Conserved Protein Domain Family
DUF2428

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pfam10350: DUF2428 
Putative death-receptor fusion protein (DUF2428)
This is a family of proteins conserved from plants to humans. The function is not known. Several members have been annotated as being HEAT repeat-containing proteins while others are designated as death-receptor interacting proteins, but neither of these could be confirmed.
Statistics
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PSSM-Id: 402115
View PSSM: pfam10350
Aligned: 141 rows
Threshold Bit Score: 117.415
Threshold Setting Gi: 219127379
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004366355  1064 QMVADLIGLMFSVSKVVLRVVA--------DIAPEG----Y----------TPKQEEGAAVNnNNnndnslpkslpsgvl 1121 Cavenderia f...
EGR31610       508 KTLTNLFQIMSKILNFTTQISSetvysiftQKENNDnffkNnqlqidcrghIVNEKAQFVQNmQKilqgntllealk--- 584  Ichthyophthi...
XP_002183914  1071 tlfQNMIPMFCKALQLSLGVVAdl----rdGEAVDG---------------MDRELEFASSKvNPgaigangifss---- 1127 Phaeodactylu...
EEY54952       974 AAMTQIFAAIHQSMRASLAVV---------GDATSGagdkE----------LSASFAGVVGEvSAvaktsssalrvdc-- 1032 Phytophthora...
14_pfamImport    1 RAMKQVFAAIHQSMGASLAVV---------GDATSGagdeN----------LSASFAGVVGEvSTvaetsssalrvdc-- 59  
XP_001469145  1309 lACTNLLQCCCLVLRTCSSLVGtetvtagaTASSVAdevvDcrghvydrsrPEAESAM---------------------- 1366 Leishmania i...
Q38DI9        1135 ESCNQMLLCCNQALQNCSLLVGge----asGSANEGdvdvDcrghafdkgnPCEEASM---------------------- 1188 Trypanosoma ...
EGD77906      1112 GLLSRVVDVSTQAAEFCLSLLT--------TGVSDDt-------------rAMPSFQDMGTSlTQivrdqg--------- 1161 Salpingoeca ...
Q9VB48         636 tpledllplleRILSGILKFLNvanarrqeEAATAA----------------------SFQD-MDe-------------- 678  fruit fly
XP_001955346   645 qpledLLPILDRILKGVLQFLNlantrrkaEATTAA----------------------SFQD-MDe-------------- 687  Drosophila a...
XP_004366355  1122 yddderlassfatlsaqtsiedileqigntagaagggENedddneevdekpQEQktSAavdilkgstgQIITVCAWLSMK 1201 Cavenderia f...
EGR31610       585 --------------------------qqneqdqdeneEK------------SE---------------NLLVVAFYLISR 611  Ichthyophthi...
XP_002183914  1128 --------------------------vqrlsktehsrRL------------AS---------------QRIVIGSWLLTK 1154 Phaeodactylu...
EEY54952      1033 -------------------------rghlivengdglEEed--------gnAE---------------QRAVVGSWLAAR 1064 Phytophthora...
14_pfamImport   60 ------------------------rghlivedggdhgDDdg--------gnTE---------------QRAVVGSWLAVR 92  
XP_001469145  1367 --------------------------------------------------------------------RGVVNNTWLSMR 1378 Leishmania i...
Q38DI9        1189 --------------------------------------------------------------------RAVVNNTWLCIR 1200 Trypanosoma ...
EGD77906      1162 --------------------------------gdvqrDF-----------------------------PFMLSFMWLNIR 1180 Salpingoeca ...
Q9VB48         679 ------------------------------------sLQllv------sesSFKcdGEeea-----crKYLLMSFWLTLK 711  fruit fly
XP_001955346   688 ------------------------------------sLQllv------sesSFKsgDDdea-----crKYLLMSFWLTLK 720  Drosophila a...
XP_004366355  1202 ELSLLLGAILDGVSFPAKTAAEDSnnsssnnieLISVQqI-KDIGSAFLHILLNTRHKGAIEKAYLGFEILCSRLMGTTH 1280 Cavenderia f...
EGR31610       612 EAGFLFQTISNIVKEFQEQQIEKI---------LEKKE-L-ENLVNEFFIALINIKHLGSIDRIQIGLGMLCRTMNESKN 680  Ichthyophthi...
XP_002183914  1155 ETCAAVSILLSLGCVNPSKES------------------M-QQVGMLLISTLTSLKHTGAAFAAHKALQQISVACFSIPN 1215 Phaeodactylu...
EEY54952      1065 ECGAILELLMRRVPLPSSNSTSDSv-------tFFTAE-MaQRGGETLLNSLFELKHKGAVATAYQAFEGVCRAFLAHGE 1136 Phytophthora...
14_pfamImport   93 ECGAIMELLMRRVPLPTSNPTSASv-------sLFTVD-MaQLGGETLLNSLFELKHKGAVATVYHAFEGVCRAFLAHGE 164 
XP_001469145  1379 VAAGSITRLLKVRPVHAMPFA------------------AvHAAAYELVHALLLTKHNGVMRCVREALKALVATLVRSRQ 1440 Leishmania i...
Q38DI9        1201 TAAAAVERVVALVSIDSLDFK------------------VvRGVCYVLVESLLRTKHNGVMRAVRGALKTIAAALLRSRD 1262 Trypanosoma ...
EGD77906      1181 TACRSLASVAVIAARAPPKAAGSAvd-----------aaAiTAIKEKMCLVLKRCRHRGVIESTALSLTTVAQHLMQSKR 1249 Salpingoeca ...
