Conserved Protein Domain Family
Hist_rich_Ca-bd
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pfam10529: Hist_rich_Ca-bd 
Histidine-rich Calcium-binding repeat region
This is a histidine-rich calcium binding repeat which appears in proteins called histidine-rich-calcium binding proteins (HRC). HRC is a high capacity, low affinity Ca2+-binding protein, residing in the lumen of the sarcoplasmic reticulum. HRC binds directly to triadin. This binding interaction occurs between the histidine-rich region of HRC and multiple clusters of charged amino acids, named as the KEKE motifs, in the lumenal domain of triadin. The region in which this repeat is found in many copies is long and variable but is the acidic region of the protein. There is also a cysteine-rich region further towards the C-terminus. HRC may regulate sarcoplasmic reticular calcium transport and play a critical role in maintaining calcium homeostasis and function in the heart. HRC as a candidate regulator of sarcoplasmic reticular calcium uptake.
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Statistics
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PSSM-Id: 402246
Aligned: 29 rows
Threshold Bit Score: 22.4711
Created: 23-Mar-2022
Updated: 13-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDL22840      308 HRHqtQGHRKEE-DEDES 324
18_pfamImport   1 HRH--QGHGDEDgDEDES 16 
11_pfamImport   1 HRH--QGHRDE--EEDED 14 
14_pfamImport   1 HRH--QGHHDED-DDDED 15 
4_pfamImport    1 HRH--QGHEEED-DEDED 15 
5_pfamImport    1 YRH--RGHEEDD-DEDED 15 
P16230        199 HRH--RGHGKED-EEDED 213 rabbit
15_pfamImport   1 HRH--RGHEHED-DGDDS 15 
12_pfamImport   1 HRH--QGHEEDD-DDDDD 15 
13_pfamImport   1 HRH--QSHEDD--NDDDD 14
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