Conserved Protein Domain Family
KASH

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pfam10541: KASH 
Nuclear envelope localization domain
The KASH (for Klarsicht/ANC-1/Syne-1 homology) or KLS domain is a highly hydrophobic nuclear envelope localization domain of approximately 60 amino acids comprising a 20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes. During meiotic prophase, telomeres cluster to form a bouquet arrangement of chromosomes. SUN and KASH domain proteins form complexes that span both membranes of the nuclear envelope. The KASH domain links the dynein motor complex of the microtubules, through the outer nuclear membrane to the Sad1 domain in the inner nuclear membrane which then interacts with the bouquet proteins Bqt1 and Bqt2 that are complexed with Bqt4, Rap1 and Taz1 and attached to the telomere. SUN domain-containing proteins are essential for recruiting KASH domain proteins at the outer nuclear membrane, and KASH domains provide a generic NE tethering device for functionally distinct proteins whose cytoplasmic domains mediate nuclear positioning, maintain physical connections with other cellular organelles, and possibly even influence chromosome dynamics.
Statistics
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PSSM-Id: 402255
View PSSM: pfam10541
Aligned: 36 rows
Threshold Bit Score: 43.7004
Threshold Setting Gi: 958686637
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002593504  2017 RIGRLCVWLLPLLfLLLLLFFLLSSLFPGGmlgMllgwERGSCHLQNSFRQSWRFMLRH-RSPPPI 2081 Florida lancelet
XP_007236898   599 hlvdVLRSRVMLY-ILLALLLVVVIWPPAV---L----KDNQCHRSNTLERSFHFALRYvNGPPPT 656  Mexican tetra
XP_015196396   576 vlLRLAKAALFLF-LSLALVLALLRQLPAG---A----SDPRCHRANTFARSLRLMLHYvNGPPPT 633  spotted gar
XP_014693785   419 pgapapaSRRPLT--FLLLLFLFLLLVGAT---VllplSGDPCSSPARLARTPYVVLSYvNGPPPV 479  ass
10_pfamImport    1 -FWRVVKASVPFY-IFFFFIYFLLWLSSASciiD----DRTICLQRNNLHYSFTPLLTWtDGPPPT 60  
EFX72496      1040 W-WRIVRAALPFH-LALIALLLAACVM-----------EPSCCNYLNTFGSSLVPKLSYlGGPPPI 1092 common water flea
XP_002433079   383 WIWRLIRCALPFH-IALIALWCVAYLM-----------ESRCCDSLNNLESSLSPVLRYdFGPPPV 436  human body louse
XP_008201870  1590 WVWRILRAALPFQ-LALVALFCAACLL-----------EPHCCEASNSLNLSLTPQLRYvRGPPPV 1643 jewel wasp
EDW04379       405 WAWRIARAAVPMQ-LALFTFFCAACMM-----------QPNCCDNLNNLSMSFTPQLRYiRGPPPI 458  Drosophila grimshawi
VVC95079       176 WVWRVLRSSIPIQ-LCLVALLLAAWLVE----------RPRCCDALNSLAQTLTPQLRYvRGPPPV 230  Leptidea sinapis
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