Conserved Protein Domain Family
MTP18

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pfam10558: MTP18 
Mitochondrial 18 KDa protein (MTP18)
This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis. Overexpression studies suggest that MTP18 is required for mitochondrial fission.
Statistics
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PSSM-Id: 402268
View PSSM: pfam10558
Aligned: 78 rows
Threshold Bit Score: 170.494
Threshold Setting Gi: 81999753
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBQ70065      81 PTRYAAYLMRLKTVILASSRYVAYSSDIGEAFRPLTRPEVVRGAYAISWTYILGDVLYAGYKAAKQYEALASttfSSSEG 160 Sporisorium rei...
EDP43569      24 lgRYSAYTMRLKTLVTSVSRYIAYTSDVGEAFRPLTRPIVVTSAYAISWAYIFTDVGWTCWQAAKLQDR----------- 92  Malassezia glob...
GAC75419      82 PSRYAAYAMRLKTVIVASSRYVAYSSDIGEAFRPLTSPAFVRGAYAVSWTYILGDVVYAGYKAAQQYEALASttfSKSGP 161 Moesziomyces an...
XP_012191542  84 pgRYAAYAARLKTAVGSSLRMSAYTSEMGEALRPLTKPWVVRGAYAVSWTYIIVDVAYAGFKAAKQYESLASttfSATGP 163 Pseudozyma hube...
XP_016292124  80 pERYAAYFMRLKTVIIASSRYVAYTSDIGEAFRPLTKPAVVKAAYGISWTYILGDVFYAGYKAAKQYEALASttfTSSSG 159 Kalmanozyma bra...
EGF76981       9 PLRILGYAGRLRNFVTAGSRYLAYTSDMGEAFRPVVPRSVVNAAYGVSFAYVGIDVAYEGYKSSLRGDSPME-------- 80  Batrachochytriu...
KDE03011      30 SARYLAYLARIRPVLQPMTRYLAYTSDVGESVRPIVNPKMVTGAYGVSWAYLVGDVAYEGYKARLRANENCP-------- 101 Microbotryum ly...
EFP75483      23 AARYLGLVARIRPLLIPASRYLAYTSDVGEAFRPVVNPKVVTSAYGISIGYVVGDVAYEGWKGHLQAQGDPD-------- 94  Puccinia gramin...
EFC35371      37 SLRYLGYLGRLKTAIVAGARYLAYTSDVGEAFRPIVHPLIVRAGYGISWAYVLGDVGIQTYREKEKGSSTNT-------- 108 Naegleria gruberi
EPB90166      38 NARYLAYAGRLRTALVASSRYLAYTSDVGEAFRPIVPPAVVTAAYGISWLYLGLDVSYEGYKSHHAGQENAV-------- 109 Mucor circinell...
CBQ70065     161 PLQEFEtkaakyansalesikenlplekvldaktlaalspsekvelkkrhtqrlaeqGHHAGVDPTKVSEVTHVGL-T-- 237 Sporisorium rei...
EDP43569      93 -----------------------------------------------------------------DSPTLASDIAW-I-- 104 Malassezia glob...
GAC75419     162 VQELESeaaqladkaltsarenlplekllda-ktlnalsptekvelrkrhverlaeqGDHAGVDPNQVSEATHVGV-V-- 237 Moesziomyces an...
XP_012191542 164 VQELETeaaklanqtlssvrenlpleevlds-ktlsalspsekvelrkrhtqrlaehGRHAGVDPSKVSEVTHVGM-T-- 239 Pseudozyma hube...
XP_016292124 160 PLQELEteaaryadkalssvkqnlpleklldhktlstlsptekvelrkrhtqrlaeaGQHAGVDPNQISEVTHVGL-T-- 236 Kalmanozyma bra...
EGF76981      81 -----------------------------------------------------------------------------Vtr 83  Batrachochytriu...
KDE03011     102 -----------------------------------------------------------------------EAVSTvVgl 110 Microbotryum ly...
EFP75483      95 ------------------------------------------------------------------------DNLV-Ial 101 Puccinia gramin...
EFC35371     109 -----------------------------------------------------------------------------Vlr 111 Naegleria gruberi
EPB90166     110 -----------------------------------------------------------------------------Vat 112 Mucor circinell...
CBQ70065     238 -VVRQAVFQSIASMALPAFTIHSIVRYSAP-LFAKA--KSQRIRAAGPTVAGLMFVPALPFLFDEPVEHVI 304 Sporisorium reilianum SRZ2
EDP43569     105 -AARRGAFQSLASLVLPAVTIHSVVKHSAH-LFAKF--KSSRVRVAGPTAAGLLVVPLLPIVFDDPVETVV 171 Malassezia globosa CBS 7966
GAC75419     238 -MARRAVFQSIASMALPAFTIHSIVRYSAP-VFAKA--KSQRIRAAGPTVAGLMFVPALPFLFDEPVEHVI 304 Moesziomyces antarcticus...
XP_012191542 240 -VARQAVFQSIASMALPAFTIHSIVKYTAP-VFAKA--KNHRIRAFGPTAAGLMFIPALPFLFDEPVEHVV 306 Pseudozyma hubeiensis SY62
XP_016292124 237 -MARQAVFQSIASMALPAFTIHSIVRYSAP-LFAKA--KSQRIRAAGPTVAGLMFVPALPFLFDEPVEHVI 303 Kalmanozyma brasiliensis...
EGF76981      84 tVVERTIFQGLASLLLPAITIHSVVDLTTK-ALKNT--SINALKRWGPTAAGLAVLPVLPILLDRPVEYVM 151 Batrachochytrium dendrob...
KDE03011     111 nVAKRAIFQCVASMLFPSLTIHAIVRYTAI-AVKKAnvKSIAVRRWLPSALGLGFIPALPFIFDEPVEHVV 180 Microbotryum lychnidis-d...
EFP75483     102 kVARRAAFQGTASMLLPALTIHSAVRYSKKmIFSKM--ANPRIHSIGPTAVGLGIIPFLPTLFDEPVEHLV 170 Puccinia graminis f. sp....
EFC35371     112 tATKTAIFQSTASMILPMITIHQTVHVVSA-ILKKVgyKSKVI----PTISGLAVIPALPFMFDHPVEHFV 177 Naegleria gruberi
EPB90166     113 tMVKRGVFQSLASMAFPMMTIHSIVKYSAY-GFKNV--KNAKVKAWGPTLLGLGIVPFLPYIFDEPIEHIV 180 Mucor circinelloides f. ...
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