1BOB


Conserved Protein Domain Family
Hat1_N

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pfam10394: Hat1_N 
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Histone acetyl transferase HAT1 N-terminus
This domain is the N-terminal half of the structure of histone acetyl transferase HAT1. It is often found in association with the C-terminal part of the GNAT Acetyltransf_1 (pfam00583) domain. It seems to be motifs C and D of the structure. Histone acetyltransferases (HATs) catalyze the transfer of an acetyl group from acetyl-CoA to the lysine E-amino groups on the N-terminal tails of histones. HATs are involved in transcription since histones tend to be hyper-acetylated in actively transcribed regions of chromatin, whereas in transcriptionally silent regions histones are hypo-acetylated.
Statistics
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PSSM-Id: 402148
View PSSM: pfam10394
Aligned: 166 rows
Threshold Bit Score: 71.4075
Threshold Setting Gi: 74778847
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1BOB_A        11 WTSSANEALRVSIVGEN-AVQ------FSPLFTYPIYGDSEKIYGYKDLIIHLAFDSVTFKPYVNVKYSAKLgdDni--- 80  baker's yeast
XP_003055477  64 FVCDANDVVTFRLVSSAeEMTta--eaFEPEFTHQIFREDETIFGYKDLRVNVYATAGTFRTYVEVTYSEKV--Kstlnp 139 Micromonas pusi...
XP_006367962  28 AGIEANDCITIYIVSSAeDVDspssfcLEPIDLNQFFEDDGRIFGYQGLKITIWVSLISFHAYADISFESssdgg---rg 104 potato
XP_002514170  28 SGIEANECITIYMVSSReQVGasdsfcISPVDLNGFFDEAGKIYGYQGLKITIWISSLTFHAYADITYEStsdgg---kg 104 castor bean
XP_002282931  27 TGVEAKDCIKIFLVSRKdEVGasdsfcIDPVDLNSFFEEDGKIYGYQGLKITVWINSISFHSYANITFQStsdgg---kg 103 wine grape
KRH73079      28 SGVEAKDCITIYLVSSKeEFDapesfvIHPVDLNSFFDDDGKIYGYEGLKITIWISSISFYAYADITFQSssdrg---kg 104 soybean
Q8LPU4        30 AGVEANECMKVFLVWNPgEVSsvdctaIQPFDLNHFFGEDGKIYGYKNLKINVWISAKSFHGYADVSFDEtsdgg---kg 106 Zea mays
Q6ES10        27 AGVEANECMKVFIARNPdEAGsanstsLQPFDLNHFFGEDGKIYGYKNLKINVWISAISFHAYADISFEEtsdgg---kg 103 Japanese rice
XP_003578012  29 AGIEANECMKVFLARNPdDVCsvnntsIEPFDLNHFFGEDGKIYGYTNLKINVWISAISFHAYAEISFQEtsdgg---kg 105 stiff brome
XP_020156291  28 AGTEANECMQVFLARNPdEVGsadstpIEPFDLNHFFGEDGKIYGYTNLKINVWISAISFHAYAEISFQEtsdgg---kg 104 Aegilops tausch...
1BOB_A        81 -vDVEKKLLSFLPKddviVRDEAKWVDCFaeERK-THNLSdvFEKVSEYslNGEE---------------FVVYKSSLVD 143 baker's yeast
XP_003055477 140 adDVVAALRKHFGDe--mLVDRDAFLAALa-KDAsAPIPGggGEVVSRW--TADGddeh--------ectVRVFK--LAD 204 Micromonas pusi...
XP_006367962 105 itNVKYALQNIFAEs--lVDEKDAFLQTFstESHyVRSVVsnAETLQHK--VSNGcstesncllksepsdVEVFR--IAG 178 potato
XP_002514170 105 itDLKNALQRIFAEt--lVENKDDFLRSFsaESHlIRSIVstGEIFHHK--ASNGyigeshl--geptsdMKVFRMAIGN 178 castor bean
XP_002282931 104 itDLKSALQTIFAEt--lVETKDDFLQTFstERHyIRSMVsnGEILQHK--ASIGhssnsg---raedsdLEVIRMVMGN 176 wine grape
KRH73079     105 vtDLKSALQTIFAEt--lVDSKDEFLQKYlaDNDfVRTNIsnGETLKHK--AFKEnicdsnqltdsststVEVVRLVAGN 180 soybean
Q8LPU4       107 itDLKPVLQNIFGEn--lVE-KEEFLHTFskECEyIRTAVtnGSAIKHD--GSYEsd-----------paVEIVRVELQG 170 Zea mays
Q6ES10       104 itDLKPVLQNIFGEn--lVE-KDEFLKTFskECEyLSNVVtdGNVIKHD--ASIDed-----------saVEIVRVELQG 167 Japanese rice
XP_003578012 106 itDLKPVLQSIFGEn--lVE-KDEFLETFskECQyISDVVtnGNPIKHD--VSDEgd-----------ldVEIVRVELQG 169 stiff brome
XP_020156291 105 itDLKPVLQNIFGEn--lVE-KDEFLEAFskECQcISDVVtnGNSIKRD--ASGEdd-----------lsAEIVRVELQG 168 Aegilops tausch...
1BOB_A       144 DFARrMHRRVQIFSLLFIE 162 baker's yeast
XP_003055477 205 EDVYpWHARFEPFTLFYID 223 Micromonas pusilla CCMP1545
XP_006367962 179 TPVGhLYSRLVPLVLLLVD 197 potato
XP_002514170 179 TGAGhLYSRLIPLVLLLID 197 castor bean
XP_002282931 177 MAAGhLYSRLIPLVLLLVD 195 wine grape
KRH73079     181 MATGqLYSHLIPLTLLLVD 199 soybean
Q8LPU4       171 AAAf-LYSRLVPLVLLLVE 188 Zea mays
Q6ES10       168 AAAf-LYCRLVPLILLLVE 185 Japanese rice
XP_003578012 170 APAf-LYSRLVSLVLLLVE 187 stiff brome
XP_020156291 169 AAAy-LYSRLVSLVLLLVE 186 Aegilops tauschii subsp. tauschii
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