2JH1


Conserved Protein Domain Family
MAR_sialic_bdg

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pfam10564: MAR_sialic_bdg 
Sialic-acid binding micronemal adhesive repeat
This domain is a novel carbohydrate-binding domain found on micronemal proteins. Micronemal proteins (MICs) are released onto the parasite surface just before invasion of host cells and play important roles in host cell recognition, attachment and penetration. Toxoplasma gondii can infect and replicate within all nucleated cells. This domain interacts with sialylated oligosaccharides; the protein in Toxoplasma gondii is a monomer but several MAR domains are carried on the protein. Each MAR domain contains one central sialic acid-binding pocket.
Statistics
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PSSM-Id: 402273
View PSSM: pfam10564
Aligned: 8 rows
Threshold Bit Score: 121.021
Threshold Setting Gi: 149242361
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2JH1_A    25 LDQRCQEIAAELCQSG--LRKMC--VpsSRIVARNAVGIt-HQNTLQWRCFDTASLLESNQEnngVNCVDDCGHTIPCPG 99  
ESS29490 543 LNAFCTTQFQKLCSETidGGRYCg-V--SGAVARFGPGG--HDSDSQWRCYEESIMNTTTKG---VQCMDDCGNQMQCVG 614  Toxoplasma gondii VEG
ESS29489 167 VDYYCAKRFEQQCAKGvlGKTYCt-D--GLVVGRYVSQG--SKLEAGWHCFKGAEIAHSQRQ---VKCVDNCGNLMKCFG 238  Toxoplasma gondii VEG
ESS32031  57 LDSYCHNRYKQLCDGG--NKNFC--D--KTGVARYGTGIq-SQQTAEWRCYFAEVLKPSGRK---VQCVDDCGNYFPCLG 126  Toxoplasma gondii VEG
ESS33997  41 LDQRCQEIAAELCQGG--LRKMCvpS--SRIVARNAVGIt-HQNTLEWRCFDTASLLESNQEnngVNCVDDCGHTIPCPG 115  Toxoplasma gondii VEG
PUA88252 277 MDNYCQTEMDQMCRVGk-WTTYC--Y--QLWLSRMVSTE--EDEEPKWRCYPFALLNFSDLS----TCIDGCSNRVPCHG 345  Toxoplasma gondii ...
CEL71697 345 LDTMCQDAMDEECRKGk-QTEDC--F--GLWLARYELESs-PGGAGAWRCYPESRLDFTQLS----SCIDGCGNPISCRG 414  Toxoplasma gondii VEG
AFD54620 280 IDDACQKLFNCHCKK---DKKFC-----TTVVARKDRGRagSQNDAEWRCYSLEELDFQKTN---PSCIDECGNELPCQG 348  Toxoplasma gondii
2JH1_A   100 GVHRQNSNHATRhEILSKLVEEGV 123 
ESS29490 615 AVSVKTVATPPL-RALSAFISQRR 637  Toxoplasma gondii VEG
ESS29489 239 DVNSSQTAKVAM-PGMDEWIDKRK 261  Toxoplasma gondii VEG
ESS32031 127 VVDPNDTFHATAhNQILNFIKDGV 150  Toxoplasma gondii VEG
ESS33997 116 GVHRQNSNHATRhEILSKLVEEGV 139  Toxoplasma gondii VEG
PUA88252 346 APSPTSTLTTEF-SKLKTIAENia 368  Toxoplasma gondii TgCATBr9
CEL71697 415 QPAEVSPAFIDL-PALDKVAGDMS 437  Toxoplasma gondii VEG
AFD54620 349 AVPEESTHHITW-TKLPSKIDEAT 371  Toxoplasma gondii
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