Conserved Protein Domain Family
Frag1

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pfam10277: Frag1 
Frag1/DRAM/Sfk1 family
This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localization of Stt4p to the actin cytoskeleton.
Statistics
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PSSM-Id: 402067
View PSSM: pfam10277
Aligned: 65 rows
Threshold Bit Score: 84.2265
Threshold Setting Gi: 121890698
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001644391   12 YFFIVPWIAFIPWWGMLIAMLACWAGQGhPI-YWfmng----dqfPVYISD-IGATNLQPLFISCSGWQGLGYVISIACE 85   Vanderwaltozy...
XP_003721983  115 PSSYAALIYALTTGYALFACLYMAGVLH-WRdIIvtscgedhyefWPSISAtVGEMMPERQTWRVAFTLCVPFRVSASMS 193  Leishmania ma...
Q54J51          6 SASLLPLSYGIIAMGSFITTLFLACYLH-FErVTknhck--myefLPSISStIGDFSPEMNVYRYGMALTSGLRLGTIYL 82   Dictyostelium...
Q9HDZ2         11 SAQYVALVHTICSFAAFFIPLALALYTH-YYqVVknefygypeewFPSVSAtIGDWYPERSVFQWLIALTATPRLLVLLL 89   Schizosacchar...
Q6C3N0         30 NGKYVGWAHTIVAMSAFLGALIIGCALH-YKkIVqnehfgypdewFPSVSAaIGDRYPERSVFQVFIAITSGPRFALVIL 108  Yarrowia lipo...
XP_001270970   15 NGKWVSWTHTIVAYTAFLSALVVGMSLH-FHkIVqnehygypqewFPSVSAtIGDRYPERSFFQVFIAITSGPRFALVFL 93   Aspergillus c...
Q757Q5          5 NGKHIVHLHSLFASSAFICALVVGYQLH-FHkIVrnahygypdewFPSVSAtIGDRYPERSLFQVLIAVTAFPRFLLLLM 83   Eremothecium ...
XP_001527655   32 NAKWISFAHTFLASLSFLAALVVGVYLH-YHkIVenasfgypdewMPSVSAtIGDRYPERNVFQIIIALTAGPRFALLAL 110  Lodderomyces ...
EDK36219       21 NGSWVAYAHAFFAYSAFFAALIVGCWLH-YHkIVknasfgypdewFPSVSAtIGDRYPERSLFQVLIAVTSGPRFLLLAL 99   Meyerozyma gu...
XP_009853772   18 NGQWISWTHTVVAYAAFLSALIIGCALH-YHkIVknewygypdewFPSVSAtIGDRYPERSIFMIFIAITSGPRFALVGL 96   Neurospora te...
XP_001644391   86 FFQRsghwpfrlrskkylkstvdedcdtmmtndemkseyaeimlksnfyMPPWYTVHDRn------------------FI 147  Vanderwaltozy...
XP_003721983  194 LFNV---------------------------------------------FWQRASRGMEdlysfrrsw-kaflssnafLA 227  Leishmania ma...
Q54J51         83 NHHVst-----------------------------------------eeKNNLLAQSNSgrksftsssvlesvrrlgyLI 121  Dictyostelium...
Q9HDZ2         90 WFTL---------------------------------------------SGISRP-----------------------SV 101  Schizosacchar...
Q6C3N0        109 WFLL---------------------------------------------TVAHRPR----------------------LS 121  Yarrowia lipo...
XP_001270970   94 WYIL---------------------------------------------TARPNST----------------------LP 106  Aspergillus c...
Q757Q5         84 HWVR---------------------------------------------S----------------------------RS 90   Eremothecium ...
XP_001527655  111 NFIT---------------------------------------------LYKQSSY----------------------LP 123  Lodderomyces ...
EDK36219      100 NYFI---------------------------------------------CAENGPL----------------------LA 112  Meyerozyma gu...
XP_009853772   97 WYLL---------------------------------------------TAKPGRV----------------------LP 109  Neurospora te...
