Conserved Protein Domain Family

pfam10511: Cementoin 
Trappin protein transglutaminase binding domain
Trappin-2, itself a protease inhibitor, has this unique N-terminal domain that enables it to become cross-linked to extracellular matrix proteins by transglutaminase. This domain contains several repeated motifs with the the consensus sequence Gly-Gln-Asp-Pro-Val-Lys, and these together can anchor the whole molecule to extracellular matrix proteins, such as laminin, fibronectin, beta-crystallin, collagen IV, fibrinogen, and elastin, by transglutaminase-catalyzed cross-links. The whole domain is rich in glutamine and lysine, thus allowing and transglutaminase(s) to catalyze the formation of an intermolecular epsilon-(gamma-glutamyl)lysine isopeptide bond. Cementoin is associated with the WAP family, pfam00095, at the C-terminus.
PSSM-Id: 371104
View PSSM: pfam10511
Aligned: 7 rows
Threshold Bit Score: 25.7048
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
AAI26811      68 GQGPVKGQGPVKGQDPV 84  cattle
XP_004062270  55 GQDKVKAQEPIKGPVST 71  western lowland gorilla
XP_005569179  55 GQDRVKGQGPVKGPVST 71  crab-eating macaque
XP_005673022  68 sQDPVKAQLPDKGQDLV 84  pig
1_pfamImport   1 GQDTVKGRVPFNGQDPV 17 
ABO52943      31 GQGTGKGRVPLKGQDPL 47  small-eared galago
P16225       100 GQDVVKGHEPVEGQDPV 116 pig
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