Conserved Protein Domain Family
Syntaxin-18_N

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pfam10496: Syntaxin-18_N 
SNARE-complex protein Syntaxin-18 N-terminus
This is the conserved N-terminal of Syntaxin-18. Syntaxin-18 is found in the SNARE complex of the endoplasmic reticulum and functions in the trafficking between the ER intermediate compartment and the cis-Golgi vesicle. In particular, the N-terminal region is important for the formation of ER aggregates. More specifically, syntaxin-18 is involved in endoplasmic reticulum-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER with the plasma or phagosomal membranes.
Statistics
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PSSM-Id: 402222
View PSSM: pfam10496
Aligned: 71 rows
Threshold Bit Score: 56.6167
Threshold Setting Gi: 384495999
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003224195     4 DITLLFKASVKTVKtrnkalGvplGGgggsdssrddA----LLLLKRSRPRSDFSSRAREVVNNIGKLKDFLLQHRKDYI 79  green anole
CCD22479         3 DLTPVFQKYINIIK------S---EYpervhklpadAhskqLKSKSALQLKDTFIKECYDLLNCLIELKKILSSIESQYK 73  Naumovozyma d...
XP_003679584     3 NLTSVFQEYVNIIegdg---------------qqenNartdAKETKKYILKDSFIKECQQLLRLLIELRKVLKSVEPKYM 67  Torulaspora d...
Q6FMT0           3 NLTPLFRQYVSIIadest--------------glqeAqsetKSSLNEIVTRDSFLKECRSLAKFLFELNTVLKSVCEEYM 68  [Candida] gla...
P41834           4 DLTPIFRKYVAVIDd----aRn-eQNgiddh-verkQedfgNSNETCEMFRDSFIKECARLLKFLVELNKVIKQIEKNYL 77  Saccharomyces...
EJT42306         3 NLTSIFQKYVAVIDe----tRk-eQGernehikeegQedlgNSDEIREIVNDSFIKECAKLLKFLIELNRVIKEIEKNYM 77  Saccharomyces...
Q759Q3           3 DLTQLFRKYVAIIEe-----Ar--NDpdgeadqrskGvtqsNGSMEKFRIKDTFVKECSELARHILELRKVLTSLEGPYL 75  Eremothecium ...
XP_002554962     3 DLTPLFKKYVTVFsedek-------------rsidrRaqdnRKPSKKYMVNDTFVKECSELLRHILELQKVVFSLKPQYE 69  Lachancea the...
CCH58713         3 DITNVFRKYVSIIE------E---NRrtptltpddiKsasqTQTLIHESLNDSFMFECKELFKTIIDLRKILISIEPRYL 73  Tetrapisispor...
ybcl:Ecym_4041   3 NLTPLFRKYVEVIG------E---ARegdvlvvsevEvkkrKQWRTKFTVSDTFLEECSDLLKHIIELRKVILSLQVEYL 73  Eremothecium ...
XP_003224195    80 NTYShamsefvrMTDTERDQI 100 green anole
CCD22479        74 SDVD--------MTELEKDDF 86  Naumovozyma dairenensis CBS 421
XP_003679584    68 SERD--------MTESDKDDF 80  Torulaspora delbrueckii
Q6FMT0          69 NDFS--------MTEAEKDNF 81  [Candida] glabrata
P41834          78 DDFN--------MSDAEKDEF 90  Saccharomyces cerevisiae S288C
EJT42306        78 DDLN--------MTDAEKDEF 90  Saccharomyces kudriavzevii IFO 1802
Q759Q3          76 SEGE--------MSEREKDDF 88  Eremothecium gossypii
XP_002554962    70 SDSE--------LSEREKDDF 82  Lachancea thermotolerans CBS 6340
CCH58713        74 DDSD--------LTEEEKDDm 86  Tetrapisispora blattae CBS 6284
ybcl:Ecym_4041  74 GEVD--------MSEQEKNDf 86  Eremothecium cymbalariae DBVPG#7215
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