4DHJ


Conserved Protein Domain Family
Peptidase_C65

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pfam10275: Peptidase_C65 
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Peptidase C65 Otubain
This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumor domain) in which there is an active cysteine protease triad (ii) a nuclear localization signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.
Statistics
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PSSM-Id: 402065
View PSSM: pfam10275
Aligned: 21 rows
Threshold Bit Score: 206.368
Threshold Setting Gi: 124463467
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4DHJ_I    36 DEQKSVPL-VATL----APFSILCAEYDNetSAAFLSKA-----TELSEV--YGEIRYIRGDGNCFYRAILVGLIEIMLK 103 Caenorhabditis elegans
Q0V4T6    82 EPEATGPL-VGER----QSSAAITTEYQNa-DPIYRIKT-----AALPGK--YAFFRTCRGDGHCGWRAIAFTYFEALLR 148 Parastagonospora no...
EDN99907  20 QPALVGPL-VGDK----MRSTAITEEYAKa-DPIYVSKT-----SALPQK--YSHYRPILGDGNCGWRAAVFSYFETLLR 86  Sclerotinia sclerot...
Q2H586   170 APHTQGPL-VGKK----TPSSAIMEQYADa-DAIYVQKT-----MALPQT--YSDYRPIQGDGNCGWRAIGFGYFETLVK 236 Chaetomium globosum...
Q7SI56   234 yqpelnglpVGDK----LPSTAITEEYAKa-DPVYVQKT-----RSLPAV--YSHYRPMLGDGNCGWRAIGFGYFETLIK 301 Neurospora crassa
KIS69951  28 ESTSHQAL-ISAV----EPIEVLEKEYAA--NRAFLGKI-----KWLKEEagFIGLRRAKGDGDCFYRAFAFAFIYKIMM 95  Ustilago maydis 521
Q4DPS6    17 SEIESVPL-LSDPvealSETCSLVKEFAN--SASILPKVlslfaSDNDDR--YSGIRYARRDGNCFFRCVVFSLLESMLG 91  Trypanosoma cruzi
Q7XPN5   230 DSCKTRDK---------KPIVDLADEFE---NNTIKKKI-----TLLSEK--YDFFRPVDRDGSCFYRAFIFSYMERIVA 290 Japanese rice
Q5KB39    20 ENTSDKPL-VSTP----VPLSVIREEYLKg-SQQIVKKL-----DYLQENg-WDQVWRARGDGDCFYRSFTLAYLLRILH 87  Cryptococcus neofor...
A0E9B0    29 EIEAQDPFiITQP----IELQILESEYLQ--NQGFLQKI-----QKIRQS--YPQFRRVRRDGSCFYRAVLFRIFEYIIE 95  Paramecium tetraurelia
4DHJ_I   104 DRA------RLEKFIASSRDWTRTLV---ELGFPDWTCTDFCDFFIEFLEKIHSGVHTEE-----AVYTILNDDGSANYI 169 Caenorhabditis elegans
Q0V4T6   149 VGDv----nKFGDEEARLNSLGNLLD---HIGYSRDLWIDFADGAFDLMRKLADSLQAMDgqapdILLQTFNDFNESMSI 221 Parastagonospora no...
EDN99907  87 MGNr----gQVDEELARMMSLNNLLTt--AGGFDAWLFEDMVEETTSLLRDVADLMDTSIqaaesLILDRFNNSETSNAI 160 Sclerotinia sclerot...
Q2H586   237 SGSk----aRIEAERQRLEGLNSLIEn--VGEFSPYVSQDFVDETLALLSKMAALVGHREqa-mtELREAFNTPSISDSV 309 Chaetomium globosum...
Q7SI56   302 LGNk----aQVDGERERLESLNEYIQh--HGGFDPMVFVDFVEETDELLKRISDKLNVPEea-msEVMHAFTDAEKSNAI 374 Neurospora crassa
KIS69951  96 MKDr----pMHHFTVKHVESTLQLLK---HAGFDEEVVTDFYEPLKNLLNRMYSTDPESQelnehALLQAMNEPEQSNSI 168 Ustilago maydis 521
Q4DPS6    92 DNE------LTARYLEQATELRTKLI-----EDYGDFVEDFCDAAIAVIRQIESGGCTTS-----EELYALATSHDSEYV 155 Trypanosoma cruzi
Q7XPN5   291 MQDdleriiEVSRIGERIGKYKQAYArfgSFGIPQEEFLKALSAFEQLINLIEkgv-------avEQLYQIDETDITKNS 363 Japanese rice
Q5KB39    88 SPEpd---vEANLAYDAIQRALPAME---QCGFQKDIYEEFLDPLLALIRSFAESDETTAne--ySIVQALQDPERSNYI 159 Cryptococcus neofor...
