Conserved Protein Domain Family

pfam10417: 1-cysPrx_C 
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C-terminal domain of 1-Cys peroxiredoxin
This is the C-terminal domain of 1-Cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily which protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding alcohols. The C-terminal domain is crucial for providing the extra cysteine necessary for dimerization of the whole molecule. Loss of the enzyme's peroxidase activity is associated with oxidation of the catalytic cysteine, upstream of this domain; and glutathionylation, presumably through its disruption of protein structure, facilitates access for GSH, resulting in spontaneous reduction of the mixed disulfide to the sulfhydryl and consequent activation of the enzyme. The domain is associated with family AhpC-TSA, pfam00578, which carries the catalytic cysteine.
PSSM-Id: 402167
View PSSM: pfam10417
Aligned: 43 rows
Threshold Bit Score: 35.238
Threshold Setting Gi: 158510999
Created: 21-May-2020
Updated: 7-Aug-2020
Aligned Rows:
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Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
5OVQ_B       160 ALQTADREGvATPADW-VPepqtwefteeNTKVIVPPPTTYEDA--VKRLQEG 209 Aquifex aeolicus VF5
Q2GG97       158 AIKHHQVHGeVCPAGW-MK----------GDPAM---EASQH-G--IEDYLKS 193 Ehrlichia chaffeensis str. Arkansas
CAM80190     160 AIDFHKKYGdVCPAGW-TP----------GTEGI---EATSD-G--ICHYLTS 195 Orientia tsutsugamushi str. Boryong
A0DQB3       161 AFKFTDEHGeVCPAQW-KP----------GQPTLVTNHSDPK----TQKYWNE 198 Paramecium tetraurelia
XP_001326926 157 AYQFAAKHGeVCPAQWhGE----------GDLTI---KADPK-A--SKEYFNK 193 Trichomonas vaginalis G3
Q9VUM4       159 AFQFSDEFGeVCPVNW-RP----------GAKTM---KADAT-G--KEEYFKH 194 fruit fly
Q22AJ2       161 AFQFVEEHGeVCPAKW-KP----------GAKSMVPDHNSSK----LKEYWEN 198 Tetrahymena thermophila SB210
Q7M8C0       191 AWQHATQTGeVCPAGW-RP----------GKKTLPVNTDAEKMTgrVGDYITL 232 Wolinella succinogenes
Q4CX87       191 AFQYVDKNGdVIPCNW-RP----------GKPTM----KTEK----ANEYFEK 224 Trypanosoma cruzi
XP_001704832 206 AFQYADKTGgVIPCGW-TP----------EKNDFI--IPDPE-K--KKEYFSK 242 Giardia lamblia ATCC 50803
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