Conserved Protein Domain Family
Clr2

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pfam10383: Clr2 
Transcription-silencing protein Clr2
Clr2 is a chromatin silencing protein, one of a quartet of proteins forming the core of SHREC, a multienzyme effector complex that mediates hetero-chromatic transcriptional gene silencing in fission yeast. Clr2 does not have any obvious well-conserved domains but, along with the other core proteins, binds to the histone deacetylase Clr3, and on its own might also have a role in chromatin organisation at the cnt domain, the site of kinetochore assembly.
Statistics
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PSSM-Id: 402139
View PSSM: pfam10383
Aligned: 31 rows
Threshold Bit Score: 85.5125
Threshold Setting Gi: 353239977
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAC75074          439 HYQGLYFGTERIWVGDVVRLKLSANDvqklqrelntalvadKLPGAPDPKAIMLDEDGSYVLQLSAIYEDPRAPKVQRVA 518 Moesziomyc...
CAZ79782          391 FYAGVFYGAEKIWMGEIVRLKRHAVP------------------QANLTGLEIMIVVSIQDHRKQPPNKTRTFSTDITVM 452 Perigord t...
CCA71866          399 sYQGLWLGAERIWLHDLVRLRLTHSElvkhpk---lhdqifYPTEGSETRALFMRINDIHVE-------EAPVRETVRLI 468 Serendipit...
XP_007404741      529 WYQSVWWGAEKIWIFDTVRLNKVESDlpmelfknqlnsklnLNHIDSNDKAYFLKIDGIY---------RDEIEETIILI 599 Melampsora...
EFX02622          402 iYGGVFLGAEQIVVGDAVRVDARRDGaadgngngngssnsnNGGDLPPGTTDIMRINLI-----------LTDHDHLRFI 470 Grosmannia...
CAP71486          350 cFQGVYFGAEMIMVNDPIRVQLGLPAdgs----------qqQPADASVPAVGIMHVEQIQYLIPTGQQN---SKPVLRFQ 416 Podospora ...
EGS21576          407 HYEGVYLGAEMIRIGDPIRVTVRSSViadssv---aateaiIAATVPPDATVVMLIDSIEVLFPAAPPH----RWYLQFR 479 Chaetomium...
XP_003649767      360 HYGGVYLGAEMVRVGDPIRVTAQPTSgip---------dqtVAGDIPPDAALVMLVSEIEVLTPTAPTP-TTTPTRLQFR 429 Thermothie...
Q2H122            372 HYGGIYLGAEMVRIGDPVRVINAPSAttpg-------gagpAQPDLPPDANLIMLITEIQVLTPTSPPG--GARATLQFK 442 Chaetomium...
jgi:MYCTH_2298606 356 HYGGVYLGAEMVRVGDPVRVVATPSGspsqqqqqhqqqqasQQAALPPDANLVMLVTEIQVLTPSSLTGDARGAATLQFK 435 Thermothel...
GAC75074          519 GEMYEILSTTKLKQlqdamaaskeeVLANEAldeaMRQEEAkllEArmpkpsilsg------------------------ 574 Moesziomyc...
CAZ79782          453 GDIYEFVTY----------------PFPTSPppqiPQWLPPrliNE---------------------------------- 482 Perigord t...
CCA71866          469 CRITGPILCTVPDPkfvhtderfltSSASNAfpgidngr----------------------------------------- 507 Serendipit...
XP_007404741      600 GKVYDLVSVSSFTPk---------kSLPNHKpnakPKPSIVvviDDddddeeeeedktksrstpkitkltnvpilptipe 670 Melampsora...
EFX02622          471 GDVYRLALTTAA-------------AGSNSNasatAPPEGQlfaEE---------------------------------- 503 Grosmannia...
CAP71486          417 GKLIRPVRAPAGV------------PPPGAAp---PDTLGPvcaEE---------------------------------- 447 Podospora ...
EGS21576          480 GSLYRPYRRSMSEP-----------VPSNAVl--qPASLGQvfsEE---------------------------------- 512 Chaetomium...
XP_003649767      430 GNLYRPIRAPTTA------------PPTNAVp---ADSLGPvfiEE---------------------------------- 460 Thermothie...
Q2H122            443 GNLYRTARLSSTHP-----------PPQGTVppaaEASLGAafvEE---------------------------------- 477 Chaetomium...
jgi:MYCTH_2298606 436 GDLYRAARLSTAHP-----------PPPGTIp--sGETLGPafaEE---------------------------------- 468 Thermothel...
GAC75074          575 ---rpgfpplppLPPGFVMVSLsdrl--------------qsrIPRETTLS--------------IGHVAGRLYP 618 Moesziomyces an...
CAZ79782          483 -------------------TKLknkvtsrassnptvgtwrciqNGYSVKLE----------------DIKGRWYE 522 Perigord truffle
CCA71866          508 ----hfplplppLGFKYHPVTV---------------------TTEEVTVD--------------AQMIAGRYYP 543 Serendipita ind...
XP_007404741      671 dssdtsfkylpiPPKGYKFRQLtpfge---------------------------------shhvhLNCIAGRYYs 712 Melampsora lari...
EFX02622          504 -------------LEDRNGIMLaantqknqq----qqrwywhlKERNGHRA--------------ENEVHGRFYV 547 Grosmannia clav...
CAP71486          448 -------------IAGRNAFEKnksmaw----------ywvvlSLKTLQPAateedrqfttttklEGDVLGRFYV 499 Podospora anser...
EGS21576          513 -------------MAMRNQIEPrartgmewvw--lrlgtdgpgPAQAVVRA--------------EQDVLGRFYV 558 Chaetomium ther...
XP_003649767      461 -------------LKTRNAIERdpgarw-----------twvlaAARAVRG--------------EPDVQGRFYV 497 Thermothielavio...
Q2H122            478 -------------LATRNAIGKdkgarw-----------swvlvAAQVLRG--------------EHDVQGRFYV 514 Chaetomium glob...
jgi:MYCTH_2298606 469 -------------LATRNAIDKesnpdggnad--kavfwswvqvGAQVLRG--------------EQDVQGRFYV 514 Thermothelomyce...
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