Conserved Protein Domain Family
7TM_GPCR_Srx

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pfam10328: 7TM_GPCR_Srx 
Serpentine type 7TM GPCR chemoreceptor Srx
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Statistics
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PSSM-Id: 402100
View PSSM: pfam10328
Aligned: 79 rows
Threshold Bit Score: 121.555
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KHN78938      26 FIVAVVGIVTNGMSAFTIFKMEHLRNAFGYSCASHAFGNLGVLFIFAFWAAPLLILQHHLI--QEIHGYKflsdTAGQLT 103 dog roundworm
2_pfamImport   1 IMVALFGLISNGLSLYLTRTRSRFHNAFGILCSSFLICNLQAIFVLLIWCTVVLSLKSPILssPTIFLVR----FIGVLV 76 
VDO26022      18 IPIALLGLLAYAISLYLIHKSERYHNVFGILCTAYVSFHIQTVSVLFIWTIVRIIVHAGLK--PFPWTTFi--rIFSPIA 93  Brugia timori
EYC42246      66 FVVGVPGLYLNMLSTFSLFGAATP---FEMICACHAAGNAGVLAVLIFCSAPMIYFGSPWLnvSEFGK------MAGRVT 136 Ancylostoma cey...
EGT42613      12 FLVSLLGFIVNAFFFLKLTALQKTLNSFQKLCFVKGISNALICASIILWAVPLSAFSAKTEnvWRSWNIG----ISELTA 87  Caenorhabditis ...
P90819        12 FFVSLLGFSVNSYFVYKILSTRVAINSFQKLCFVKAFSNAVISLTIIVWAVPLSAFLIETNgfWRNVNVG----ISELVA 87  Caenorhabditis ...
CAP30497     185 FAISSIGLVCNFYFTIKFIFRKPHSNGFQRICTVKTMNNCIICSTFLFWVLPVTLLQFTYSelNYPANRI----ISGMAA 260 Caenorhabditis ...
OZG22001     330 FITSFLGTICNVFLLIKFATRSEKSNGFQKICLVKTIPNIIVCISFLLWAIPLTAFGYTYDevAYWINSL----VGGMA- 404 Caenorhabditis ...
EGT42650      11 FFVSVFGVSINIFLFFRFIKKDKSGG-FLTYCLAKTVPNTIVCSAFLFWVVPITGLALKYPevPRLINVI----VGQLAG 85  Caenorhabditis ...
NP_506426     47 FQTSLLGSICNIYLLLKFSARDGRPNGFQKICLVKTVPNIIVCLSFLFWVVPLTAFSYSYNevNYWLNSL----VGGVAG 122 Caenorhabditis ...
KHN78938     104 IVFYYAGIYTNILITMNRCFIITWPALYQKYFNTSMTLRWIVLIWTIAFIQsCi--YQFPGCHFYFD-SQSYTWTYSaSE 180 dog roundworm
2_pfamImport  77 NGAWFGSVLVHFFTALNRFCAFVFATKYNQLWSGSKALFVGISSWTFGVFL-Si-qHLYEECSFVFNqNSNYRFSYQ-NS 153
VDO26022      94 NSTLYAAIWIQFVLAINRLWAISYPMTYHRIFSRKNARLAVVFLWSFSML--ImvlYYNVECVRYFE-SDIYSWSTLyGP 170 Brugia timori
EYC42246     137 MYAWFLIHYTQVLLAINRFMAINCYMIYNKVFSSANTKKILAVLGIYLLW--YffvGFFDGCHFIFL-STTWQWAFEqTQ 213 Ancylostoma cey...
EGT42613      88 SGGYIFGPLCQILMAANRVIVLYCPLFRMRMERVPSTNISIFVCVLVSLY--CsiaGMQGPCVLIYH-PETLAWSPElST 164 Caenorhabditis ...
P90819        88 SGGYIFGPLCQILMAANRVIIMYFPFWRMKISRFPSTNVAVFVCAFVSLY--CsvaGMRGPCVLTYH-PDTLAWSPElST 164 Caenorhabditis ...
CAP30497     261 LWAYVLNSLLQVCLACNRLYGLYFPLGIAIWKTVPMANMAIAISVTLTSML-SfvsI-PVGCGYIYD-PNLFVWRTEfHD 337 Caenorhabditis ...