XP_001644391  148 FAAFIFGLLGEVCLLMASIFSTAHYHHVHIAMVVLFVILMFISVCCLIAEYASMGkHYallhplanpettipferlrwyq 227  Vanderwaltozy...
XP_003721983  228 LLALGTDTWRFIGASVYSVVSAKESLTYHNLGICPYLPFCLVLQAAVTMLVRRNQfNTaiy------------------- 288  Leishmania ma...
Q54J51        122 PMSTVFDTIRVFSAGGWIYISSSEHLFSHQVGFVSYVIFSFLYMYTHCAVLYHTKiKFragfenqsiss------iifkg 195  Dictyostelium...
Q9HDZ2        102 IITTALGVLRTALCGGWVYVTSTDDHDWHDIFMIGYLISNAPWFILVSKCS----------------------------- 152  Schizosacchar...
Q6C3N0        122 MMILISGLMRTLTCGGWTYVTSTDDHDWHDIFMISYMVLTIPWTVGCTLCT----------------------------- 172  Yarrowia lipo...
XP_001270970  107 KVVAGVGLFRTFTCGGWTYVTSTDDHDWHDIFMISYLVATLPWTLGCLALS----------------------------- 157  Aspergillus c...
Q757Q5         91 ALGVMAGFTRTMTCGGWVYITSSDDHDAHDVFMIAYIVLTIPWCVFVVR------------------------------- 139  Eremothecium ...
XP_001527655  124 YIGLIAGLLRTFTAGGWMYITSTDDHDAHDVFMISYMVLTIPWTVCTTLLS----------------------------- 174  Lodderomyces ...
EDK36219      113 TIGVVCGIMRTFTCGGWVYITSTDDHDWHDIFMIAYILLTIPWTVCMSVLS----------------------------- 163  Meyerozyma gu...
XP_009853772  110 KAIAISGVIRTLTCGGWTYITSTDDHDWHDILMILYIVFTIPWTTGCIALS----------------------------- 160  Neurospora te...
XP_001644391  228 wsghiWNKFTLSAAFKAVWLTLGVVWAICFGACGD-----------SISACFEWLLAFWFGLLFISISVDFYLG 290  Vanderwaltozyma pol...
XP_003721983  289 ---ptPQDATASYAVKRVCLCVEVVAAVGIVCCYShylrtcangslSLSSICEWVFSIFNIIFDGSAWFDLKQE 359  Leishmania major st...
Q54J51        196 nyspkTQKDLFSFKWKAILGIAHFLLFVGSLKYFVdhtfycvylsySKYSIFEWLLATTNILYDTLTYLDFDGL 269  Dictyostelium disco...
Q9HDZ2        153 ------PVNSMASRIRNIGSALFVLTIFPLIYWYIqhkfkhipgayTVYAFFEWSLILWDILFDSALYWDFKPL 220  Schizosaccharomyces...
Q6C3N0        173 -------RDANARKWRKIVATCFFGSIPPLIYFFIqhkvhhiagayTTYAFLEWALVIFDVMFDAVTVLDFSAL 239  Yarrowia lipolytica
XP_001270970  158 ------PNNRRAVKYRKIMASLFFGTLVPLIYYFIqhkvhkvpgayTKYAFFEWSLILFDVGFDAVTALDFEAF 225  Aspergillus clavatu...
Q757Q5        140 -------HATHNRALRKVVGGAFFGTLVPLIYWFIqhnvkkragaySIYAYFEWSLIILDILFDGLSYADMEDL 206  Eremothecium gossypii
XP_001527655  175 ------PRHSFQRKARFYSAVGFFSTIVPLIYWFIqhkvhvragaySIYAYFEWGLIALDILFDSWSYIDFQTI 242  Lodderomyces elongi...
EDK36219      164 ------PKGSIVRRGRTWTAIAFFSTLVPLVYWFIqhkvhvrpgaySIYAYFEWALILLDVGFDTWSVVDFADI 231  Meyerozyma guillier...
XP_009853772  161 ------PPNAKAIKYRKWIAGSFFGTLVPLVYFFIqhkvhrvagayTVYAFFEWALILFDVAFDAVTALDFDTF 228  Neurospora tetraspe...
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