Conserved Protein Domain Family
Stk19

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pfam10494: Stk19 
Serine-threonine protein kinase 19
This serine-threonine protein kinase number 19 is expressed from the MHC and predominantly in the nucleus. Protein kinases are involved in signal transduction pathways and play fundamental roles in the regulation of cell functions. This is a novel Ser/Thr protein kinase, that has Mn2+-dependent protein kinase activity that phosphorylates alpha -casein at Ser/Thr residues and histone at Ser residues. It can be covalently modified by the reactive ATP analogue 5'-p-fluorosulfonylbenzoyladenosine in the absence of ATP, and this modification is prevented in the presence of 1 mM ATP, indicating that the kinase domain of is capable of binding ATP.
Statistics
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PSSM-Id: 402220
View PSSM: pfam10494
Aligned: 50 rows
Threshold Bit Score: 135.46
Threshold Setting Gi: 74856120
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EON64937      78 RDRMFSdvperGSGMNSTRTAEVLNYRLN-LP-PIVTVAHIHSFT-N-SPTSIDREIAELIRSGKIRKLVIPGRNAGRAa 153 Coniosporium ap...
EMG47184     110 EERIFS-----LKRLSSDAKVAILKFRKG-FPsGLVTVTQLYSIFlNqNNTFVDKSVELGVRQGKLRKFVINNASPVISr 183 Candida maltosa...
Q6BK80       122 EDLLFL-----LPGLSMKVKAEVIKYRTNqLPhGLITINQLYSIYeQqGNTFVDRNLEMRIREGKLRKFVITNASPIILr 196 Debaryomyces ha...
EDK36362     111 DQLLFS-----LPGLSMEVKADILRYRKShLPiGLLTLNQLYSIYdRqGPTYVDRNLELRLREGKVRKFVITNAAPVVSr 185 Meyerozyma guil...
CCE72937     119 EDLLFS-----IKGIALKTKAEIVKYRKSqLPyGMVTINQLYSIYeHqGQTFVDKNLELNIRKGKLKKFIITNAAPVIQr 193 Millerozyma far...
XP_006685681 121 EHLVFQ-----LKGLAMSTKAEIMKYRTThIPqGLVTTNQLYSIFdKeGNTFVDRNIELSIRKGQIRKFVITNAAPIIQt 195 Yamadazyma tenu...
ABN67956     127 EKLVFS-----LKGLSAKVKAEIMKYRQNqLPkGIVTTAQLYSIYeSqGNTFVDRNLELNIRNGNLKKFVITNASPVISr 201 Scheffersomyces...
EGW32948     106 EERIFS-----LKGLSSTVKAEIVKYRNQtH--DLITTTQLYSVCsHlGNTFVDRKLELLIRQGKVRKFVISNASPVISr 178 Spathaspora pas...
CCE44862     116 EEKVFQ-----IKGLSSTLKAELIRYRHS-LPqGLVAITQLYAIFhNeGPTFVDKSLELNIRKGILRKFIITNASPVISr 189 Candida parapsi...
XP_001525879 139 EEVIFQ-----IKGLSLTSKAELVKFRLS-FPsGIVTINQLYSIFsAqGNTFVDKQVELNVRQGLLRKFVLNNASPVILr 212 Lodderomyces el...
EON64937     154 grdAVG-----------DCLVLFSDWERLVRSHPDLTDGLK--------------------EKYVTLLRATQTSSIAssA 202 Coniosporium ap...
EMG47184     184 ssnKFQsgkvtygfenvDILVETETYFEMIKSAINASQEDltatpeqr------klalsslTNFQNYLNKSPSALYVtg- 256 Candida maltosa...
Q6BK80       197 spqKFQhgkvtygyenvEVIVKSENYLNNIKSQINILEKEMnvqdilindksnkaslceclQKFLKFVINHPTALFI--N 274 Debaryomyces ha...
EDK36362     186 tqnKYQgrvty-ghenvEVIVKSEQYYDLIEREVDAIDSEAgkcnsmqese-rlklqsttlKKYLQFLKGNPSALYIhs- 262 Meyerozyma guil...
CCE72937     194 sqqVFQhgkvtygyenvELVVKTDTYLDRIKHQIETYSEASknditppsereialsyteslQKFLSFVVANPTSLFV--T 271 Millerozyma far...
XP_006685681 196 sndQARngkitygyenvEVLVKTGVFYSKIQETLSKLTDSFqik---------------vlQKFEKFTKENPTTLFI--S 258 Yamadazyma tenu...
ABN67956     202 tkqKYQhgkvtygfenvEVVVKTESYFKLICEEIERLEKELvdssmatserikkdrqltsiKKFFEYLKSNPASIFVth- 280 Scheffersomyces...
EGW32948     179 nvqKFQlgkvsygfenvEVVVKTDNYYKLIEGAIQASPKEea------------------lTKFYQYVKGNPTSLFI--N 238 Spathaspora pas...
CCE44862     190 shnKFQvnkvtygfediEVIAKVDYFHKLIKKVMSGLDDKSssk--------------qalVKFNELISLHPTEMFIst- 254 Candida parapsi...
XP_001525879 213 sinRLQmrkvtygyenvELLVKTEDYYKNLINIVESTDKENeklr-------------ltmSKFLNLAKSSPLQMFIst- 278 Lodderomyces el...