A0E9B0    96 SKDq----qILDKFSTIIANSKADLT---AVGYEQIVIDDFYDEIMKQIKLCPNNITIQ------GIVDAFCNKVTSDYL 162 Paramecium tetraurelia
4DHJ_I   170 LMFFRLITSAFLKQNSEEYAPFIDEg--------MTVAQYCEQEIEPMWKDADHLAINSLIKAA----GTRVRIEYMD-- 235 Caenorhabditis elegans
Q0V4T6   222 ITYVKLLASAWVQTHADEFRHFVPM---------GDVKAYCANNIEPTKCEADNIGIAALAEALikpaGFGLEVWYLD-- 290 Parastagonospora no...
EDN99907 161 VYHCRLLASSWLKANPQNYQGFIPDg--------GGIDQYRKDWLEPPNQEIDHLGMTLLIDVLlkpaGFAVEIVYLD-- 230 Sclerotinia sclerot...
Q2H586   310 MYHFRMLASSYLKGHRETYSAFVTGg--------TGVDGYCLEVLERHNVEIDHLGLILLANVLlkdaGFVLEVAYLD-- 379 Chaetomium globosum...
Q7SI56   375 IYHLRLLASSWLKENRGSHEAFITTd--------ESVEKFCQRVIEVPNIEIDQLGLQALVSILlkpvGFVLRVAYLD-- 444 Neurospora crassa
KIS69951 169 VVYLRLLTSAFLKLNADEYTPFLFSldtssdagpPDMASFCANQVEAIGKEADHVQITALSRAL----KVSLDVAYLSpq 244 Ustilago maydis 521
Q4DPS6   156 IYFYRYAVSNYIRGHKDDFLPFVMGln------yENVEDFCRAEVDAVSSESDNVQVVAFARCF----QLKIVVEYLD-- 223 Trypanosoma cruzi
Q7XPN5   364 LRFLRFLTEIEICTHEDHYKGFLLTad------ySSVFEFCQVEVRPENAEASNEQMKALVEAL----GIPVLVENLDtt 433 Japanese rice
Q5KB39   160 VVSLRLITSSYIRTHADLFSPFLFSptt---flpLSTEEFCRQEVEPCGKEADNAQIMALAEAM----NAGVRVAYLD-- 230 Cryptococcus neofor...
A0E9B0   163 IMYMRMMTSGYIKANSFLFEGYIET---------GTVELFCQQEVDPIDREADQMQIIALQNYL----QIPIRIFYLD-- 227 Paramecium tetraurelia
4DHJ_I   236 ----------------------------RTa---APNGGWHYDIPsd--------------dQQ---------------- 254 Caenorhabditis elegans
Q0V4T6   291 ----------------------------RS----PGEEINRSFYA-----------------DPtdhqg----------m 311 Parastagonospora no...
EDN99907 231 ----------------------------RS----EGTQVNSHMFQaedpn--------gqptNP---------------- 254 Sclerotinia sclerot...
Q2H586   380 ----------------------------RS----PGPEVNTYRIPeean---------grhpSE---------------- 402 Chaetomium globosum...
Q7SI56   445 ----------------------------RS----PGSEVNTYSFPeeai---------sqptSP---------------- 467 Neurospora crassa
KIS69951 245 qappqtpl----------deefpaeqlhQStensSDPTCRASASIpvpgndaq--rtrsaaeHPdrcdvvr------fev 306 Ustilago maydis 521
Q4DPS6   224 ----------------------------GS----VGTRTTRHSFSgdss----------dtgDN---------------- 245 Trypanosoma cruzi
Q7XPN5   434 setdtpilnqhfiyprpeseegtmlgplNSheivSPESSGYHAARgelqnqpstsgsstnssTEalglqsigtsstpner 513 Japanese rice
Q5KB39   231 ----------------------------RSe--vGGKTINWVEFGkd--------------tSE---------------- 250 Cryptococcus neofor...
A0E9B0   228 --------------------------------------GNVSTFDatifq-------ipedaDS---------------- 246 Paramecium tetraurelia
4DHJ_I   255 ---IAPEI------------TLLYRPGHYDVIYK 273 Caenorhabditis elegans
Q0V4T6   312 sipNAHML------------RLLYRPGHYDILYK 333 Parastagonospora nodorum SN15
EDN99907 255 ---AGPII------------YLLYRPGHYDILYK 273 Sclerotinia sclerotiorum 1980 UF-70
Q2H586   403 ---LGPII------------HLLYRPDHYDILYV 421 Chaetomium globosum CBS 148.51
Q7SI56   468 ---LDPVI------------CLLYRPDHYDILYp 486 Neurospora crassa
KIS69951 307 eggQITEIg-----------TMLLRPGHYDLLVE 329 Ustilago maydis 521
Q4DPS6   246 ---THLVV------------TLLYRPGHYDLLYK 264 Trypanosoma cruzi
Q7XPN5   514 dgkGDRTIndlspaerrrlaILLYRPGHYDILCP 547 Japanese rice
Q5KB39   251 ---NARPL------------TLLYRPGHYDVVTK 269 Cryptococcus neoformans
A0E9B0   247 ---KSIFI------------NLLYRPGHYDILYP 265 Paramecium tetraurelia
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