5O9Z,5IFE,5ZYA,5HY7


Conserved Protein Domain Family
MMS1_N

?
pfam10433: MMS1_N 
Mono-functional DNA-alkylating methyl methanesulfonate N-term
MMS1 is a protein that protects against replication-dependent DNA damage in Saccharomyces cerevisiae. MMS1 belongs to the DDB1 family of cullin 4 adaptors and the two proteins are homologous. MMS1 bridges the interaction of MMS22 and Crt10 with Cul8/Rtt101. Cul8/Rtt101 is a cullin protein involved in the regulation of DNA replication subsequent to DNA damage. The N-terminal region of MMS1 and the C-terminal of MMS22 are required for the the MMS1-MMS22 interaction. The human HIV-1 virion-associated protein Vpr assembles with DDB1 through interaction with DCAF1 (chromatin assembly factor) to form an E3 ubiquitin ligase that targets cellular substrates for proteasome-mediated degradation and subsequent G2 arrest.
Statistics
?
PSSM-Id: 402179
View PSSM: pfam10433
Aligned: 95 rows
Threshold Bit Score: 137.396
Threshold Setting Gi: 146447747
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5O9Z_WW        76 DYIVVGSDSGRIVIL--EYQPSKNMFEKIH-QETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVY---------- 142 
CAK43651      137 QILVLSLASKELVFLyfSNAS----GHFVYhRRPLPNDVSAFERFGRNIAVEPRSRAVAVSASSDYFGIFvlkrppviqa 212  Aspergillus n...
Q5B5Z3        119 QIMVLSLASKELVFLcySRAA----GQFIHcHRPLPSDVSTFERFGRNIAVEPRSRAVAVSASSDYFGVFvlkapsvvqa 194  Aspergillus n...
EED55595      100 QILLLSLASRELVFLyySMSS----DQFIHhHRPLPSDVSTFERFGRNIAVEPRSRAIAVSASSDYFGVFtlkqppvlqs 175  Aspergillus f...
Q0CR72        146 QILCLSLASRELVFLyySDAT----EQFIHyRRPLPSDVSTFERFGRNIAVDPRSRAVAVSASCDYFGVFilkkppilqn 221  Aspergillus t...
XP_001269754  148 QILVLSLASRELVFIyySTTS----GQFIHhHRPLPNDVSTFERFGRNIAVEPRSRAVAVSASADYFGIFmlrkppglqs 223  Aspergillus c...
XP_002483960  143 HILVLTLDSRELLFLycHNTSPENDMRFVHfRRALPSDVSISERFGRHLAVDPRSRAVAVAAPTDFFGVFmlkpqeelrl 222  Talaromyces s...
XP_002150305  112 HILALTLDSRELLFLycHSGSPDNDVGFVHfRRALPSDVSISERFGRHLAVDPRSRAVAVAAPADFFGVFmlkasgelhs 191  Talaromyces m...
CAP93506      112 QLLFLATDSDELLFMycSELG---DGRFVSySRPLPRDVNIADKYGKHIAVDPKSRAVAVSASRNFFGVLwlkypgelqm 188  Penicillium r...
EPS27901      116 QMLVLSLEMRELQFLyySTSG---DNKFVTfRRPLPVDVDLAERFGKHLAVDPKSRAIAVGASRHYFGLFflkssaeirh 192  Penicillium o...
5O9Z_WW       143 -ILNrdAAARltissPLEahk---------------------anTLVYHVVGVDVGF-En-PMFACLEmdyeeadNDPTG 198 
CAK43651      213 qMTQ--NRLD-----PIAeerf------------------frveGDIIAMEFLYPKSeDgdKITLLLL-------VAQDQ 260  Aspergillus n...
Q5B5Z3        195 qMLE--DQLD-----PVAeerf------------------frldGDIIFMDFLYPKSeDgdKIILLLL-------VSHEQ 242  Aspergillus n...
EED55595      176 qMAH--HQLD-----PISeerf------------------frvdGDIIFMEFLYPRPeDdgKILLLLL-------VAHDQ 223  Aspergillus f...
Q0CR72        222 qMSQ--VQLD-----PIAeerf------------------frveGDILFMEFLYPRPdDasKIMLLLL-------VAQDQ 269  Aspergillus t...
XP_001269754  224 qMVS--GRLD-----PIAeerf------------------frvdGDIMFMEFLYPKSeDgnKIILLLL-------VSHEQ 271  Aspergillus c...
XP_002483960  223 qLKE--GSLS-----PIAevcsrvsfilpffshkttqerfyrleGHILFMDFLYPSEeQndTIILQLI-------VARGP 288  Talaromyces s...
