Conserved Protein Domain Family
CTU2

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pfam10288: CTU2 
Cytoplasmic tRNA 2-thiolation protein 2
CTU2 is a family of proteins necessary for the formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae. The family is conserved from plants to humans ]1]. It plays a central role in the 2-thiolation of 5-methoxycarbonylmethyl-2-thiouridine, or the wobble nucleoside. This wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U), is required for the proper decoding of NNR codons in eukaryotes. The 2-thio group gives rigidity by largely fixing the C3'-endo ribose puckering, ensuring stable and accurate codon-anticodon pairing.
Statistics
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PSSM-Id: 402073
View PSSM: pfam10288
Aligned: 102 rows
Threshold Bit Score: 58.9646
Threshold Setting Gi: 159105567
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBQ71059     423 SIARLTETFILNLEKGVPSTVTTIGKTGSKLVLNAPSSeaqgessastsashstsafqnvgpsvalrsraavsdkmasms 502  Sporisorium re...
EFN85786     244 SIQALTYNFTMALESQFSGTISTIMRTAEKLSARNNQNnq---------------------------------------- 283  Jerdon's jumpi...
EGI66815     259 SIQALARNFTMELESQFSGTISTVYRTADKISPRSNVQq----------------------------------------- 297  Panamanian lea...
EFN66916     766 SIQALAHNFTADLESQFSGTISTIFRTAEKISPRINSQq----------------------------------------- 804  Florida carpen...
XP_005592838 316 SIHRLMEAFILRLQTQFPSTVSTVYRTSEKLVKAPRDGpaa--------------------------------------- 356  crab-eating ma...
Q3U308       347 SIHRLMEAFILRLQTLFPSTVSTVYRTSEKLVKA---Pregc-------------------------------------- 385  house mouse
EGV94077     253 SIHRLMEAFILRLQTLFPSTVSTVYRTSEKLVKA---Prdsc-------------------------------------- 291  Chinese hamster
XP_850047    339 SIHRLMEGFLLRLQAQFPSTVSTVYRTSEKLVKA---Prdg--------------------------------------- 376  dog
XP_019659047 258 SIHRLMEGFLLRLQAQFPSTVSTVYRTSEKLVKA---Prdg--------------------------------------- 295  giant panda
XP_023363269 321 SIHRLMEAFLLRLQTQFPSTVSTVYRTSEKLAKA---Prdsh-------------------------------------- 359  small-eared ga...
CBQ71059     503 iadaseprigsrgiklaqtsascfhwnTASGCALCGMPSrHPQARHWKRDITISSLAETAPSQQ---------------- 566  Sporisorium re...
EFN85786     284 --------------------------dMEDNCVLCDAGL-NSVSSDNVTAMKAIEVSRLVSSDAkdirif--------ir 328  Jerdon's jumpi...
EGI66815     298 --------------------------sLENNCALCDARLdFVPSGNEVTAMRAIEVSKLMSSKCid-------------- 337  Panamanian lea...
EFN66916     805 --------------------------nAEDNCVLCDARLdATSSTEEVSAMRAIEVSKLMSSNie--------------- 843  Florida carpen...
XP_005592838 357 -------------------------gdSSPCCLLCMCAL--DVDAADSATAFGAQTSRLSQMQSptpltetrtppgpccs 409  crab-eating ma...
Q3U308       386 -----------------------aagpSGPSCLLCMCAL--DIDTADSATAFGAQSSSHLSQM----------------- 423  house mouse
EGV94077     292 -----------------------atgpSGPNCLLCMCTL--DIDTADSATAFGAQSSSHLSQM----------------- 329  Chinese hamster
XP_850047    377 -------------------------caAGPRCLLCMCSL--DVDTADSATAFGAQTQ-DFSQTQpp-------------- 414  dog
XP_019659047 296 -------------------------caAGPRCLLCMCLL--DVDTADSATAFGAQTQ-DCSQMRpp-------------- 333  giant panda
XP_023363269 360 -----------------------dtahSEPRCLLCLCTL--DVDGADSATAFGAQTSSHLSQMQph-------------- 400  small-eared ga...
CBQ71059     567 ---PTRGSGTNGSEGEWIELSDH---------------------------------LCYACLL 593  Sporisorium reilianum SRZ2
EFN85786     329 teeKESFNDKKSVRTNLCLPTNAeccnnsgsrcdyvg-----nkigqltvedvqrcLCYSCKL 386  Jerdon's jumping ant
EGI66815     338 --tISSNNEENGKTNYLFTHSDNngccndnvncncen-----nrerqvttedvwrhLCYSCRq 393  Panamanian leafcutter ant
EFN66916     844 --iKTSNDKENEKSNYTSLCLEDkiycnnntecckn-------nktkitaedvwryLCYSCRL 897  Florida carpenter ant
XP_005592838 410 pgvGRVQGCGQGACRREDPQACIee------------------------------qLCYSCRV 442  crab-eating macaque
Q3U308       424 ---PSA-----------EAGMPTqpccaagegqaqschr--evgkrgdaraciteqLCYSCRV 470  house mouse
EGV94077     330 ---LPA-----------EAGMPTppncgagegqaqschr--gvgrredvqacimeqLCYGCRV 376  Chinese hamster
XP_850047    415 --tPLA-----------EAGAAPmpccsaevgraqkccq--stllcrredsqvieqLCYGCRV 462  dog
XP_019659047 334 --tPPA-----------E--APTvpccstevgrvqncfrgtkpcgredsrarvieqLCYSCRV 381  giant panda
XP_023363269 401 --tALA-----------EAGMHPvpccppevgsaqgccr--gpcergdprvcvlewLCYGCRV 448  small-eared galago
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