Conserved Protein Domain Family
APP_amyloid

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pfam10515: APP_amyloid 
beta-amyloid precursor protein C-terminus
This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into amyloid deposits which are strongly implicated in the pathology of Alzheimer's disease plaque-formation. The domain is associated with family A4_EXTRA, pfam02177, further towards the N-terminus.
Statistics
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PSSM-Id: 402237
View PSSM: pfam10515
Aligned: 18 rows
Threshold Bit Score: 62.733
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009019810  537 IVVGVLIMRRRG---NGFYSNNGRMEGERaendalNVSP---EEQHVASMQVNGYENPTYKYFE 594  Helobdella robusta
XP_790315     713 LVIAVLIVRRKT---RRTPVNSGFTEIDP------NLTV---EQRHIVAMQQNGYENPTYKYFD 764  purple sea urchin
EEN69130      608 IIVALIVLRKKHapmRQPGVNHAVVEVDP------SMTP---EERHVSKMQQNGYENPTYKYFE 662  Florida lancelet
P05067        716 IVITLVMLKKK----QYTSIHHGVVEVDA------AVTP---EERHLSKMQQNGYENPTYKFFE 766  human
1_pfamImport    1 AVVSMILRNRR--------STPNVVRINE------NVDDltqDEKQLLQMQHNGYENPTYKYLE 50  
ELW64527     1129 IVVSLVMLRKR----QYGTISHGVVEVDP------MLTP---EERHLNKMQNHGYENPTYKYLE 1179 Chinese tree shrew
XP_010737453  659 MVISLLLVRRK----PYGTISHGIVEVDP------MLTP---EERQLNKMQNHGYENPTYKFFE 709  large yellow croaker
XP_008986018  598 IVLSMLLLRRKK---PYGTISHGVVEVDP------MLTL---EEQQLRELQRHGYENPTYRFLE 649  white-tufted-ear marmoset
XP_007660237  310 VVLSLLLVRRRR---PYGAISHGVVEVDP------ILNL---EEPKPSALQPHGYENPTYRCLE 361  platypus
ESO01307      847 IIAGVMIMRRRA---AVSKQQHKILPTEPvig-dlVTSP---EESHVMNMQVNGYENPTYKYFE 903  Helobdella robusta
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