XP_002150305  192 qIKG--GTLA-----PIAeerf------------------yrleGHIMFMDFLYSPEnEknNIVLLLI-------VSRGP 239  Talaromyces m...
CAP93506      189 qMAQ--GKLN-----PLEifqqen---------------ffqvdGDILFMEFLYPKDiNdkRTILLLI-------VHRLG 239  Penicillium r...
EPS27901      193 qMSE--HRLD-----PIEsehf------------------ytceGSIQFMEFLYPKAaDdtMIILLVV-------SSTAD 240  Penicillium o...
5O9Z_WW       199 eaaantqQTLTFYELDLGLNHVVR--KYSEPlee------hgnFLITVPGgsdgpSG--VLICSENYITYKNFGDqpdiR 268 
CAK43651      261 l------TQAVCYEWDANESLRQAtpRV--TkkvlpledrlptMLIPLTK-----TSsfMLVTTTSITVYQNKLD----P 323  Aspergillus n...
Q5B5Z3        243 t------THAVCYEWNAHQSLRQShpRV--TrkslpaddrlptMLIPLTK-----ASsfMLVTTTTMTVYRNKLD----L 305  Aspergillus n...
EED55595      224 i------THAICYEWDASEHLRQAspIV--TkrllppedrlptMLIPLTK-----TSsfMLVTTSTMAVYKNRLD----P 286  Aspergillus f...
Q0CR72        270 i------THAICYEWDAQSPLRQAspRV--TkkllplddrlptMLIPLTK-----TSswMLITTTAMVVYRNGLD----S 332  Aspergillus t...
XP_001269754  272 m------THAICYEWHADETIRQAspRM--TrrvlpledrlptMLIPLTK-----TSsfMLITTTSMAVYKNRLD----P 334  Aspergillus c...
XP_002483960  289 d------THAVSYIWDTKKGIRQArsKP--VihqlpdfcrlpnLLIPLTK-----SSsfLLVTPSFIVFVPNALG----S 351  Talaromyces s...
XP_002150305  240 l------TYAMHYIWDSEKGVRQAqpKP--ItsklpdfcrlpnLLIPLTK-----SSnyLLITPSFIIINRNPLS----P 302  Talaromyces m...
CAP93506      240 t------TRSMVFEWDDASTISRVnpKITSTclphq--dqlpsMVIPLAK-----ESsyLLITTNSMAMYTPNCSsrpmr 306  Penicillium r...
EPS27901      241 g------SFAKIYHWDECD-MRPSqpTI--VefklrredrlptMIVPLTK-----ESsfLVVTSRSMAVY-PSDS----A 301  Penicillium o...
5O9Z_WW       269 Cp------------------------IPRRRNDlddpergMIfvcsatHKTKsmFFFLaQTEQGDIFKITLETdEDm-VT 323 
CAK43651      324 QrlpsryplpvyekesqksplwtrwaRPLRNWL-------YN------QKHD--DIYL-CREDGEITYLGIGT-DGelEN 386  Aspergillus n...
Q5B5Z3        306 PgppikypipvpdreqqksplwtrwaRPLRNAV-------YN------QMHD--DIYL-CREDGRIDYLGVGN-EGevEN 368  Aspergillus n...
EED55595      287 RrqpsryplglpdresrksplwtrwaRPLRNWL-------YN------QKHD--DIYL-CREDGQISYLGIGN-EGevEN 349  Aspergillus f...
Q0CR72        333 RqqpsryplrvpdreshrsplwtrwaRPLRNWQ-------YN------QRHD--DIYL-CREDGQISYLEIGN-DGgvEN 395  Aspergillus t...
XP_001269754  335 RrqpsryplpapdresqkaplwtrwaRPLRNWL-------YN------QRHD--DIYL-CREDGRVFYLGIGN-EGelEN 397  Aspergillus c...
XP_002483960  352 Klkiskhrcydli--snspsiwakwaRPYRHSK-------YD------KSHD--DVFL-CREDGRLTYVEIDN-KGnlGT 412  Talaromyces s...
XP_002150305  303 Nskrvkqrcsdli--skspsiwakwaRPYRHPK-------YD------ILHD--DVFL-CREDGRLTYVEIDN-KGqiES 363  Talaromyces m...
CAP93506      307 yppiipda------gsseaglwtrwaRPSRNWI-------YS------QRYD--GIFL-CQEKGWIYYLEFGN-DGelET 363  Penicillium r...
EPS27901      302 HprptkypliapddtfketslwtqwaRPARNWL-------YS------RKTD--GIYM-CREDGWIYFLEFGN-EGglES 364  Penicillium o...
