2VR3,4B60


Conserved Protein Domain Family
SdrG_C_C

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pfam10425: SdrG_C_C 
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C-terminus of bacterial fibrinogen-binding adhesin
This is the C-terminal half of a bacterial fibrinogen-binding adhesin SdrG. SdrG is a Gram-positive cell-wall-anchored adhesin that allows attachment of the bacterium to host tissues via specific binding to the beta-chain of human fibrinogen (Fg). SdrG binds to its ligand with a dynamic "dock, lock, and latch" mechanism which represents a general mode of ligand-binding for structurally related cell wall-anchored proteins in most Gram-positive bacteria. The C-terminal part of SdrG(276-596) is integral to the folding of the immunoglobulin-like whole to create the docking grooves necessary for Fg binding. The domain is associated with families of Cna_B, pfam05738.
Statistics
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PSSM-Id: 402173
View PSSM: pfam10425
Aligned: 10 rows
Threshold Bit Score: 113.287
Threshold Setting Gi: 122540119
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2VR3_A         157 GKFYNLSIKG----TIDQIDKTN--NTYRQTIYVNPSGDNVIAPVLtgNLKPNtds----naLIDQQNTSIK-------- 218  Staphylococc...
Q2G0L5         336 GNKKAQPLIS----STNYINNED--LSRNMTAYVNQPKNTYTKQTFvtNLTGY---------KFNPNAKNFK-------- 392  Staphylococc...
Q2FUY2         367 DKPNGANISS----QIIGVDTASgqNTYKQTVFVNPKQRVLGNTWV--YIKGYqdkieessgKVSATDTKLR-------- 432  Staphylococc...
Q2G0L4         397 VVNEKNSIGSafteTVSHVGNKEnpGYYKQTIYVNPSENSLTNAKL--KVQAYhssypnnigQINKDVTDIK-------- 466  Staphylococc...
4B60_B         157 IGNYYANLNG----SIETFNKAN--NRFSHVAFIKPNNGKTTSVTVtgTLMKGs--------NQNGNQPKVR-------- 214  Staphylococc...
Q2G1T5         291 RDNWGVTANG----RIDTLNKVD--GKFSHFAYMKPNNQSLSSVTVtgQVTKGn--------KPGVNNPTVK-------- 348  Staphylococc...
BAG07604      4232 eggnTPNMTS----KIVSFDRET--GEFVQYYYINRDKTLTKSAEFeyTPSEA--------------VTNLKfdyyalrq 4291 Finegoldia m...
jgi:Lreu_0082  220 ANDMFLGISS----RMMHFDKDQ--QLFEDIIYVNPAQKDLNHAYIvfNTSDLveel--snaVVKPSTMRVE-------- 283  Lactobacillu...
Q8DYL7         475 HTNVKTNVRS----RIMKLDDER--QTETYITQINPEGKEMYFASGlgNLYTIigsdgtsgsPVNLLNAEVK-------- 540  Streptococcu...
Q5HRI6         389 NENRTANLQS----MFTNIDTKN--HTVEQTIYINPLRYSAKETNV--NISGNgde----gsTIIDDSTIIK-------- 448  Staphylococc...
2VR3_A         219 ----VYKVDNAA-------DLSESYFVN---PENFEDVTN--Sv-----------NITFPNPNQ-YKVEFNTPddqiTTP 270  Staphylococc...
Q2G0L5         393 ----IYEVTDQN-------QFVDSFTPD---TSKLKDVTDqfD------------VIYSNDNKT-ATVDLMKGqtssNKQ 445  Staphylococc...
Q2FUY2         433 ----IFEVNDTS-------KLSDSYYADp-nDSNLKEVTDqfKn-----------RIYYEHPNV-ASIKFGDI----TKT 484  Staphylococc...
Q2G0L4         467 ----IYQVPKGY-------TLNKGYDVN---TKELTDVTNqyLq-----------KITYGDNNS-AVIDFGNA----DSA 516  Staphylococc...
4B60_B         215 ----IFEYLGNNe------DIAKSVYANttdTSKFKEVTSnmSg-----------NLNLQNNGS-YSLNIENL----DKT 268  Staphylococc...
Q2G1T5         349 ----VYKHIGSD-------DLAESVYAKlddVSKFEDVTDnmS-------------LDFDTNGG-YSLNFNNLd--qSKN 401  Staphylococc...
BAG07604      4292 nsgnIYDYNKGQyvdpivkDMPESFGVDe-nSYNLNWYYT--Dg-----------YYNLGAGQT-QKISLGTLg--kDNS 4354 Finegoldia m...
jgi:Lreu_0082  284 ----IYRNSRGL-------KLPQSYGVN---LQRLRDITNrfPvvegdhlveapyTMSFADNK--MRLNFGADq--tNDS 345  Lactobacillu...
Q8DYL7         541 ----ILKTNSK--------NLTDSMDQNy-dSPEFEDVTS---------------QYSYTNDGSkITIDWKTNsissTTS 592  Streptococcu...
Q5HRI6         449 ----VYKVGDNQ-------NLPDSNRIYd--YSEYEDVTN--Dd-----------YAQLGNNND-VNINFGNI----DSP 497  Staphylococc...
2VR3_A         271 YIVVVNGHIDPNSKGDLALRSTLYGYNSNIIWRS------MSWDN 309  Staphylococcus aureus
Q2G0L5         446 YIIQQVAYPDNSSTDNGKIDYTLDTDKTKYSWSNs-----YSNVN 485  Staphylococcus aureus subsp. aureus NCTC 8325
Q2FUY2         485 YVVLVEGHYDNTGK---NLKTQVIQENVDPVTNRdy--siFGWNn 524  Staphylococcus aureus subsp. aureus NCTC 8325
Q2G0L4         517 YVVMVNTKFQYTNSESPTLVQMATLSSTGNKSVStg--naLGFTN 559  Staphylococcus aureus subsp. aureus NCTC 8325
4B60_B         269 YVVHYDGEYLNGTD-EVDFRTQMVGHPEQLYKYYydrgytLTWDN 312  Staphylococcus aureus subsp. aureus NCTC 8325
Q2G1T5         402 YVIKYEGYYDSNAS-NLEFQTHLFGYYNYYYTSN------LTWKN 439  Staphylococcus aureus subsp. aureus NCTC 8325
BAG07604      4355 LILKVTGKVKAENIASYDTYAKMYGYYTEKWTDY------YGYSH 4393 Finegoldia magna ATCC 29328
jgi:Lreu_0082  346 YIIRVVGQYNDELDGTVRLRARLFGMDQQNVYMS-------NSTA 383  Lactobacillus reuteri DSM 20016
Q8DYL7         593 YVVLVKIPKQSG-----VLYSTVSDINQTYGSKYs-----YGHTN 627  Streptococcus agalactiae serogroup V
Q5HRI6         498 YIIKVISKYDPNKDDYTTIQQTVTMQTTINEYTGef--rtASYDN 540  Staphylococcus epidermidis RP62A
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