRSS 1405 platypus
Q12879       1354 SKSLLPDHTSDNPFL-HS-----HRDD--Q---RLVIGRCPSDPYKHSL-----------P------SQavNDs-yLRSS 1404 human
XP_006505636 1372 SKSLYPDRVTQNPFI-PT-----FGDD--Q---CLLHGSKSYFFRQPTVag---------------aSKtrPD---FRAL 1422 house mouse
XP_005810958 1591 SKSLYPDRVNQNPFI-PT-----FGDD--Q---CLMHGAKQYYLTKQQq----------qQqqvaqnSR--GD---FRSQ 1644 southern plat...
XP_006637219 1353 SKSLYPDHTSENPFL-HS-----LRED--Q---RLVHGRSSSDIYKQLV-----------P------VKsrNDn-nLRSS 1403 spotted gar
XP_005460780 1467 SKSLFPDRPSHNPFL-QSapgtaQRDPasQattRMPQRNSAHELYKQRM-----------PvsltlgNHgnHHfnqHGGQ 1534 Nile tilapia
XP_022531677 1349 SKSLYPDHTTDNPFM-QA-----VRDD--A---RLVHGRSSSDIYKQLA-----------P------IKtrNEn-nLRSS 1399 Mexican tetra
XP_006008257 1246 SKSLYLDHSSENPFM-HS-----YHED--Q---QLVHGRSSSDIYKQ--------------------SKarNDn-nLRSS 1293 coelacanth
CAG02690     1275 SKSLYPTHGSENPFLsYS-----LRDDssS---RLLHGRSSSDIYKQLAvaspagiigvpP------NKtrNDannQRSS 1340 spotted green...
CAF94353     1254 SKSLYPDKVNQNPFI-PT-----FGDD--Q---CLLHGAKPYYVKKPQTq---------qPqqllnnSRggGD---FRTS 1310 spotted green...
NP_001121809 1690 MGVTSYLPASAtsgvlsnvaPRFPKELCLGgp---lgNHHGGGPSNNKLLSardg-lgmgQGQR-PFNGS--SNG-HVYE 1761 zebrafish
XP_017952758 1318 IKSTSSYSSRD---------GRVPNDMCAS-------EYALPYVTSNNSVY---------SAPR-VVNSC--SNR-RVFK 1368 tropical claw...
XP_015150065 1399 IKSTASYCSRD---------GRIHNDMYIS-------EHVLPYVANRNSVY---------STPR-VLNSC--SNR-RVYK 1449 chicken
XP_001506052 1406 LRSTASYSSRD---------SRVHNDVYIS-------EHAMPYVANKNSLY---------SAPR-VFNSC--SNR-RIYK 1456 platypus
Q12879       1405 LRSTASYCSRD---------SRGHNDVYIS-------EHVMPYAANKNNMY---------STPR-VLNSC--SNR-RVYK 1455 human
XP_006505636 1423 VTNKPVVSALHga-----vpGRFQKDICIG-------NQSNPCVPNNKN-------------PR-AFNGS--SNG-HVYE 1473 house mouse
XP_005810958 1645 LSATSYLPASAtagvmpnvpPRFPKELSLGg-----mNHHGSMLAVGP--------------PR-PFNG---SNG-HVYE 1700 southern plat...
XP_006637219 1404 VKSTASYCSRD---------GRVPNDMYIS-------EHAMPYVANKTSAY---------SAPR-VLNSC--SNR-RVYK 1454 spotted gar
XP_005460780 1535 VDQQAFYPPQE---------PPV------V-------AYMVPPAASQPMSYv--------TAPR-ASSAG--GNRpRLYR 1581 Nile tilapia
XP_022531677 1400 IKSTTSYCSRD---------GRIPNDMYIS-------EHVMPYVANKPSAY---------SAPR-VLTSSqfSNR-RVYK 1452 Mexican tetra
XP_006008257 1294 IKSTASYCSRD---------GRIPNDMYIS-------EHVMPYVANKNSVY---------SAPR-VLNSC--SNR-RVYK 1344 coelacanth
CAG02690     1341 VKSTTSYCSRD---------GRIANDMYNK-------EHVTPYSANKTSAY---------PGQRgVLNSTqfNNR-RVYK 1394 spotted green...
CAF94353     1311 MGAASYLPASAtagvmsnvaPRFPKELCLGgagghigNHHG----SNKLLPggrdtlglgQGQR-SFNGA--SNG-HVYE 1382 spotted green...
NP_001121809 1762 KLSSIESDV 1770 zebrafish
XP_017952758 1369 KMPSIESDV 1377 tropical clawed frog
XP_015150065 1450 KMPSIESDV 1458 chicken
XP_001506052 1457 KMPSIESDV 1465 platypus
Q12879       1456 KMPSIESDV 1464 human
XP_006505636 1474 KLSSIESDV 1482 house mouse
XP_005810958 1701 KLSSIESDV 1709 southern platyfish
XP_006637219 1455 KMPSIESDV 1463 spotted gar
XP_005460780 1582 RMPSIESDV 1590 Nile tilapia
XP_022531677 1453 KIPSLESDV 1461 Mexican tetra
XP_006008257 1345 KMPSIESDV 1353 coelacanth
CAG02690     1395 KIPSLESDV 1403 spotted green pufferfish
CAF94353     1383 KLSSIESDV 1391 spotted green pufferfish
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