5A5T


Conserved Protein Domain Family
Paf67

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pfam10255: Paf67 
RNA polymerase I-associated factor PAF67
RNA polymerase I is a multisubunit enzyme and its transcription competence is dependent on the presence of PAF67. This family of proteins is conserved from worms to humans.
Statistics
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PSSM-Id: 402046
View PSSM: pfam10255
Aligned: 64 rows
Threshold Bit Score: 290.662
Threshold Setting Gi: 124464776
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A5T_L       152 QRFESYYNYCNLFNYILNa--dGPA------------------------------PLELPNQWLWDIIDEFIYQFQSFSQ 199
XP_001616139 105 DRKNSWDNYKCLLNFISSic-sDPSgdt------------------------ndnVLVMPNVWIYDFLSEYIYQYQSMCH 159 malaria parasit...
CAG25361     104 DRKNSWDNYKCLLNFITTic-tDLSgds------------------------ndnVLVMPNVWIYDFLSEYIYQYQSMCH 158 Plasmodium falc...
Q7RAI1       104 DRKNTWENYKCLLNFISSic---tDndg------------------------ndnVLVMPNVWIYDFLSEYIYQFQSMCH 156 Plasmodium yoel...
XP_001611504 112 DRLDSWEKYSKLLAYFIDel-eKGEgsd------------------------tlnSLVIPASWVWDILDEFVYQLQECCR 166 Babesia bovis T2Bo
Q4UDV1       112 DRVDSWNKYVRLLTYFIEec-nKPEgse------------------------glsGLTIPSSWVWDMLDEFVYQLQESCH 166 Theileria annulata
Q4N5P3       112 DRVDSWNKYVRLLTYFIEec-nKPEgse------------------------glsGLTIPSSWVWDMLDEFVYQLQESCH 166 Theileria parva
A0C6C9       147 TSIESWQNYQLLFAALQQkq---------------------------------niDLPLPPSWIWDILDEYVYQFYVSSR 193 Paramecium tetr...
XP_002292053  90 NRIEGWHTYRQLFDLLLSeapeEEGgadae--------------------kkkkeSLYLVPEWCFDILHEFLYQFQGFCQ 149 Thalassiosira p...
XP_002140778 157 DRVASWKNYVKLFGFLLLke-fSKSnsqpikitnslaatfeqygvklqdnslpndRILLPSEWIYGIMDEFVYQLQDTCR 235 Cryptosporidium...
5A5T_L       200 YRCktak------------------kseEEIDFL-R------SN---PKIWNVHSVLNVLHSLVDKSNINRQLEVYTSG- 250
XP_001616139 160 YKL-------------------------KILKEPeEnkegidFLikhSDVFESSIVLEVLHSLLLKAEFVTLSEEERAIf 214 malaria parasit...
CAG25361     159 YRL-------------------------QLLKDLeKneegilFVtrnTEVFESSIVFEVLHNLLLKGEFSTLPLEEKSTf 213 Plasmodium falc...
Q7RAI1       157 FKI-------------------------ELLNFPeEntkgieFVvnnPDVFESNIVLEVLHSLLLKGEFTTLPEDEKITy 211 Plasmodium yoel...
XP_001611504 167 WRSrisrsd--------------skalvSDAKI--------------HSIWKVPTALEMLQRLANNTVFQNMSHPSQRDg 218 Babesia bovis T2Bo
Q4UDV1       167 WKVrfcsstgsigy---daaetkaeieqRIQET--------------MGIWCVPVALELLHELANNPVFKSACQSS---- 225 Theileria annulata
Q4N5P3       167 WKIrfcsstedqrncgylvcssssraltRVGKQ--------------SNVQICLSVFKGCAFGYNKSELPTRIFR----- 227 Theileria parva
A0C6C9       194 WRKll---------------------knDEITQVkNi----------QDYWNLEEILKTLEAFYSQR------------- 229 Paramecium tetr...
XP_002292053 150 FRTttycaaakfssdndgenkaipshvaDAIDALnS------NR---DA-WAVETVLYYLHRLVAVG------------- 206 Thalassiosira p...
XP_002140778 236 YTV-------------------------RATHASnEysqddrVNkidQNIWRCDITLQLFQTIIDESKIRSILSGSEETq 290 Cryptosporidium...
5A5T_L       251 GDPESVAGEyGRHSLY---KMLGYFSLVGLLR-----------------LHSLLGDYYQAIKVLENIELN-KKS-MY--S 306
XP_001616139 215 VH---NVFHvNNEDLTs-rYQFAYFACCVLLK-----------------VYVLMGDYYTALKIISYIELS-HKA-LY--W 269 malaria parasit...
CAG25361     214 VN---NIYNiNNEEINs-kYQFAYFACCILLN-----------------LYVLIGDYYTALKIISNIELN-HKA-LY--W 268 Plasmodium falc...
Q7RAI1       212 VN---NIFNiNNEELTs-kYQFSYFSCCILLN-----------------VYVLLGDYYSALKIISNIQLN-HKQ-LY--W 266 Plasmodium yoel...
XP_001611504 219 ---------lEAAGLS---FQLGYFASISLVR-----------------LHVLLGDYHTSVRTATSIEIS-SKF-LY--W 265 Babesia bovis T2Bo
Q4UDV1       226 -----KDLNlDTTSLN---YQLGYFASICLLR-----------------LHVLLGDYYTSLTMASNVDLS-PRS-LY--W 276 Theileria annulata
Q4N5P3       228 -----INLLiETSCVT---WRLLYFTDNGLKRgfipqkfvledsslqchTHLLPG-----------VRVHdAKV------ 282 Theileria parva
A0C6C9       230 -----------NSAVQntfQYLAYYSYLATAK-----------------LQVMSGNFNAAYTMLSQIQHS-E---LIiyS 277 Paramecium tetr...
