Conserved Protein Domain Family
Q_salvage

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pfam10343: Q_salvage 
Potential Queuosine, Q, salvage protein family
Q_salvage proteins occur in most Eukarya as well as in a few bacteria possible via horizontal gene-transfer. Queuosine (Q) is a chemical modification found at the wobble position of tRNAs that have GUN anticodons. Most bacteria synthesize queuosine de novo, whereas eukaryotes rely solely on salvaging this essential component from the environment or the gut flora. The exact enzymatic function of the domain has yet to be determined, but structural similarity with DNA glycosidases suggests a ribonucleoside hydrolase role.
Statistics
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PSSM-Id: 402109
View PSSM: pfam10343
Aligned: 115 rows
Threshold Bit Score: 252.815
Threshold Setting Gi: 347591157
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKM79219      90 SHPLt--RTALDWIFLISSLNFSFWSLHegKKERYGVEWFTgweeakkntkgerQVHTGYWSLVASLNRALWEeDIPFVD 167 Agaricus bispor...
XP_015786129  55 LHPKeptDFAVNWIFLVDSLNFSFWPD---EDKEFGVTYKD-------------IEYTGYWALCAIINRALDQ-GIPMCN 117 two-spotted spi...
XP_015793048  54 LNPGisnEFAINWIFLVNSINFSYWPD---PDQEFAVTYKQ-------------AEYTGYWAICAIINRALNQ-GIPMVS 116 two-spotted spi...
ESO09264      58 LLPQtqdEFAANWIFLSDLLNFCFWSS---PGKEYMVHYKS-------------KNRTGYWSLCAALWRALDD-GYDITN 120 Helobdella robusta
NP_001025632  55 LNPQdsgEDAVNWVFFVDTLNFSFWSES--EENKYLVKYKG-------------KEYSGYWSLCAAMNRALDE-GIPLTT 118 tropical clawed...
4_pfamImport   1 LNPRaasEEAVSWVFLVDTLNFSFWSDS--AEQKCLVRYKG-------------KAYSGYWALCAAVNRALDD-GIPITS 64 
1_pfamImport   1 LHPNfadDAAIDFIFAVDTLNFCFWSDD--PEETYKVKYKD-------------TFYSGYWSIVAALKRAEDE-GKPVFS 64 
XP_002129448  61 LHPDvanETAIDFIFAVDTLNFSFWSDN--PEEKYKVKYKG-------------EFYSGYWSIVAALKRAEDE-GRPVFS 124 vase tunicate
XP_789899     55 LHPKtttDATVDWIFVLDTLNFSFWSET--NDKRYLVRYNN-------------ENHSGYWALCAALMRACDE-GIPITS 118 purple sea urchin
A7SNN9        55 LHPKemsKATVDWIFVLDTLNFSFWVDD--GLEPWTIRHKG-------------KDFQGYWALCAGINRAIEE-GIHLTS 118 starlet sea ane...
EKM79219     168 PNFYSSETMcpdSLIEHVFRPV-HHstEL---LPLIHERIRI-MREVGSILCNsfggSFKGFLDEFHRRhhRQGSALDLV 242 Agaricus bispor...
XP_015786129 118 PDYYSNLSL---DQVKRIFAAHrKGkpNEpmdLPLLEERHAI-MRENGSVLVK----KFSNTFVSMVIK--AKNSAKTLL 187 two-spotted spi...
XP_015793048 117 PEYYSNLSY---DQVQRIFRAHkKGkpNEpmeLPLLKERANI-MKDNGKILVK----KFSSNFVTVVVK--AKKSARSLL 186 two-spotted spi...
ESO09264     121 PAFYSKIDE---STLKKIFRSD-SN--YD---IPKLHERHCImLKD-GEILLK----NFNGSFLNVVKA--CNNSAENLV 184 Helobdella robusta
NP_001025632 119 ASYYSSLTL---EQLKHILRSD-SE--TP---IPMIEERLEI-LHQTGKILME----KFGGSFLNCVQM--SQNSAVKLM 182 tropical clawed...
4_pfamImport  65 ASYYATMTL---DQVRHVFRSD-TE--VP---MPLLEERHQV-LNESGTVLLE----KFGGSFFTCVKM--SENRAQKLL 128
1_pfamImport  65 AIFMSSVDL---DEFKHIVRSD-TI--VE---IPLLKERLKA-YNEAGRVLLE----KYDGSFSNCIRR--CNKDAVQLV 128
XP_002129448 125 AKYMSSVEK---DEFAHILRSD-SS--VQ---ISLLEERLHA-FNEAGQVLLG----KYDGSFSNCIRS--CNKDAVQLV 188 vase tunicate
XP_789899    119 PSYYSKVTL---DELRHVFRSE-TD--TG---IHLLDKRIEN-LHQTGKVLME----KFDGSFVNCIKS--CENSAVKLI 182 purple sea urchin
A7SNN9       119 PSYYRNITI---DDLKHIFRSE-TS--TE---MPLLEERAKN-LRETGNILAQ----TFQNSFAHMILL--ANKSAKLLL 182 starlet sea ane...
EKM79219     243 KLVVETFPTFRDQVWYQGRPVYFWKRAQILVAELWAAFYP-ETpSFPhplFPghsgHrIHQLTMFADYRVPQILHHLRIL 321 Agaricus bispor...