Q9VB48         712 GCCDLATSIGCYQLQTSAKTVNTEt--------------L-RRCLNINVSVLTLCRHKGAIEAAGLSIGRLTRAITSSLD 776  fruit fly
XP_001955346   721 GCCDVATTIGCILLETFQKTVNCAa--------------L-SRCLDINVSVLTLCRHKGAIEAAGLSIGRLTRSITSILD 785  Drosophila a...
XP_004366355  1281 PE--LYT-LPSS---WIDQLF--RRVR----EQSLNITRRSAGLPYTFTGLLAGESHH----QKrmigplLNQ-VLQSLL 1343 Cavenderia f...
EGR31610       681 PI------LPQLssdLLQQLL--DNIEn---NTFKNVLRRSAGLPSAVVCLLKAEIAGnrq-------vlLNK-TVKRLL 741  Ichthyophthi...
XP_002183914  1216 -----LEtLPKE---WALRLL--DELAns-dKIRDSTLRRSTGYGLGFLSIMRSEVAChsanHS------LCSfIMKKIL 1278 Phaeodactylu...
EEY54952      1137 -QslVLGgLPAR---WADRLL--ERLEr---SEQHFILRRSSGFAFSFVAILRAEPRNsaavI-------LPK-VMSTLL 1199 Phytophthora...
14_pfamImport  165 -QsaVLGnLPAQ---WADRLL--DRLEr---SEQHFILRRSSGFAFSFVAILRAEPRNsaavI-------LPK-VMLTLL 227 
XP_001469145  1441 t---LFYqLPAE---LLDYLMgpEGVTs---GHVTRILRRSQGLPHAILAVLEAEDTTvp--------ycLFPsAMRQLL 1503 Leishmania i...
Q38DI9        1263 v---TCHtLPSE---ILEFLLgpDGVTs---VSVARMLRRSQGLPHALLAVLEAEDIGvp--------atLFPqAMKRLL 1325 Trypanosoma ...
EGD77906      1250 AD---LRpLPQQ---WLAAEI--ALLEtdseLETLSVTRRSAGLPHVVHSLALARKKGsr---------mLHP-HLEKLI 1311 Salpingoeca ...
Q9VB48         777 SCdsGFQmLHDC---LERELL--TE------SRQVSTTRRGAGFAIMFLHVLKNDNPRqr--------llLHR-AVQQIL 836  fruit fly
XP_001955346   786 SSdaGFQlLHEC---LERELL--AD------SRQVSTTRRGAGFAIMFLHVLKNDNPQqr--------lvLHK-AVQQIL 845  Drosophila a...
XP_004366355  1344 KLANGEEgtv---------------------------pspQDDGSIAPeqwaeRNIYLPQVH-SINILRSIFRNSSITNE 1395 Cavenderia f...
EGR31610       742 EMVQN-------------------------------------P----------NLVNNIKIH-SLNILKKIFEDGNIKME 773  Ichthyophthi...
XP_002183914  1279 CLSLPSKsmlssflssiawfdrerpiplpfslgdevdgigLCN----------QYTLRSRVH-ALNVLRSILSDAPLAKQ 1347 Phaeodactylu...
EEY54952      1200 RLAGED----------------------------------TDAAERRDthqehHSLWRARVH-ALNILKLICQDGVLAED 1244 Phytophthora...
14_pfamImport  228 RLAGND----------------------------------TDAVDKCEtheehHSQWRARVH-ALNILKLICQDGVLAED 272 
XP_001469145  1504 RVARGDIaga----------------------------haLGGAETAPlgvsaETVRRSQRSnALNVMKFIFEDKVFADR 1555 Leishmania i...
Q38DI9        1326 HVATNAHsnegg-----------------------pdlcpPNGNDERRtpeadGEIRRSQRSnALNVLKFIFENKSFASR 1382 Trypanosoma ...
EGD77906      1312 ALAGV-------------------------------------QPSSDThassaETQDMRQVH-CFNVLKVLFAESLLNSD 1353 Salpingoeca ...
Q9VB48         837 KRLN--------------------------------------ENQTAEtvcldSNHDRWEAL-VLHYLCVLVRDTELRPA 877  fruit fly
XP_001955346   846 KRLN----------------------------------------SVTGaaptdSNHDRWESL-ALHYLCVLVRDTELRPS 884  Drosophila a...
XP_004366355  1396 VDSYFAQTLITIIKAYSSKSWS 1417 Cavenderia fasciculata
EGR31610       774 VDKHMGEGFEIAIKGFSIEDWS 795  Ichthyophthirius multifiliis
XP_002183914  1348 VFPAVGDSIVTAMMGYSDTDWS 1369 Phaeodactylum tricornutum CCAP 1055/1
EEY54952      1245 VARYVVDMFELAVRGFDCGSWA 1266 Phytophthora infestans T30-4
14_pfamImport  273 VACYVVDMFQLSVRGFECGSWA 294 
XP_001469145  1556 VVAYIEEAFSLATEGFHDASWy 1577 Leishmania infantum JPCM5
Q38DI9        1383 SVSHLEDAFWIAASGFDDPSWg 1404 Trypanosoma brucei
EGD77906      1354 TQQYVSPAMVLAIRGFSSPVWS 1375 Salpingoeca rosetta
Q9VB48         878 MSKYYNEILLVAMEHITNPEWT 899  fruit fly
XP_001955346   885 MCKYYNEILLVAMEHIHNPEWT 906  Drosophila ananassae
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