5O9Z_WW       324 EIRLKYfDTVPVAAAMCVlkt-------gfLFVASEFGNHYLYQIAHLgddDeepefssampleegdtfffqprplkNLV 396 
CAK43651      387 QAHLGQ-LCCDVDAAFDIldigy--eggdlLLAAGTTGDGGLFVQKAR---D-------------------------HPR 435  Aspergillus n...
Q5B5Z3        369 QIQLGY-LFCDVDAAFDIldigy--eggdlLLAAGSTGDGGLFVQKAR---D-------------------------QPR 417  Aspergillus n...
EED55595      350 QAHLGQ-LCCDVDAAFDIlhfgn--eggdlLLAAGNTGDGGLFVQKAR---D-------------------------HPR 398  Aspergillus f...
Q0CR72        396 QTHLGQ-LCCDVDGAFDIldign--egddlLLAAGNTGDGGLFVQKAR---D-------------------------HPR 444  Aspergillus t...
XP_001269754  398 QAHLGR-LCCDVDAAFDIldigh--eggdlLLTAGTTGDGGLFVQKAR---D-------------------------HPR 446  Aspergillus c...
XP_002483960  413 INVIGQ-LDCDVDAAFDTidfnhpnhggdlLIAAGNTGHGGLFIQIAR---Q-------------------------NPT 463  Talaromyces s...
XP_002150305  364 INVIGQ-LDCEVDAAFDTidfnhpshggdlLIAAGSTGHGGLFIQTAR---Q-------------------------NPE 414  Talaromyces m...
CAP93506      364 QTSLGQ-LHCDVDMAFDIldmgh--eggdfILAAGSQGDGGLFVQEAR---D-------------------------HPR 412  Penicillium r...
EPS27901      365 QTSLGQ-LHCDVDSAFDIldvgh--eggdfILAAGSMGDGGLFIQEAR---S-------------------------KPR 413  Penicillium o...
5O9Z_WW       397 LVDELDSLSPILFCQIAdlan-------------edtPQLYVAC--GRGPRSSLRVLRHGLEVSEMA-VSELPGNP-NAV 459 
CAK43651      436 CVQKFMNWTPVTDSVVVksedttp--------sdiasdRLFVCSa-SSFSRGAVVELRHGVEAQIGLiVALEELSGtRDI 506  Aspergillus n...
Q5B5Z3        418 CVQRFTNWSPVTDSVIVkqapsqnt-----aadcvvgdRLFVCSa-SSFGRGAVVELRHGIEAQVGLlISLEELSGaRDI 491  Aspergillus n...
EED55595      399 CVQKFMNWSPVTDSVIVkssnqqfp-----lsadiasdRLFVCSt-SSFAQGAIVELRHGIEAQIGLvVSLEGLSGtRDI 472  Aspergillus f...
Q0CR72        445 CVQKFMNWTPVTDSVLVkgqsedls------stgvssdRLFVCSa-SSFARGAIVELRHGIEAQIGLaISVEELTStRDL 517  Aspergillus t...
XP_001269754  447 CVQKFINWTPVTDSVVVsgsrdps-------aseaasdRVFVCSa-SPFARGAIVELRHGLEAQIGLvVSLEELTStRDI 518  Aspergillus c...
XP_002483960  464 CVQRFVNWAPVFDTVIVppvqrdasnevhimenvnndLKIYVCSa-SSSNSGAVYEFRHGNEAQIGMiISLEDFPAaQSI 542  Talaromyces s...
XP_002150305  415 CVQRFVNWAPVFDTVIVpplqkkaghefdmtkdlsddLHLYVSSa-SSNNSGAVYEFRHGYEAQIGMiIPLEDFTTaRAV 493  Talaromyces m...
CAP93506      413 CVQRFVNWAPVLDAAVIpsntsalf-----kdtpydhDRLFVCSt-SASGNGAITELRYGIEAQIGVsAALGELSSiRGM 486  Penicillium r...
EPS27901      414 CVQRFLNWAPVTDAVMIraeihedr------kndvsrdRLFVCSasSAAGGSAIHELRHGFEAQAGYtISLDDFSGvRDM 487  Penicillium o...
5O9Z_WW       460 WTVRrhiedeFD-AYIIVSFVNATLVLSI----GEtvEEVT----DS-GFLGTTPTLSCSLLGDDALVQVYPDGIrhira 529 
CAK43651      507 WTMPdg---sTGgVFVLTSDPMSSLLLYLp---ADfgEELCaideAEsGLDSSTQTLAAGCTVSGAIIQVTDRTV----- 575  Aspergillus n...
