5G06,3M7N


Conserved Protein Domain Family
EXOSC1

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pfam10447: EXOSC1 
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Exosome component EXOSC1/CSL4
This family of proteins are components of the exosome 3'->5' exoribonuclease complex. The exosome mediates degradation of unstable mRNAs that contain AU-rich elements (AREs) within their 3' untranslated regions.
Statistics
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PSSM-Id: 402191
View PSSM: pfam10447
Aligned: 11 rows
Threshold Bit Score: 84.8552
Threshold Setting Gi: 295322006
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5G06_I       132 LPKE--GDIVLTRVTRLSLQRANVEILAVEDK------PSPIDSGIGSNGSGIVAA---GGGSGAATFSVSQA------- 193 baker's yeast
EDO15415     122 LPKE--GDIVLAKVTRISLQRANLEILAVENQ------PVPIDSGVGSNGHGVVAA---GGGSGSSKFSVAQT------- 183 Vanderwaltozyma...
Q6FP13       122 LPKE--GDVVLARVTRISAQKVNVEILAVENE------PIPLDSGVGSNGAGKVAP---GGGSGASTFSVSQA------- 183 [Candida] glabrata
EDK43663     135 LPKE--NDIVLVRITRISQKQAWCEILAMENKhghfqkNILADSGLGSNGATSHASl-pAGGGSQHNFNIQSVasnt--- 208 Lodderomyces el...
Q75E69       130 LPKE--GDVVLTRVTRITLQRANVEILAVENT------NSPIDYGVGSKGSGIVAS-----NGGNTGFSMSQV------- 189 Eremothecium go...
3M7N_C        52 IPEIvkGDVVLGRVVDLRNSIALIEVSSKKGEnrgpsnRGIGILHVSNVDEGYVKEiseAVGYLDI-------------- 117 Archaeoglobus f...
XP_001542338 135 LPTV--DSVVLARVTRVQKRQATLSILVV----------------LDDNPSSPYPAttaAADGLPHSLLSTTNad----- 191 Histoplasma cap...
XP_001274632  95 LPAV--DSIVLARVTRVQKRQATVSILVV----------------LDASSSAQIPDsskTASDNDNIASILTSaanp--- 153 Aspergillus cla...
ABN67468     119 LPKE--NDVVLVKITKITQKQVYCEILSVEGHg-----NVLSDGGIGANGELAHDSl-pAGGGSQNLSNHQTIassqata 190 Scheffersomyces...
XP_001486345  90 LPKQ--GDVVLVRITRLNQKQAFCEILSVEDNk-----NVLLDSGIGAVGTTAHQSv-aVSGGASALTSQAAVasfqstl 161 Meyerozyma guil...
Q6BYH2       123 LPQE--GDVVLARITRLNPRQAFCEILTVEGHg-----NVLNDSGLGANGENAHRSi-pAGGGSQSLSSHTTIasqas-l 193 Debaryomyces ha...
5G06_I       194 ----SSDLGETFRGIIRSQDVRSTDRDRVK----------VIECFKPGDI--------VRAQVLSL 237 baker's yeast
EDO15415     184 ----SSDFGEPFRGILRSQDVRATERDRVK----------LIENFKPGDI--------IRAQVLSL 227 Vanderwaltozyma polyspora DSM...
Q6FP13       184 ----SSDLGETFRGMIRSQDIRATERDRVK----------VIESYKPGDI--------IRAQILSL 227 [Candida] glabrata
EDK43663     209 snaqIYDIGENFRGIIRSQDIRSTERDRVV----------VGECFKPGDI--------VRAQILSL 256 Lodderomyces elongisporus NRR...
Q75E69       190 ----PSDLGETFRGIIRSQDVRATNRDQVK----------MVEAFRPGDI--------VRAQVLSL 233 Eremothecium gossypii
3M7N_C       118 -----------LKARVIGDNLRLSTKEEEMgvlralcsncKTEMVREGDIlkcpecgrVEKRKIST 172 Archaeoglobus fulgidus
XP_001542338 192 ---pLNADDLRFQALIRKEDVRAVEKDRVV----------MDEMFRVGDI--------VRAVVISL 236 Histoplasma capsulatum NAm1
XP_001274632 154 -enhSNSDELRFQALIRKEDVRAVEKDRVV----------MDEMFRVGDI--------VRGTVISL 200 Aspergillus clavatus NRRL 1
ABN67468     191 lgaqSNDIGENFKGIIRSQDIRSTDRDKVK----------VIDSYKPGDI--------VRALIISL 238 Scheffersomyces stipitis CBS ...
XP_001486345 162 gkavAADLGETFKGIIRTQDVRLTDRDRVQ----------IVDCFRPGDI--------VRGMISSL 209 Meyerozyma guilliermondii ATC...
Q6BYH2       194 inavASDLGETFKGIIRTQDVRLTDRDRVK----------IIECFKPGDI--------VRAVIISL 241 Debaryomyces hansenii
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