OZG22001     405 ------APILQVSMSCNRFYVLYFPFGMKPVKKLPMTSLAIVFAIISVTIV-TmftM-PKGCGYVYD-PEYFQWIPEdDE 475 Caenorhabditis ...
EGT42650      86 FGAYVGGALIEMFMAINRCSVIYVPS-----FNFKNANYVITFVFMVSMVY-VligIVPASCGFVFD-PETFLWRPEeTP 158 Caenorhabditis ...
NP_506426    123 TWAYLLTPILQVSMSCNRFYVLYFPFGIKLVKKVPMTNVIITIASLSVSIV-AattL-PKGCGYVYD-PEFLQWIPEeGK 199 Caenorhabditis ...
KHN78938     181 CGYAISTFFECSLNSFAVIFIISMDSFIFYRLRcMHKALLIsGSNAISvteqQQRRKREIRFFLQACCSESLYLFAVANF 260 dog roundworm
2_pfamImport 154 FYGKICALADTTATVGLLMGMAFIDLATLVKIIaYRRTMQNnTTISTG----NIIYEREVLFFKQSCILGLLYISCTAMF 229
VDO26022     171 CNHSFFIYFSILLSDGIILITVMVDAIAFYRIV-AYIKKKKhQEVNAT----RGSLSHDILFFKEKIFQACITTGIHAFL 245 Brugia timori
EYC42246     214 CGLILFIYVDFYFTIGLLITSLAFDFCTAISIY----RFVK-ITASTD----RHFGHTDVMFFIQSCMSNFIFIADLSLF 284 Ancylostoma cey...
EGT42613     165 CIDSMDGLQ-LATIIILTFIAILFNVLAVFKLI-YDKVSGI-TDTQK-----SRRRKRWLAMFIQNVIQDALHVIDMINY 236 Caenorhabditis ...
P90819       165 CTDSMDGLQ-LPIIILLTMVSIIFNFIAAFKLI-YDKVAGIsDVQKL------KRRNKWLLNFIQNVIQDALHVIDMINY 236 Caenorhabditis ...
CAP30497     338 CSKRLAVIF-PFVILGTTIATNAFNVAIGTRLL-AMKLIG--VKEEEA----KERRRRWMVMFIQCVLQDCLQLFDTINS 409 Caenorhabditis ...
OZG22001     476 CAANFASGI-MFAIFAITLVSNSFNVATAARLL-FSKMVG--MTKKDS----SRRRRRWMIMFLQSVMTDCLHLVDIINA 547 Caenorhabditis ...
EGT42650     159 CAVLMEDII-LFTIYGTFAVSNSLNLVTFVKLC-FGKVEG--ISSSEI----MRRRKRRIKFFVQSVIQNCLHIIDMINF 230 Caenorhabditis ...
NP_506426    200 CAETVSSGI-NYAIIIFTISSNSFNIATASRLL-MRKIVG--LTKQDS----SKRRKRWMIMFLQSVMQDCLHLVDSINA 271 Caenorhabditis ...
KHN78938     261 YGFVQ-LSr------SKWA-TFILTTMVWELFHTVDGIILVAFN 296 dog roundworm
2_pfamImport 230 NTAPYlFM-------NRWF-LFASSTITWILTQSLDGLIFLMFN 265
VDO26022     246 IAIFR-ID-------GPFIaRVTKVTYMWLAMSTLDSFTFIFFN 281 Brugia timori
EYC42246     285 LVGPTiYQallgeapDTFG-IFLINTLSMEISHFLDGLIMVVFN 327 Ancylostoma ceylanicum
EGT42613     237 SVLDK-LVe------GEGF-HFIFMSLSFALIYVLDGIVMLRFH 272 Caenorhabditis brenneri
P90819       237 TFIYK-LKd------AEWF-QFIFLSLSFALIYALDGLVMTHFH 272 Caenorhabditis elegans
CAP30497     410 YYIVL-LSe------KVWF-QFLFVTLSLVFIATMDGVVMLACN 445 Caenorhabditis briggsae
OZG22001     548 TYIYK-LNd------ELWF-QFIFLTMSFILIYTLDGFVMLIFN 583 Caenorhabditis latens
EGT42650     231 NFISN-LNd------STWF-KFIFTSMSLLTIHALDGFVMFIFH 266 Caenorhabditis brenneri
NP_506426    272 TYLWK-LSe------ELWF-QCIFLTLSFITIYTLDGFVMLVFN 307 Caenorhabditis elegans
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