XP_015786129 188 KMVHEYFPSFRDELLYNGESIGFYKRAQLLIGDIYACHEG-KG-LGK---FD----D-IQDITMFADYRVPQCLYYLGVI 257 two-spotted spi...
XP_015793048 187 QLIYENFPSFRDECVFNKERVGFYRRAQLLISDIYACHEG-KN-LGK---FD----D-IDYLTLLVDQRAPQYLHFCNVL 256 two-spotted spi...
ESO09264     185 NLITKEFTSFTDQINFQNVEVSFYKRAQILVADIWSCFGG-KG-YGR---FH----D-IDTITAFADYRVPQVLNWFGAL 254 Helobdella robusta
NP_001025632 183 QLVVDNFPSYRDEGCFKGKKVAFYKRAQILVGDTWGVLEG-KG-DGC---FY----D-IQNMTMFADYRIPQALAHFGAM 252 tropical clawed...
4_pfamImport 129 HLVVENFPSYRDEAVLRDQSICFSKVFHYLIEEMYNSLEGkKG-DGF---FG----D-ISSLTIFADYRIPQVLVHLKAM 199
1_pfamImport 129 NILAADFSSYRDESVFDGRPIALYKRAQIAVADIWLCFEG-RG-LGE---FS----N-IDKLTMFADYRVPQTLEYFGIL 198
XP_002129448 189 KRIAADFGSFRDEAVFDDQPVAFYKRAQIAVADIWLCFEG-QG-LGE---FR----N-IDQLTMFADYRVPQTLEYFGIL 258 vase tunicate
XP_789899    183 ELVTSHFSSFRDVATFNGTAVSLYKRAQILVADIWACFEG-QG-HGC---FT----D-IDTLTMFADYRVPQGLNYFGVL 252 purple sea urchin
A7SNN9       183 SMVINNFDCFRDDGDFCNQKVSFYKRAQILIADTWACFEG-KG-FGE---FP----D-IDFLTMFADYKVPQGLYDLGVL 252 starlet sea ane...
EKM79219     322 EYPSSLMRLLR-SGIDLAPGCREEVSLRAASIIAVERLREEIVSAPECGTlvQsn-----deEVSSVLIDFYLWDLA-K- 393 Agaricus bispor...
XP_015786129 258 NYRDELLRRLS-AGEKFKYGDPDEVEIRGVSIHAVEQIKNGVVRLAEINNvtLp-------iPATSVIVDFYLWDLR-R- 327 two-spotted spi...
XP_015793048 257 SYSLELRKKLK-LGEVLKYDDPDVIEMRGVAIHAYELIKREVKRMQVRCGvkLp-------lPLTPTIMEFYFWDLE-R- 326 two-spotted spi...
ESO09264     255 KYSEELTSLLKkEGTTFAHGDRWEIEIRGCTIHCIELIVKKVNETLESLPssTtn------lKVNSIIIDHYLWDMR-R- 326 Helobdella robusta
NP_001025632 253 KYSEELLKQLK-EGWLFRNGDVQEMEIRGCSIWAVELICEQLLRLFEKCGkqMs-------nEINPVLIDHFLWDYA-R- 322 tropical clawed...
4_pfamImport 200 KYSEDLMKKLR-EGTVFKSGDREEVEIRGCSIWCCMLICRHLLELYEKKGqdMr-------dQINAVLLDYYLWDYA-R- 269
1_pfamImport 199 QYSKELKEKLQ-NRETLQSGCRLESEIRGCSIEAVEKLKSETRKILLSNPetTky-----akIVNSITIDNHLWDFA-A- 270
XP_002129448 259 QYSKELKQKLD-GREVLLPGSRTEGEIRGCSIEAVERLKNETKKLLLSDKstTdv-----arIVNSITMDNYLWDYA-A- 330 vase tunicate
XP_789899    253 SYSDALKKRLEdETKLFTPGERLEVEIRGCSIWAVELILQEMRRIRGEDLkkGd-------vIVNSIIIDFYLWTYC-K- 323 purple sea urchin
A7SNN9       253 QFSEALKQKLV-TGQLIPHGDQLEMEIRGNSIWAVEKIYLAVKLKAKKSPefSnmdslelaqYLNSVIIDFYLWDFSkNv 331 starlet sea ane...
EKM79219     394 RIENGEekvegiktaELAPIHRTRSIWY 421 Agaricus bisporus var. burnettii JB137-S8
XP_015786129 328 SRPDEId--------ECITYHKTRSIHY 347 two-spotted spider mite
XP_015793048 327 NRRDEId--------RQLPSHKIRAIHY 346 two-spotted spider mite
ESO09264     327 EKAKEL---------ESVPYHRTESIYY 345 Helobdella robusta
NP_001025632 323 DYRNEI---------NAVPFHRVRCIYY 341 tropical clawed frog
4_pfamImport 270 DHREDM---------KDIPFHRVRSIYY 288
1_pfamImport 271 SHRSKM---------AHLEFHRVRTIFY 289
XP_002129448 331 AHRAEM---------AHLMFHRVRTIFY 349 vase tunicate
XP_789899    324 DHRDVM---------AHIPIHKIRSIYY 342 purple sea urchin
A7SNN9       332 EARAS------------IPCHKTRTIFY 347 starlet sea anemone
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