Conserved Protein Domain Family
Borealin

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pfam10512: Borealin 
Cell division cycle-associated protein 8
The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.
Statistics
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PSSM-Id: 402234
View PSSM: pfam10512
Aligned: 35 rows
Threshold Bit Score: 81.636
Threshold Setting Gi: 123885919
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFA07677            102 RQSRTKNRVPKtTRIsrsqslrtknvtevyktpAQRvp------anSYGTVTPKVKPNTPQVLLRRPKQGEVALSLQGSP 175 red flou...
6_pfamImport          1 -ASRAKLRTPMpAPRpra-------------tsADNd--------kHCEPKTPPRSPSSPATWLRWPKPGEKIISVTGTP 58 
WGS:AAPP:GF22049-PA  95 sigRLRLRTPRtQSQrdq------------aqsVDR------------MKTRSRTMKDISMTFQRWPRPGERVLSTSGSP 150 Drosophi...
XP_002029193         99 stARGRSRTPQtSLLprsl-----------iqsMDR----------GNFNRGRTPQKVPPMPFLRFPRAGELVLSSGGSP 157 Drosophi...
WGS:AAQB:GK15062-PA 202 RVSRNKMRTPM-ATRpka-------------fsADRntpmgkkmsrNSSPSTPPVA------FLRYPKPGEMALSKFGSP 261 Drosophi...
WGS:AAQB:GK15971-PA 138 hvARQKTRTPM-ASKlks-------------lsADR----------NDSPTTSPLA------FLRYPKPGEIALSKFGSP 187 Drosophi...
Q9VLD6              187 RNSRSKLRTPM-ASRaka-------------fsADRtplkq-kqmrSGSPTTPPMA------FLRYPKPGEVALSKYGSP 245 fruit fly
XP_001993103         57 RISRSKMRTPM-TARpka-------------fsADRtprnl-pkqrSTSPSTPPMA------FLRWPKPGEVALSKYGSP 115 Drosophi...
ETN66209            209 RLSRLKMRTPM-QETtkrar--------gqavsTDR----------GISQITLKVNLNTPITFLRHPRVGESVFSQSGSP 269 Anophele...
Q7QHK0              203 RTSRSKLKSSLaTNRpka-------------isADR----------GYGVITPKVQPYAALAMIRHAKQGESVFSLTGSP 259 Anophele...
EFA07677            176 LLTGnVVTDNVANINIPLEDGrLFSIQPQRG----LRvsqIPELDLETKRQLETLRDNLNKVCS 235 red flour beetle
6_pfamImport         59 LVSH-TAPEKFANVNIPVGDG-VLSLRPKRLe--dIDrsiVQKICPETMKQIKLLQSNLNRIME 118
WGS:AAPP:GF22049-PA 151 LAVQ-AHAELHADVHIPTRKG-VITVKPHKIk--nIErevLMEMDQNTLNQVKTLNDNLEMIVD 210 Drosophila ananassae
XP_002029193        158 LAVQtDRREDCADVHIPTKKG-VFMVKPLKMk--qVNrevLMQLDANVLNQVKTLKSNLEVIVD 218 Drosophila persimilis
WGS:AAQB:GK15062-PA 262 MVVQ-AMPDKFANVNIPIRNG-VLSLRPKRLaadeVEtdlLQALDEDTLNQIKTLHANLQVIVN 323 Drosophila willistoni
WGS:AAQB:GK15971-PA 188 ILTQ-VMTDSFANVNIPIQDG-VLCLTSKKLvegeVNkdlLKSLDENKLKEIKVLHANLQKIVN 249 Drosophila willistoni
Q9VLD6              246 MVAQ-VMPDKFANVNIPIRNG-VLSLRPKKLdadeVEsnlLENLDEDTLNQIKTLHENLQMIVN 307 fruit fly
XP_001993103        116 IVAQ-VMPDKFANCNIPIRNG-VLSLRPKKLd--eVKsdlVEHLDSDTLSQIKTLHENLQMIMN 175 Drosophila grimshawi
ETN66209            270 VVNA-TAYRQTRHINIPVPNG-MLALQSDELhd-eMVpemMPHLDSDTMDYLKG-RSRLQMvay 329 Anopheles darlingi
Q7QHK0              260 VVTA-NMLESSANVNIPVSNG-MIAIRPTELd--vIDeslIRKIDPNVLMELKQLQTNLDKIMS 319 Anopheles gambiae str. PEST
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