Conserved Protein Domain Family
PP1c_bdg

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pfam10488: PP1c_bdg 
Phosphatase-1 catalytic subunit binding region
This conserved C-terminus appears to be a protein phosphatase-1 catalytic subunit (PP1C) binding region, which may in some circumstances also be retroviral in origin since it is found in both herpes simplex virus and in mouse and man. This domain is found in Gadd-34 apoptosis-associated proteins as well as the constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, regulatory (inhibitor) subunit 15b, otherwise known as CReP. Diverse stressful conditions are associated with phosphorylation of the {alpha} subunit of eukaryotic translation initiation factor 2 (eIF2{alpha}) on serine 51. This signaling event, which is conserved from yeast to mammals, negatively regulates the guanine nucleotide exchange factor, eIF2-B and inhibits the recycling of eIF2 to its active GTP bound form. In mammalian cells eIF2{alpha} phosphorylation emerges as an important event in stress signaling that impacts on gene expression at both the translational and transcriptional levels.
Statistics
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PSSM-Id: 402216
View PSSM: pfam10488
Aligned: 6 rows
Threshold Bit Score: 289.609
Threshold Setting Gi: 123888194
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008266758 393 LPPSARPACSnklidyilgGSSSDLETS---------SDSEgEDWDEEaEDDGFdsDSSLSDSDPepdp-eglhLWNSFS 462 rabbit
Q1L914       148 KPISDPGSCA---------LSKENVQSSrqvqsishfSDSE-FSWGST-DSSCF--EGEREESDK---------LWDLLT 205 zebrafish
XP_016285583 613 LPIYARPACSnklidyilgGASSDQETS---------TESEgEDWDEEvEDDGFdsDGSLSESDSgkrhsegllLWNSFY 683 gray short-tail...
Q5SWA1       413 LPISARPACSnklidyilgGASSDLETS---------SDPEgEDWDEEaEDDGFdsDSSLSDSDLeqdp-eglhLWNSFC 482 human
Q8BFW3       397 LPVSTRPVCSnklidyilgGAPSDLEAS---------SDSEsEDWGEEpEDDGFdsDGSLSESDVeqds-eglhLWNSFH 466 house mouse
XP_003474851 405 LPLSARPACGnklidyilgGASSDLETS---------SDSEgEGWDEEeEDDGFdsDGPLSESDLeqds-eelhLWNSFY 474 domestic guinea...
XP_008266758 463 -SVDPYSLQNFTAAIQTAARAAPAApsdsepdpadqsdrASSPQLGGPPGTPDWHSGeeEEEDWG-SSADEAESlKLWNS 540 rabbit
Q1L914       206 kSTDPYHPLHFTACLSTVVTEKPKP--------------EVVSKAESPIASQSTVST--SSDSSKpGSEDEEEE-ALWRS 268 zebrafish
XP_016285583 684 -SIDPYNPQNFTATIQTAATTISGDhynseddspeksdgED-SWTESPPRSPDHCSG--EEDDWE-SSADEAENlKLWNS 758 gray short-tail...
Q5SWA1       483 -SVDPYNPQNFTATIQTAARIVPEEpsdsekdlsgksdlENSSQSGSLPETPEHSSG--EEDDWE-SSADEAESlKLWNS 558 human
Q8BFW3       467 -SVDPYNPQNFTATIQTAARIAPRDpsdsgtswsgscgvGS-CQEGPLPETPDHSSG--EEDDWE-PSADEAENlKLWNS 541 house mouse
XP_003474851 475 -SVDPYNPQNFTATIQTAPKIVPGEpsdsgkelsdksdlEN-SQADTFPETPDSSSE--DEDDWE-SSADEAESlKLWNS 549 domestic guinea...
XP_008266758 541 FCHSDDPYNLLNFRAPFQTSgkqgkgcqdlksppeSMVAIAEGR-----ALLSCGVRQAGSPGSECPGWGQRGS------ 609 rabbit
Q1L914       269 LSQNDDPYHPLNFRAPLQSS---------------SVTPVPSKHdspsnNMQNTPIRPLKSSRRSKPALLPNKVarhccr 333 zebrafish
XP_016285583 759 FSNSDDPYNPFNFKAPFQTAgkkgkdecdsnirteS-SAISRGH-----ALLSCKVQLLGSPETGITDFVQYGI------ 826 gray short-tail...
Q5SWA1       559 FCNSDDPYNPLNFKAPFQTSgenekgcrdsktpseSIVAISECH-----TLLSCKVQLLGSQESECPDSVQRDV------ 627 human
Q8BFW3       542 FCHSEDPYNLLNFKAPFQPSgknwkgrqdskasseATVAFSGHH-----TLLSCKAQLLESQEDNCPGCGLGEA------ 610 house mouse
XP_003474851 550 FCNSDDPYNLLNFTAPFQTSgkdskdcldskrlpeSLVAISECH-----SLLSYKGQLLGHQEDECPNLLQREF------ 618 domestic guinea...
XP_008266758 610 --------------------LSGERHAHSKRKKVTF-----LEEVTEYYISGDEDRKGPWEEFARDGCRFQKRIQETEDA 664 rabbit
Q1L914       334 klsvetlsvvpwkrhvgvtsVQGNQKRSPKLKKVKFspvvqVHKMRAWSFALQASRKGPWEELARDRDRFRKRIGDTEKA 413 zebrafish
XP_016285583 827 --------------------LSGEKHTATRRKKVTF-----LEEVTEYYISSDEDRKGPWEELARDGCRFQKRIQETEDA 881 gray short-tail...
Q5SWA1       628 --------------------LSGGRHTHVKRKKVTF-----LEEVTEYYISGDEDRKGPWEEFARDGCRFQKRIQETEDA 682 human
Q8BFW3       611 --------------------LAGERYTHIKRKKVTF-----LEEVTEYYISGDEDRKGPWEEFARDGCRFQKRIQETEVA 665 house mouse
XP_003474851 619 --------------------VE--KHTSIKRKKVTF-----VEEVTEYYISGDEDRKGPWEEFARDACRFRKRIQETEDA 671 domestic guinea...
XP_008266758 665 IGYCLTLEHRQRVFNRL 681 rabbit
Q1L914       414 IGYCFSLSNREKMRAYR 430 zebrafish
XP_016285583 882 IGYCLTFEHRQKIFNKl 898 gray short-tailed opossum
Q5SWA1       683 IGYCLTFEHRERMFNRL 699 human
Q8BFW3       666 IGYCLAFEHREKMFNRL 682 house mouse
XP_003474851 672 IGYCLTFEYRERIFNRL 688 domestic guinea pig
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