Q5B5Z3        492 WILPds---iNGgVLMLTSDPVSSAFLYLp---TDftEEISaideADcGLDSNSPTLAAGYIEPGMLVQVTDKAI----- 560  Aspergillus n...
EED55595      473 WTMStg---tNGgVIVLTSDPMSSVLLDLp---ADfdEEICaideADsGLDCGSQTLAAGSTDIGVIVQVTERAI----- 541  Aspergillus f...
Q0CR72        518 WTMPdd---aKGgVFVLTSDPISSMLLHIp---SDfgEEICaideADvGLNFGAQTLAAGCSDSGVIVQVTDKSI----- 586  Aspergillus t...
XP_001269754  519 WTMSne---vGGgVFILFSDPVSSILLYLp---SDfgEEMCaideADsGLEFSAQTLAAGCTSSGVIVQVTEKAI----- 587  Aspergillus c...
XP_002483960  543 WVIPdm---tQEgTYFLISDPMSSVLMHLsrneGDdgEDIYavdgSDlALDLSVHTLAAGHTLTGVLVQVTPNTV----- 614  Talaromyces s...
XP_002150305  494 WVIPdf---sQDgTYFLISDPISSALMHLsrneSGegDEIYavdgSDlSLDLSVNSLAAGYTSTGVLFQVTSNAV----- 565  Talaromyces m...
CAP93506      487 WAVSlg---tSDsIYLLASDPLSSLLLHTt---PDmrDGITal-qNDaELEIQQ-TLAMDCTPSGVIVRVTEKVV----- 553  Penicillium r...
EPS27901      488 WAFSed---aNGgAYLLFSHPTSTLVLFMn---PDyeDIICaldeNEtGFE-NALTLAAGLTPTGVLVQATQNGT----- 555  Penicillium o...
5O9Z_WW       530 dkRVnewKTPg-K------K-----TIvkcavnQRQVVIALTGGELVYFEMdpsgqLNEYTERKEMSa-------DVVCM 590 
CAK43651      576 --CV----GAtpEmpgyrsEvgpgqTIvvaavdGPASLIAAVVRTQDEVRL-----HFKKLTSDGqhql--ldvaTPSLI 642  Aspergillus n...
Q5B5Z3        561 --FM---GATtdAqfrsrsDldigqSVaaaavhGPTCLVITAIRTHQELQI-----RSKRITQLGIdlql-seiiPPFNI 629  Aspergillus n...
EED55595      542 --HL---GATfeSmrssrfEygydqSItvaavnGSASLIVAAVRDQDGLHL-----HAKRLTPSGDqlsl-tdvgEPLRM 610  Aspergillus f...
Q0CR72        587 --RL---GAIseMlsksrlDydsgkYItaaavdQSACLIVAAIRSQHQMYL-----EFKRITLSDDspql-ldvcQALTI 655  Aspergillus t...
XP_001269754  588 --LL---ETVsgStlktrfDyddeqSVavaainRSASLIVTAVRTRHEVHL-----YAKRAGISDDevql-fdleDPSKL 656  Aspergillus c...
XP_002483960  615 --RS---MLLnkShlncvsNfpleqTAfvatvnEESGLVAVVLRSEQGITI-----QVGKVMLNDDslni-dftgTTVDV 683  Talaromyces s...
XP_002150305  566 --RA---VLLnnPeincvsDfsidqTVlvatlsEELELVAVALRSEQGISI-----QVGRAILNDCslni-dftgKTIHV 634  Talaromyces m...
CAP93506      554 --HF---FFPtaFhlssciQhdplvFVtaaivdGPSSTIIMTTRSEKGNFL-----HLLRIVVTEEGsaslsdheAPYPL 623  Penicillium r...
EPS27901      556 --NF---FVPlhPernssiPhklgaSIiavavdSTNSAMVVADRSENGLSL-----TLCRIILTDsavd--lqksEPFQI 623  Penicillium o...
5O9Z_WW       591 SL 592 
CAK43651      643 QH 644  Aspergillus niger
Q5B5Z3        630 DY 631  Aspergillus nidulans
EED55595      611 HF 612  Aspergillus flavus NRRL3357
Q0CR72        656 QY 657  Aspergillus terreus NIH2624
XP_001269754  657 PY 658  Aspergillus clavatus NRRL 1
XP_002483960  684 GY 685  Talaromyces stipitatus ATCC 10500
XP_002150305  635 EH 636  Talaromyces marneffei ATCC 18224
CAP93506      624 QK 625  Penicillium rubens Wisconsin 54-1255
EPS27901      624 ER 625  Penicillium oxalicum 114-2
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap