Conserved Protein Domain Family
RAI16-like

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pfam10257: RAI16-like 
Retinoic acid induced 16-like protein
This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.
Statistics
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PSSM-Id: 370927
View PSSM: pfam10257
Aligned: 20 rows
Threshold Bit Score: 224.125
Threshold Setting Gi: 74858604
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5KIL0      83 CLEYFLKNDILAHLERLCEA--DRPH---GIKAEVVKSINNLVVLLSERFLVHNAVHRPLRRLlrscigdepee------ 151  Cryptococcus neo...
Q0U332      79 CLQFAAANQIYTAVSKIAAT--SHDE---GMVRDAVAFYNALIDSEEEDFLENDVFAVSLMNFin--------------- 138  Parastagonospora...
EDN07488    80 CHAFAATSQVYLTVTKLALF--SCDP---GVISKSAVLFNTLIDAEVDGIVDSRIFARALVDLv---------------- 138  Histoplasma caps...
Q4X096      81 CLAYAASSQIFVTITKVTLS--AYDGgqvGTLRAAAIFFNTLIDSEVDGVVDNRLFARALVDLv---------------- 142  Aspergillus fumi...
XP_663947  488 CLAYAASSQIFVTVTKLALS--SYDE---AMLRSATVLFNTLIDSEVDGVVDNRLFARALVDLv---------------- 546  Aspergillus nidu...
Q9VQK0     101 CLEFLLSENLLDKLYEWACTtgRYAN---AVRLEQLKLYELLVSHSRHQLLCHEPFLRPLLKI----------------- 160  fruit fly
Q17AI4     114 CLEHLLSENLLDKLYEWGVKtgRYAN---AVRLEQLKLYEQLVSHSRHQLLVHEPFLRPLLKI----------------- 173  yellow fever mos...
A7YY62      96 LLEFALREDLLTRVLTWQLQwdELGDgveERRAEQLKLFEMLVSEARQPLLRHGPVREALLIL----------------- 158  cattle
Q55D58      75 CLEFFLKNKILETLCLLGEH--DKPQ---GVRKLILQTITMLLSDLSLPLLPHMSVHRPICSLiktminkqqhlqqqlnq 149  Dictyostelium di...
CAF90709    39 ILEFVVMENVMERLFVWSLRr-EFTD---DMKVEQLKMYEMLVGQARQPLLHHKPILRPLMML----------------- 97   spotted green pu...
Q5KIL0     152 ----------kldgtrvfgaaGMANGMERgasNEDI------------------------EGDLVDLMCVLCSKMRAYPP 197  Cryptococcus neo...
Q0U332     139 -------------------rtVGSGSMGV---GEDI------------------------EADIVELLFGIAAKIRLQPE 172  Parastagonospora...
EDN07488   139 ---------------------CKAGSA-----GEEG------------------------EGRLVELLFGVANNIRLRPA 168  Histoplasma caps...
Q4X096     143 ---------------------RRADKH-----DEDV------------------------EGRLVELLFGVANNIRLQPS 172  Aspergillus fumi...
XP_663947  547 ---------------------RRADKK-----SADI------------------------EGRLVELLFGVANNIRLQPN 576  Aspergillus nidu...
Q9VQK0     161 ---------------------LASSQGEIf--PPDL------------------------EKRLVILLNQLCVVLMQNVH 193  fruit fly
Q17AI4     174 ---------------------LASSQNEIy--PPDV------------------------EKRLVILLNQLCVVLMQNVH 206  yellow fever mos...
A7YY62     159 ---------------------LDACGRPVp-sSPAL------------------------DEGLVLLLSQLCVCLAREPS 192  cattle
Q55D58     150 qqqqqqqqqnpttvttgstllLSSSTSSTtssSSAVtaqqieddrskllpigrvplqsndDSEFVSLLETLAMILIKYPN 229  Dictyostelium di...
CAF90709    98 ---------------------LSSCSGTA---APRV------------------------EAELVLLLNQLCCVLAKDPS 129  spotted green pu...
Q5KIL0     198 LLLIFFHDRGWAQSnnnvsqvdsnsnrarsptptthTTLSelptkTSSRATHQFEFLLFSYLLRFVHREGRLGDFARAGL 277  Cryptococcus neo...
Q0U332     173 ILPVWFTTASSDEN-----------------------GRLvnkkvDFAGVTQKEDFPLCYQLIDHVHHEGRIGDFARTGL 229  Parastagonospora...
EDN07488   169 ILPAWFYPKDHGNR----------------------KPELveagnEFAGATRKDDFPLFYLLIDYVHHEGRSGDFARTGL 226  Histoplasma caps...
Q4X096     173 ILPAWFAPRSDGQD----------------------KERQtnmgtEFAGATRTNDFPLFYLLVQYVHHAGRAGDFARTGL 230  Aspergillus fumi...
XP_663947  577 ILPAWFAPRTDD-------------------------EEQstgsvEFAGTMRTDDFPLFYLLVEWVHHAGRAGDFARTGL 631  Aspergillus nidu...
Q9VQK0     194 LLDLFFFSAQTQVQ-----------------------EQIlngnvAPPKSGTTTNFIIFSLLIPYVHREGSLGHQARDAL 250  fruit fly
Q17AI4     207 LLDLFFFSTAQQ-----------------------------------NGSGGHANFIIFSLLIPYVHQEGSLGHQARDAL 251  yellow fever mos...
A7YY62     193 LLEFFLQPPPEP--------------------------------------GAAPRLLLFSRLVPFVHREGTLGQQARDAL 234  cattle
Q55D58     230 LIGFFQENSFKQ----------------------------------------GENFIVFQGLLGHLWTHGSIGERARKAM 269  Dictyostelium di...
CAF90709   130 ILELFFHTSEDQ---------------------------------------GATNFLIFSLLIPFIHREGTVGQQARDAL 170  spotted green pu...
Q5KIL0     278 IFLFDIAfltpgEEGGEnlssgpgnngp---------------------------------------------------- 305  Cryptococcus neo...
Q0U332     230 LYIFESAs---kSLTLE--------------------------------------------------------------- 243  Parastagonospora...
EDN07488   227 LYIIETAs---rSKELD--------------------------------------------------------------- 240  Histoplasma caps...
Q4X096     231 LYLIETAs---rSKILE--------------------------------------------------------------- 244  Aspergillus fumi...
XP_663947  632 LYLIETAs---rSKDLE--------------------------------------------------------------- 645  Aspergillus nidu...
Q9VQK0     251 LLCMALSq---kNSNIG--------------------------------------------------------------- 264  fruit fly
Q17AI4     252 LLCMACPr----RLDRG--------------------------------------------------------------- 264  yellow fever mos...
A7YY62     235 LLLMALSa---gSPTVG--------------------------------------------------------------- 248  cattle
Q55D58     270 IQCLELIs---eVSTDSpesaltspsssttgsinnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnsnqed 346  Dictyostelium di...
CAF90709   171 LLIMSLSa---eNERVA--------------------------------------------------------------- 184  spotted green pu...
Q5KIL0     306 ----------dplqeardalGEFILDGDFAD-----------------------VMAAALG-AVYSLLPTKL-----QV- 345  Cryptococcus neo...
Q0U332     244 --------------------AWIVN-SDLPT-----------------------LMATGLG-ALYSQLSRHL-----P-- 271  Parastagonospora...
EDN07488   241 --------------------RWLIE-SDLAT-----------------------LMATGLG-ALYSQLNRKLtfsntGKn 275  Histoplasma caps...
Q4X096     245 --------------------RWLIE-SDLAT-----------------------LMATGLG-ALYSQLGSLSf----GTt 275  Aspergillus fumi...
XP_663947  646 --------------------RWLIE-SDLAT-----------------------LMATGLG-ALYSQLGSLGs----CLd 676  Aspergillus nidu...
Q9VQK0     265 --------------------TYIAQYSSICP-----------------------LLVTGLG-GLYSRLPNSIe------- 293  fruit fly
Q17AI4     265 --------------------TYIATYSSICP-----------------------VWFTRAGeGLYSRLPNQId------- 294  yellow fever mos...
A7YY62     249 --------------------CYIADHSYFCP-----------------------VLATGLS-ALYSSLPRKIe------- 277  cattle
Q55D58     347 nvstvlspkkqqnmlpqaqtQPLSNSTQLYPqdekieflhpdplsllnhlrfmnVMISELI-KTYNLLPKK--------- 416  Dictyostelium di...
CAF90709   185 --------------------KHVAENTFFCPvspsarmigfplsccltlslpaqVLATGLS-GLYSSLPTKLd------- 236  spotted green pu...
Q5KIL0     346 -----PSISSQEVPEeDnkNISSggmhlgsgmkrqdgedniQLSTDLHv-RTQLDLLLKLFGFLQDIIRRCNSpilyadp 419  Cryptococcus neo...
Q0U332     272 ------IILSLSDYSeMqsNAQA------------------ESFFGEDf-QNHLVTFLSYLTFWQDVLEHCRSt------ 320  Parastagonospora...
EDN07488   276 ----mPLIVALSDY------APA------------------ETASRPKl-GAHMDAFLSYLLFWQDTIDHCKSv------ 320  Histoplasma caps...
Q4X096     276 eeenlPHIVALSDHArHenALPP------------------QLD--S-----TMDSFMSYLLFWQDTIDHCKSa------ 324  Aspergillus fumi...
XP_663947  677 vepvvPHVISHSD------HAQQ------------------ETAL-PPalGSSMDSFMAYLLFWQDTIDHCKSa------ 725  Aspergillus nidu...
Q9VQK0     294 -------ISSIDWh----rITPD------------------DVTEIP-----ELTLFMNALEFCNAVVQVAHE------- 332  fruit fly
Q17AI4     295 -------IKTIDWy----rITTD------------------DVTELQ-----ELTLFMNSLEFCNAVVQVAHS------- 333  yellow fever mos...
A7YY62     278 -------VPGDDWh----cLRRE------------------DWLGVP-----ALALFMSSLEFCNAVIQVAHP------- 316  cattle
Q55D58     417 -------IQSSHYSIsGppISTE------------------NLN--------ILEYFKSRVSFCCSLSYIKQN------- 456  Dictyostelium di...
CAF90709   237 -------VPSEDWh----cLHRE------------------DWLQMP-----SLVQFLNSLEFCNAVIQVAHP------- 275  spotted green pu...
Q5KIL0     420 hsgavtvthvlggAIAGATLDAIHSSFLDNVLYPSLLECSSh-dGSSVAVLTYLDVLFSNLDDGPIVDRVLSFLL----- 493  Cryptococcus neo...
Q0U332     321 -------------EVRHTLIDHFQILFLQQLLYPSLLESSDadgGSSVAVLTYLRRILDALDHPELVNMILQYLLa---- 383  Parastagonospora...
EDN07488   321 -------------EVNDTLLDHFQVLFLQQLLYPSLLESSDvdgGSTSAVITYLCRILESIDQPDLVHRILHFLLa---- 383  Histoplasma caps...
Q4X096     325 -------------EVNGTLLDHFQVLFLEQLLYPSLLESSDvegGSTAAVLTYLHRILESIEQHDLVHRILHFLLa---- 387  Aspergillus fumi...
XP_663947  726 -------------EVVATLLDHFQVLFLEQLLYPSLLESSDvegGSTAAVLTYLYRILASVDQEDLVQRILHFLLa---- 788  Aspergillus nidu...
Q9VQK0     333 -------------MIKQQLLDFMYQGFIVPVLGPAILQTNI---DSQISAMSYLDLILRSITEPGLLRAFVRFLLdt--- 393  fruit fly
Q17AI4     334 -------------MIRQQLLDFLYQGFLVPVLGPAVLQTNV---ESQISAMAYLDLIVRSVTEPGLIQIVVKFLLde--- 394  yellow fever mos...
A7YY62     317 -------------LVQKQLVDYIHNGFLVPVMGPALHKTSV---EEMIASTAYLELFLRSISEPALLRTFLRFLLlh--- 377  cattle
Q55D58     457 -------------NIGEYVLKLWEESFLADTLGPNLLDTDE---GNSSTTMLYLKEILPLLEGP-ILEQTISFLLgginp 519  Dictyostelium di...
CAF90709   276 -------------DIRDQLVGYIYNGFLVPVLAPALHKLTL---EEVMTTTAYLDLFLRSVTEPALLQTLLSFILlh--- 336  spotted green pu...
Q5KIL0     494 ------------------------------DIDLSDtCMPLPAVNSKRERQETGAMRYVGRIPLKSTEYFASEGRFTLKD 543  Cryptococcus neo...
Q0U332     384 ------------------------------LKDYAS--TSPEAPRSPVAIKRRQSLMLLSG--PDQDDDRLNPSLFNLVD 429  Parastagonospora...
EDN07488   384 ------------------------------SSKAGEpAIKIPKSELRMSLSRRKSIDLLAS--FAEAAAKPSPELFNLVD 431  Histoplasma caps...
Q4X096     388 ------------------------------SPSDSQ-----PTSKVGMSSSRRKSLDVLAA--FSEGAARPSPSLFNLRD 430  Aspergillus fumi...
XP_663947  789 ------------------------------SPSGVD--VQAPEKKKDMSASRRKSLDVLAA--FSQEAARPSPTLFNLRD 834  Aspergillus nidu...
Q9VQK0     394 ----------------------------ekF-------DGERILDALVERLNSPDANLCMVTMALFDTLLGLHCEDLMLE 438  fruit fly
Q17AI4     395 ----------------------------ekF-------DGQRILDVLVERLNSNDTRLCMVSLSLFDTLLSLNCEDIMLE 439  yellow fever mos...
A7YY62     378 -----------------------------rH-------DTHTILDTLVARIGSN-SRLCMVSLSLFRTLLNLSCEDVLLQ 420  cattle
Q55D58     520 ihffnkttnansspvllknssssncittttTTINCRdDEDYFMKTTLIQRISSKNFIVSISALRLFSTLVGLRDFNTLYN 599  Dictyostelium di...
CAF90709   337 -----------------------------qH-------EGVHILDTLISRINTP-FQLGTVSLALFRTLIGLSCEDVMLQ 379  spotted green pu...
Q5KIL0     544 LILDNL 549  Cryptococcus neoformans
Q0U332     430 LVLGST 435  Parastagonospora nodorum SN15
EDN07488   432 -----L 432  Histoplasma capsulatum NAm1
Q4X096     431 LALLGL 436  Aspergillus fumigatus
XP_663947  835 LVLLGL 840  Aspergillus nidulans FGSC A4
Q9VQK0     439 LLLKFM 444  fruit fly
Q17AI4     440 LALKYL 445  yellow fever mosquito
A7YY62     421 LVLRYL 426  cattle
Q55D58     600 LILIHL 605  Dictyostelium discoideum AX4
CAF90709   380 LILRYL 385  spotted green pufferfish
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