3J4Q


Conserved Protein Domain Family
AKAP7_RIRII_bdg

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pfam10470: AKAP7_RIRII_bdg 
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PKA-RI-RII subunit binding domain of A-kinase anchor protein
AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.
Statistics
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PSSM-Id: 371072
View PSSM: pfam10470
Aligned: 8 rows
Threshold Bit Score: 84.2064
Threshold Setting Gi: 699608388
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3J4Q_A       295 EPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGE-GNSVKAEEGDRNg-DGSDN 350
XP_003215759 257 EPDDAELLSLSKRLVENAVLKAVQQYLEETQNKNRQLDfGAPVKTEEPTLG--NNMEN 312 green anole
XP_010705717   9 EPDDAELVSLSKRLVENAVLKAVQQYLEETQNKARQTD-GSPLKAEEAASGtkNESNN 65  turkey
XP_008993323  23 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGE-GSSVKTEAADRNg-NDNEN 78  white-tufted-ear marmoset
XP_005615711 268 EPDDAELLRLSKRLVENAVLKAVQQYLEETQSRGKPAD-GSSGKARAADRGgaDGDQs 324 dog
O55074        23 EPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGE-GNSTKAEEGDRNg-DGSDN 78  house mouse
XP_009872654   6 EPDDAELVSLSKRLVENAVLKAVQQYLEETQNKTRQTD-GSPVKTEEAASGskNESDN 62  bar-tailed trogon
XP_020842720  23 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKTRQVD-GSPVKTEEPVHSdrNDSDN 79  koala
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