EON64937     203 ----LTH-SEAATLTSAGFLISTtasahsstadfflrpsvassgtlsslasagsraaagtleavggvnalhnvggsgggt 277 Coniosporium ap...
EMG47184     257 --dtFANqDEVSYLVKSGFLTLSsn------------------------------------------------------- 279 Candida maltosa...
Q6BK80       275 nnqgMDN-QELSKLVSLGYITLTsn------------------------------------------------------- 298 Debaryomyces ha...
EDK36362     263 --ddFAS-AELSTLVSLGYVTLTsn------------------------------------------------------- 284 Meyerozyma guil...
CCE72937     272 vndvLQQ-KHLSDLVALGYMTLTsn------------------------------------------------------- 295 Millerozyma far...
XP_006685681 259 tedsFLE-SELTTLVELGFITLTsn------------------------------------------------------- 282 Yamadazyma tenu...
ABN67956     281 --edFDN-EQLSSLVSFGLVTLTsn------------------------------------------------------- 302 Scheffersomyces...
EGW32948     239 isetFTN-EDLSVLVNHGLVTLTsn------------------------------------------------------- 262 Spathaspora pas...
CCE44862     255 --ldFTN-EEVSNLVQLGFITLTsn------------------------------------------------------- 276 Candida parapsi...
XP_001525879 279 --slFDD-YEVSMLIQMGYLTLTt-------------------------------------------------------- 299 Lodderomyces el...
EON64937     278 aisggarAAAASGAQYNFSLPNTGPYLRLLTTARSHLVTLLGKSsRYREAPVSLLRDRWDG---GVADDSTATQAKKvrg 354 Coniosporium ap...
EMG47184     280 ------hLNEIEVSQYAISYPSCGTYLKMINAGRTWLVKLLNKG-KFKELLEDQIQSKWEGf--TPQGNSKMNNFRA--- 347 Candida maltosa...
Q6BK80       299 ------hLNEIESHQYSISYPNCGTYLKLINAGRSWLVKSLNKC-KYKELLEEHLFNRWEGlntSFNGTSKMNNFRS--- 368 Debaryomyces ha...
EDK36362     285 ------hLNEIESHQYSVAYPNCGTFLKLINSGRAWLVKTLNKS-KHKELLEENLFQKWEGy--STNGTPKMTNFRK--- 352 Meyerozyma guil...
CCE72937     296 ------hMNEIES-QYSISFPNCGTYLKLVNSGRVWLVKTLNKT-KHKELLEEDLFNRWEGqpnSFTAAPKYTNFRP--- 364 Millerozyma far...
XP_006685681 283 ------hKNEIESQQYALSFPNCGTYLKLVNNGRSWLVKTLNKC-KFHELLESELFNRWEGi--DLNDNSKMSNFRK--- 350 Yamadazyma tenu...
ABN67956     303 ------hLNEIESHQYSISYPACGTFLKLINAGRVWLVKALSKG-KYNENLEDQLFKKWEGt--TLNGDSKMNNFRP--- 370 Scheffersomyces...
EGW32948     263 ------hLNQIESHHYSIAYPNCGTFLKLINQGRVWLVKSLTKA-KHKEMVEDQLFKRWEGv--NLQGESKMNNFRK--- 330 Spathaspora pas...
CCE44862     277 ------hFNEIE-HKYSISYPGCGTYLKLVNEGRTWLVKSLNRN-KHKEALEEELFRKWSGm--NPEGDPKLNNFRK--- 343 Candida parapsi...
XP_001525879 300 ------nFSSSEEAQLEISYPGCGRFLRLINEGRMWLVGTLNRN-THKEMLEDELFRKWMGv--SLEGDLKLNNFKK--- 367 Lodderomyces el...
EON64937     355 efvgvlpgrtkkwrTFWGLRFEWVLEEAVGMGLVEAFQTgSVGLGVRV 402 Coniosporium apollinis CBS 100218
EMG47184     348 --------------PFFGYDLNWVLADALGAGVIEVFNT-PVGRGWRL 380 Candida maltosa Xu316
Q6BK80       369 --------------PFYGYDLFWILADALGAGVIEVFNT-PVGRGWRL 401 Debaryomyces hansenii
EDK36362     353 --------------PFYGYDLFWILADALGAGVIEVFNT-PVGRGWKL 385 Meyerozyma guilliermondii ATCC 6260
CCE72937     365 --------------PFYGYDLIWILADALGAGVIEVFNT-PVGRGWHl 397 Millerozyma farinosa CBS 7064
XP_006685681 351 --------------PFYGFDLNWILADALGAGIIEVFNT-PVGRGWKL 383 Yamadazyma tenuis ATCC 10573
ABN67956     371 --------------PFYGYDLNWILADSLGAGVIEVFNT-PVGRGWRL 403 Scheffersomyces stipitis CBS 6054
EGW32948     331 --------------PFYGYDLNWIIADALGSGVIEVFNT-PVGRGYRL 363 Spathaspora passalidarum NRRL Y-27907
CCE44862     344 --------------PFYGYDLHWVLADGLGSGIVEVFNT-PVGRGWRL 376 Candida parapsilosis
XP_001525879 368 --------------PFYGYDLHWVLADAFGGGIVEVFNT-PVGRGWRL 400 Lodderomyces elongisporus NRRL YB-4239
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