Conserved Protein Domain Family
MENTAL

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pfam10457: MENTAL 
Cholesterol-capturing domain
Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain pfam01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localization of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.
Statistics
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PSSM-Id: 402197
View PSSM: pfam10457
Aligned: 27 rows
Threshold Bit Score: 190.159
Threshold Setting Gi: 780149659
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023205342  39 SDVRRTFCLFVTFDLLFITLLWIIELNVTG--PILDNLADQVI-----RYK---FKSSFFDIVLLALFRFLCLQIGYAAF 108 southern platyfish
EKC32179      70 SSVRRTFCLIALFDLCFCFILWVIYTQLTGseTVWEAFEQQVA-----NYQ---FQTSLFDTVMVAALRFILIELGYALF 141 Pacific oyster
XP_001635683  31 SPSRRMFCLLTAFDFLFTLVAWVIYSHALKe-GLWLSFDTEVA-----HYK---FKSSLFDLLLLSLWRMVVLLLAYALF 101 starlet sea ane...
XP_011681721  63 SAVRRVFCLLATFDLLLTAVLWFIFIQLVGl-GVKDGFSCQIQ-----KYD---FHYSLFDIVAMAFFRFAVLLLAYALF 133 purple sea urchin
Q19819        18 SKDRKRFIVITFFDTSITILLWLLCTVTRDd-DWDKVFFNEIN-----IFNpkfIRISLFDIVLLAVLRMLILGVVYGIC 91  Caenorhabditis ...
XP_002005254  56 SVVRRFFCLFVTFDLLFVSLLWLICIVIGGd-NIFQAFQKQVM-----HYT---IYTSLFDVVATALCRFIVLIFFYALL 126 Drosophila moja...
EEB14474      69 SSIRRFFCCFVLFDLLLISLIWLICITIIDsnNIIKVIKMQIL-----NYN---ISTSLFDLVGAAIIRFIILLLFNGIL 140 human body louse
Q16UM5        83 SVVRRFFCLFVTFDVVFISLLWIICVMITGd-NIVHALQTQVV-----HYT---IYTSLFDVVVSALLRFLFLILFYGLC 153 yellow fever mo...
ETN59759      77 SVVRRFFCLFVTFDLVFISLLWIICVVIKGq-NVLSALEAQVV-----HYT---VQSSLFDVVAVAFIRFIVLILCYGLL 147 Anopheles darlingi
XP_002130557  87 SDPRRTFCLFVTFDFLITVLLWLTECGISSt-NGKDPFFTILNfqmshFYK---PSESLFDVTMLAAVRFLFLVLSYAIL 162 vase tunicate
XP_023205342 109 RLKHWWVVAISTLVTSVFLVVKVIVSELL---------------SKNAF--GYVLPITSFVVAWLETWFLDFKVLTQEAE 171 southern platyfish
EKC32179     142 RLNHWWLIAISTSLTCIFLITKVFLFEFShd-----------gkAENPL--SYILLLTSFILTWIETWFLDFKVLPTEKK 208 Pacific oyster
XP_001635683 102 VSRKWYTIAVVTTVSTAFVVVKVFFYNFDd-------------sKGHPM--DFVLVTMSLVLCWIETWVLDFKVIPSENE 166 starlet sea ane...
XP_011681721 134 KSKHWIFAAITTTATTGLIVAKIFLYSLTdtsgfpsgcapsnvsSNTFM--VIVMLLSSLLLAWLELWVLDFQVIPKEKK 211 purple sea urchin
Q19819        92 LVKQWYTVAFTTLASSAYILMKVLFYfn--------------hsSSAVP--PLLLIITSFTLCWSEFYLMPFQILPRERR 155 Caenorhabditis ...
XP_002005254 127 YINHWSIIALSTSSSCLFLITKVFFYDWVh-------------sKQQVF--DVILIITSFILAWGEAWFLDCRVIPQERH 191 Drosophila moja...
EEB14474     141 QLNTKFFIGLTTFATLLFLVFKVIYYSWSs-------------eGQPTF--AVIIILMSFIVAWLEAWFFDCRVIPQELF 205 human body louse
Q16UM5       154 HLNHWVVIALSTTGSCAFLIYKVFVYNWTa-------------tPQPVF--EVLLIVVSFVLAWGEAWFLDCRVIPQERY 218 yellow fever mo...
ETN59759     148 GISHWVVIALSTTSSCGLLICKVILYDWTa-------------tSQPVF--EVLLIVVSFVLAWSEAWFLDCRVIPQERY 212 Anopheles darlingi
XP_002130557 163 RIKHYWPVAVSTAVSDVLLILKIFGIFAMsk-----------qtSSLNLpmTIVVVLADFVLTWIEVWFVDFKVLPAEMK 231 vase tunicate
XP_023205342 172 NDRAYLAA------------------SNAD---------RASMLYSHP--------------VSDGQ------------- 197 southern platyfish
EKC32179     209 IL----LRgt--------------hgEANE---------RSGLLGRAEeggnr-----vvhdDDKDR------------- 243 Pacific oyster
XP_001635683 167 VEQRSNAGsl--------------etTAGE---------RRPLLGENYtgiyn----trtwlSEHAS------------- 206 starlet sea ane...
XP_011681721 212 LLEEALMAhs---------------lETDE---------RRPLLDNSIdrr--------ydlPGGQA------------- 246 purple sea urchin
Q19819       156 YARRELDGi------------------------------ENPEFSTDDearsnnrhrrgrrqQNSGNqseaptavpsrvs 205 Caenorhabditis ...
XP_002005254 192 ARR-YFAAa-----------------SSTD---------RAALTQPTIlter------erpaQSVTD------------- 225 Drosophila moja...
EEB14474     206 ALH-YVQTtg--------------rlSESLnnlmtdrdfRNPLLKSFRarfad-----feegASFKN------------- 252 human body louse
Q16UM5       219 ARN-YYVA-------------------AEA---------RTPLLAPFLsagl------sgrtESVGN------------- 250 yellow fever mo...
ETN59759     213 ISN-YLTAtg--------------ptSVDA---------NTPLLQPYMtia--------aggESVGN------------- 247 Anopheles darlingi
XP_002130557 232 LAQKTVRDflqqsyqstppqddgrrfV------------PRPSYGAT---------------SERAS------------- 271 vase tunicate
XP_023205342 198 ---FYSPPES 204 southern platyfish
EKC32179     244 ---YYSPAgs 250 Pacific oyster
XP_001635683 207 ---FYTPHGS 213 starlet sea anemone
XP_011681721 247 ---FYSPYDS 253 purple sea urchin
Q19819       206 sgvFIASDYD 215 Caenorhabditis elegans
XP_002005254 226 ---FYSPLDT 232 Drosophila mojavensis
EEB14474     253 ---YYSPLEs 259 human body louse
Q16UM5       251 ---YYSPYDS 257 yellow fever mosquito
ETN59759     248 ---FYSPFES 254 Anopheles darlingi
XP_002130557 272 ---FYSPAat 278 vase tunicate
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