4V25,2Q8F


Conserved Protein Domain Family
BCDHK_Adom3

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pfam10436: BCDHK_Adom3 
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.
Statistics
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PSSM-Id: 402181
View PSSM: pfam10436
Aligned: 292 rows
Threshold Bit Score: 69.0612
Threshold Setting Gi: 238033997
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4V25_A        31 PLSMKQFLDF---GSSN-----AcEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDK 102
CCD22423      95 PLSYGFLTNFkkkPLTSnekynL-TIKTINYLIS----YTCRQLNSIQNLPYIVITNPKINQINSLYLRTLEALLSKQF- 168 Naumovozyma dai...
XP_001629846  29 rLTPYQMLYA---GKFKdg--tH-LLKSAQYLHKELPIRIARRLKDFQQLPYIILSNPSIHDTYELYLRAFTSLTKYPK- 101 starlet sea ane...
XP_009027969 100 PISLFKLLKS------Sfn-kdH-LIKNARFLQQELPIRVAKRVVAFHMLPFIVASNPSLLRCQELYTSSFQLLKSCEPV 171 Helobdella robusta
XP_780213     74 rLTPATLLYT---GKSPdg--nH-LLRSAQYLHKELPVRVAHRIAEFRGLPFIVGCNPTILHVHELYIRAFHLLSEFPS- 146 purple sea urchin
EEC04863      68 rLTPTTILYS---GKSPdg--sH-LLRSAQYLHKELPVRIAHRIAGFRSLPFIVGCNPTILAVHELYTQTFYLLTDFPP- 140 black-legged tick
EKC41399      64 rLTPTTLLYA---GKSPdk--sH-LLRSAQYLHKELPVRIAHRIRGFRGLPFIVGCNPTILKVHEMYIRAFYILYEHPP- 136 Pacific oyster
EEN47883      72 rLTPTTILYA---GKSPdn--sH-ILRSAQYLYKELPVRVAHRIRDFRHLPFIVGCNPTILHVHELYIRSFHLLSEFPP- 144 Florida lancelet
ESN99119      60 rlmplTMLYS---GKSPdn--sH-LVKSAQYLQRELPIRFAHQVSRFRKLPFIAGVHPLILEVHDLYIRSFHNLNNFPPv 133 Helobdella robusta
XP_014351939  69 rLTPTTMLYS---GKSPdg--sH-LLKSARYLHMELPVRIAHRIKGFRNLPFIIGCNPTILQvHEMYIRAFHKLSEFPPi 142 coelacanth
4V25_A       103 --D--PEDHrtlSQFTDALVTIRNrHNDVVPTMAQGVLEYKdtygddpvsnQN-IQYFLDRFYLSRISIRMLINQHTLIF 177
CCD22423     169 --PydLYND---DLIIDLLKKLNNeHNDNLILLSNGLKEIHqdl----lsrKK-IFKFLDDHIKDRMSMKLIISNYLSLL 238 Naumovozyma dai...
XP_001629846 102 --IdnLESE---ERFSHLVKNLLDnHQHVVTNLAEGFQECkqh-----vsyET-MGNFLDRTLKSRLGIRMLAEHHLALR 170 starlet sea ane...
XP_009027969 172 tnTs---tE---EQFSETIQEMLDyHKEVVSLLSQGFKEAgky-----iedKKlIATFLDDMMKSRLGMRLLCDHHLQIP 240 Helobdella robusta
XP_780213    147 --IrdMDTE---RQYCKMVKTLLDdHKDVVTHLAEGFRECrkh-----itdESlIHNFLDRILTSRLGIRMLAEHHLFLH 216 purple sea urchin
EEC04863     141 --VtdFESE---SRYSETVQQVLDdHKDVVTQLAAGFKECrkh-----ikqEElVKTFLDRTLTSRLGMRMLAEHHIALR 210 black-legged tick
EKC41399     137 --VvdFASE---QVYSHTLRTLLDdHSNVVTMLAEGFSECrrh-----iqdEEmIRLFLDRMLKSRLGIRLLVEHHLALH 206 Pacific oyster
EEN47883     145 --VedFESE---EKYTKLVKDLLDdHKDVVTLLAEGFRESrkh-----ikeYKvIQEFLDRMLTSRLGIRMLAQHHIALH 214 Florida lancelet
ESN99119     134 --DsdFKDE---LAYCGVLKTFLEeHKNDVSLLTKGLKDVrnf-----vkeKNvLEDFLEKVLNSRIATELLCKHHIILQ 203 Helobdella robusta
XP_014351939 143 t---nREVE---AQYCKLLKQLLDdHKDVVTLLAEGFRESrkh-----ildESvLRLFLDKTLTSRLGIRMLATHHLALH 211 coelacanth
4V25_A       178 DGSTNpAHPk-----H-IGSID 193
CCD22423     239 APVQL-DDDp-----NmIGIVH 254 Naumovozyma dairenensis CBS 421
XP_001629846 171 FE------Kp-----NyIGMIC 181 starlet sea anemone
XP_009027969 241 IE------Rv-----SyVGSIE 251 Helobdella robusta
XP_780213    217 QD------Kn-----DsIGIIA 227 purple sea urchin
EEC04863     211 QD------Rp-----NhVGIIN 221 black-legged tick
EKC41399     207 DE------Ka-----NhVGIVD 217 Pacific oyster
EEN47883     215 QEK-----SlfhaqpNyVGIIC 231 Florida lancelet
ESN99119     204 KE------Ih-----GnIGIIt 214 Helobdella robusta
XP_014351939 212 DD------Kpdfvgiictrlsp 227 coelacanth
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