Conserved Protein Domain Family
NARG2_C

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pfam10505: NARG2_C 
NMDA receptor-regulated gene protein 2 C-terminus
The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.
Statistics
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PSSM-Id: 402229
View PSSM: pfam10505
Aligned: 24 rows
Threshold Bit Score: 225.636
Threshold Setting Gi: 193914862
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ETN66051            406 ALDKRQHeNRFYQLWKLTdeq---------sdeEQAVLIDFRQDFYQTLRK-TRLFMNLSVKLEHQPEFGAEQMTKAELL 475 Anophele...
XP_001954923        386 GIVDSNS-NCALVSWILKsq-----------dhNFQMFSTLSIPAVRDSYGkKLLGCHLI-KLENKPDCGCEIMTKYELL 452 Drosophi...
Q8IGQ6              106 DIEDGNC-NSALVSWTLRckgeg------ddcnDFQIFSTLSIPAVKDSSGkEPLGCHFI-KLENKPDCGCEIMSKYELI 177 fruit fly
EDV91144            384 PIKQARS-NGALVSWRLQtde---------kddALLIYSSLAIAAVRDTLGeHPLGCHLI-KLENKPDCGCEIMTKYELI 452 Drosophi...
WGS:AANI:GJ23962-PA 386 pmPEAKS-NSALVSWRLRagead-----teaepALLMYSSLPIAAVRDAAAnQMLGCHLI-KLENKPDCGCEIMTKYELL 458 Drosophi...
EDS41823            378 pSEPVQK-NVSLQLWNLQdg-----------deQYRFLVRTRTDCYESLRK-VKFYINISIKLEYQTEFGAEQMTKSELI 444 southern...
Q16PH7              388 ELKPYPNrNSCLQLWTLQeg-----------ddQYRFLIRFRMDCYESLRK-IKFYINISVKLEYQTEFGAEQMTKSELI 455 yellow f...
XP_008180842        235 SVQDDYN-NYNYDKWMLKvsnvn------gvdkSFNLLVRNKPHGIQQQIKpQNTPVVIIPKVEYQPEFGFEKVSEEQLV 307 pea aphid
EFN68808            340 etnnIKT-NVMYKLFTIGpteslnqelgkhdvkEYQMLVRTKTDGTEVLPN-KTQHVILTPKMEHQLGLGAEAVTFEELS 417 Florida ...
EFX71206            523 YIQPKRNeNLTYRTWDLKvn-----------ekSVRLLVRSSVDTAIVKPDdSLKTFLMVPKTEYQPWYGAECYSPREIN 591 common w...
ETN66051            476 HEWARQLLR-PNSKTLRIRLDPVTHRMISSHYLELRDIEEELLrlyGV--KPRHLITSMWGTLRRL--QLFPVGSYLLHR 550 Anophele...
XP_001954923        453 KAWLQIKLL-QAESGHCTRISLRDFDPVLEEKLTLASLEQQLHdyyNT--SMPQLLSNLFEFLKIF--HTVPVGDYLLRY 527 Drosophi...
Q8IGQ6              178 SAWVQLKLM-RAEMGHCTRISLRDFEPMLEEKLTLISLEQQLHdyyNT--SMPQLLSNLCEFLKLL--DTVPAGDYLLRY 252 fruit fly
EDV91144            453 SAWLQLKLL-QANVGHCSRISLRDFAPLLEQQLKLEALEEQLYeyyHT--SMPQQLCQLHEFLKLL--RTVAPGEYLLRY 527 Drosophi...
WGS:AANI:GJ23962-PA 459 SAWLQLKLL-QTDIGHCSRISLQDLAPLLEEPLTLGALEQQLHeyyHI--SMPQQLSQLREFLKLL--RSVTPGRYLLRY 533 Drosophi...
EDS41823            445 REWTRQRLR-PNSRTLRLRINASNHIILSHHYLELKDIEEELKrlyDI--EPQNLLTNLWQTLRLI--MQFPPGEHLLQH 519 southern...
Q16PH7              456 HEWARQYLR-PNSKTLRLRINAVTHVIISHHYLELKDIEEELKrsyDI--EPANLFTNLWQTLKIL--LNFPPGDHILQH 530 yellow f...
XP_008180842        308 EYWLDTSFRcPKTKLAL--VSVQHDMDLMQVKWTIEEVESLSS---NG--KDQMYLQRLYLTLEKL--TQLGKGEYVLLH 378 pea aphid
EFN68808            418 HQWASLIFR-PGTILGRVRIEVDSSEIIQIEKHTTASLSNEMRrlyNT--KIEDSLSILHNIIEGL--SSLTPGQYIMRH 492 Florida ...
EFX71206            592 EQWMDLYLR-PECNLLRMRLDAYSGHLLVHEQKDVACLEAENSfqyGTqnKPANCLKNVWAVLSSLcdLNLSPGKFLLRH 670 common w...
ETN66051            551 DERTVqGWSVYTEVgrergqqLNPNAVVYDLRTRLHAIEYDLPPLEq----YDWIPIDKCFITQVHREGSILPCSFPH 624 Anopheles ...
XP_001954923        528 SPK-------YKDKfllctttKQASTQSFQLHQVLKD--AVPSDQNfl-sqSSYLPISATLCGRMHEELQLVPCSFPA 595 Drosophila...
Q8IGQ6              253 SPK-------YKDKfllcivtKEATPQSFQLHQLLTE--SIPSDQAfl-tqSSYLPISPTLCGRLHEELHLLPCAFPA 320 fruit fly
EDV91144            528 TTK-------YKDKfllcrpsLEATAQSFQLHDLLMS--KPPTDINfltqsNSYLPISTKLCSRLHEQLQLLPCAFPA 596 Drosophila...
WGS:AANI:GJ23962-PA 534 TAK-------YKDKfllcqptPEPTPNSFKLYDLLAG--TSPNDINfltqaASYLPISPKLCSRLHEQLQLLPCSFPV 602 Drosophila...
EDS41823            520 DTKNPeTVMILSQS---------STTFTLDLHALYSNVEYERCALEe----YDWVPIDATVITKLHREHTLLPGTFPH 584 southern h...
Q16PH7              531 DMKNKdIVNVLSNDn-----sPNPTSSSINLVDQYSNVEYDRPAVEs----YDWIPIDKSVITQMHRENTLLPCTFPH 599 yellow fev...
XP_008180842        379 NPKKPfHVDVYQSS----------VYGGFNLLNMYFVLQQTEVSDS-----LVWNPIDREILCPIHNYFKVAPCMFrp 441 pea aphid
EFN68808            493 VPQRGpFAYIYKQV-------EEPGKNVFDLHTVCQSAMLQTVPKT------PWPLIDTMLTTPAIRQFKKMPAMFnp 557 Florida ca...
EFX71206            671 GFHDGiCIQVWEST--------DKESSSLDLHQIYAEIDTTANAVRdv--gENWVALDPYAVLPIQRALFRPPLTFep 738 common wat...
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