Conserved Protein Domain Family
NT-C2

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pfam10358: NT-C2 
N-terminal C2 in EEIG1 and EHBP1 proteins
This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.
Statistics
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PSSM-Id: 402120
View PSSM: pfam10358
Aligned: 57 rows
Threshold Bit Score: 55.7908
Threshold Setting Gi: 123433057
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002552492   11 RRPKFLFNLKINELTNIPQ--SSGYCFVKW-HLKDGTgttshtiipeigspqsnvksssqsrGATPRVLVKSHRAHWNYS 87   Lachancea the...
XP_001326174    5 QVMNYIAFILVEKVQFPEK--YNKPLFIRVqRKKTAGgqtkl----------------afssETSYKNLDNNLIAHFDNE 66   Trichomonas v...
EAX99489        7 KSTPHHCFILIEKITFSKK--VDVPVFIRVaRKKSSGgvfkt----------------ayssETSFQLADQSNIVQFNNE 68   Trichomonas v...
EAY18871        7 DSTPHYAFISIEKVSFSKS--VNVPVYVRVeRKKSTSgimrk----------------afhsETRFQLADSNNIVQFNNE 68   Trichomonas v...
XP_001308733    7 KSTPHFSFILIEKVAFTKK--VDVPVFVRVeRKKSSAgvmkk----------------afnsETKFQLADSNNIVQFNNE 68   Trichomonas v...
XP_001324177    7 QSLKCYCILHIESIKFEKD--IKFPVFIRVaRVRKSGiferv----------------afnsETNYSMLDANLVAQFDCE 68   Trichomonas v...
XP_001308543    4 PSYFIFYVQKIEYPRMIYS--QYTLTYITVeLQKVTLgikhs----------------sekvRSKTATLDNANCGVFECE 65   Trichomonas v...
XP_002871949   76 RRFNCCFSAQVHSIEGLPPifQDLSLTVHW-KRRDEs-------------------------LSTRPAKVSNGRAEFKDK 129  Arabidopsis l...
Q7Y219         87 RRFDVCFLLHVHSIEGLPLnlDGTKLVVQW-KRKDEv-------------------------MTTQPSKVLQGTAEFEET 140  thale cress
Q55BH2         18 EDIKISYVVKIVKVTGLPKs-SYSPLLVSW-KRGSKKe-----------------------nSGEVKTIPRDGEGVVDHT 72   Dictyostelium...
XP_002552492   88 LQKPVQVKLVt---DKNKNLNSKEMVLEVYFEFleptnashgkfqhsrqlsdasstnssasssnsnvyTQKVsrkMLLGV 164  Lachancea the...
XP_001326174   67 FSLPFTTV------KKGDKYVKKVVEIQLVSVSn---------------------------------kKKEE---VEICK 104  Trichomonas v...
EAX99489       69 FQIPITIFT-----KKGEEPQKKMLEVSCLAIMs---------------------------------kKEPE---HQVCT 107  Trichomonas v...
EAY18871       69 FRIPVTIFS-----KKGEKPQKKVVEISCIVVGs---------------------------------sKASE---HTACT 107  Trichomonas v...
XP_001308733   69 FQIPVTIFT-----KKGEKPQKKVVEITCLSVAs---------------------------------kKEPE---KVVCT 107  Trichomonas v...
XP_001324177   69 FIIPITLYQ-----KEGHKLEKKILDIEIFSLDk---------------------------------nQGQN----CISK 106  Trichomonas v...
XP_001308543   66 -----ACFN-----NPKQDNKQKLIHIVIGAVQd----------------------------------SEI-----EIGS 96   Trichomonas v...
XP_002871949  130 LTHTCSVYGSrsgpHHSAKYEAKHFLLYVAQVg-----------------------------------SPEI----DLGK 170  Arabidopsis l...
Q7Y219        141 LTHRCSVYGSkhgpHRSAKYQVKLFLIYVSPVd-----------------------------------APWL----VLGK 181  thale cress
Q55BH2         73 INLNATITKT----PKGF--LEKSIQFTVKEEk-----------------------------------LGKKp--VSLGS 109  Dictyostelium...
XP_002552492  165 VEVNIAEYVNRE-------QHMVTSRFLLQKS--KVNSILSLGIQLELTRGSF 208  Lachancea thermotolerans CBS 6340
XP_001326174  105 WRFDASNMPD---------PRDPSVHFSVASSd-FGNVNLYVRFCVIPAEEFS 147  Trichomonas vaginalis G3
EAX99489      108 WKFDAANLLD---------PKDSSVQTSMTKCe-FGIATLYLRIVVLPESDFP 150  Trichomonas vaginalis G3
EAY18871      108 WRFDAANLPN---------PKDSSIQTAQAKCe-FGVATLYLRFNL------- 143  Trichomonas vaginalis G3
XP_001308733  108 WKFDLANLAD---------PKDSSVQTSQTKCd-FGIATLYIRIVLIPETDYP 150  Trichomonas vaginalis G3
XP_001324177  107 VRMDIANLTDP--------RSTARQTSNFQTNk-FGTAQLNFRLCVLPIDEFP 150  Trichomonas vaginalis G3
XP_001308543   97 IDLDLEDIDK---------HKSKLAIKKIRFGk-HQKGKLYYRAIVLPITFFP 139  Trichomonas vaginalis G3
XP_002871949  171 HRMDLTKLLPLTleelqdeKSSGKWSTTFQLTgkANGATLSMSFGYTVVGDTR 223  Arabidopsis lyrata subsp. lyrata
Q7Y219        182 HWIDLTRILPLSleemegtRSTRKWNTSFKLSglAESAVLNLSFDYSVVTSSV 234  thale cress
Q55BH2        110 VSVNLAQYAEs--------KTEKTHPFPIQDKs-KVVCNLYLSIQSSWLKVNG 153  Dictyostelium discoideum AX4
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