XP_002292053 207 -------SGsNASATY---RYLAILSLVTISR-----------------LECLLGDYKAAISALDV-----SAEeLV--N 252 Thalassiosira p...
XP_002140778 291 VETALLSQTqDTIPLR---YQLGYFSMLCLVR-----------------IHVLLGDYYTAIEVADFIDSQlLRT-LL--W 347 Cryptosporidium...
5A5T_L       307 RVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRT--KSm--FQ-----RTTY-KYEMINKQNEQMHALLAIALT 376
XP_001616139 270 KVTLCHISVFYHIAFCYLMLRRYNDCIKVLSQILIYLSKQ--KVhlsN------QQRY-QQSQIHKLIDKMYFIVIICHS 340 malaria parasit...
CAG25361     269 KVTLCHLSIFYNIAFSYMMLKRYNDSIKVLSQILIYLSKQ--KIhvsN------QQKY-QQNLIHKLIDKMYLIIIICHS 339 Plasmodium falc...
Q7RAI1       267 KVILCHINIYYNIAFCYMMLKRYNDSIKILSQILIYLSKQ--KAhisN------QQKY-QQSLINKLIDKMYLIAIICHS 337 Plasmodium yoel...
XP_001611504 266 KVPSYYVSLFYHLGFAYMMLRRYSDCIKVLSQILIFLTKQ--RTyl-------aSQSY-QQGSMAKLAEKMYLMLILCHT 335 Babesia bovis T2Bo
Q4UDV1       277 KIPACNVTLIYYLGFAFMMLRRYNDAIRILSQLLIFLTKQ--RSyl-------vSQSY-QQSAMSKQTEKMYLIIIICHV 346 Theileria annulata
Q4N5P3       283 -LPIIPI----------IMCRRYNDAIRILSQLLIFLTKQ--RSyl-------vSQSY-QQSAMSKQTEKMYLIIILCHV 341 Theileria parva
A0C6C9       278 KSGGAYQSLFSYAGFCFLLNKEYKKANLTLTLIVNYFNKY--KQl--------yTKSY-QYDSLIKQHEKILALLAVTSI 346 Paramecium tetr...
XP_002292053 253 GVFPARLSLAYHAGVSYLMLRRYKDAVGVLGGICLFMQRGfkTG----Q-----LRKIpGSEQFNKLFDRMIALLAILTH 323 Thalassiosira p...
XP_002140778 348 KVPTAYVSYLYYLGFAYMMLQRYIDAIRIFQQSTVSFASS--TVgssSLpgnqgPSSY-QHDAIGKCVDRMSWLMLFCQL 424 Cryptosporidium...
5A5T_L       377 MYP-M-------RIDESIHLQLRE---KYGDKMLR-MQKGDPQvYEELFSYSCPKFLSP----VVPny-dSVhpnyhK-- 437
XP_001616139 341 LSN-T-------RLDETILQNIKE---NYSGKFYAlLQTTNEQaYADLFYKVAPKFIDP----LSNisfqLLasfenVqn 405 malaria parasit...
CAG25361     340 LTN-T-------RLDETILQNIKE---NYSGKFYA-LQSANEQtYAELFIRVAPKFIDP----LSNisfqILsnfqnIqn 403 Plasmodium falc...
Q7RAI1       338 LCN-T-------RLDETILQNIKE---NYSSKFYS-LQSANEQaYTDLFYRVAPKFIDP----VSNisfqLLtnfenTqn 401 Plasmodium yoel...
XP_001611504 336 TTK-I-------RLDETILQTIKE---QYANRFYQ-LQGENEEaFRDAFLKSCPKFIDA----ASGsg-sTTdeesdItg 398 Babesia bovis T2Bo
Q4UDV1       347 TTR-I-------KLDETVLQTIKE---QYANKFYQ-LQVDNEDsFRDVFLKACPKFIDP----AVPtl-kLTeas----- 404 Theileria annulata
Q4N5P3       342 TTR-I-------KLDETVIQTIKE---QYSNKFYQ-LQVDNEDsFRDVFHKACPKFIDP----AGPsl-kLTesp----- 399 Theileria parva
A0C6C9       347 FYP---------ELEDNIITLLKEsrnKLFEKYEK-ILKYDQQlIGEVFLQSCPKIINTikniKEFqteqELnp------ 410 Paramecium tetr...
XP_002292053 324 ICPtA-------ILDDSIASIVRD---KHANNLSK-IESGE-EgYEDLFVFACPKFVNA----AVPdy-aQAlkpgaEmm 386 Thalassiosira p...
XP_002140778 425 LSY-GsnssninRLEETLSHQGDR---KLASTFVS-ISSDISN-WKELLLKVSPRFISS----CIP----QFlheedSnk 490 Cryptosporidium...
5A5T_L       438 -----EPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLtEQE--------------------------- 485
XP_001616139 406 qtynsDPMTTQLNIFLKDVSYQKKAFHFISYAKLYHNIQLRKLSSLMNY-GQQrrpaegdtasqenhlg----------- 473 malaria parasit...
CAG25361     404 qtyssDPTNRQLAIFLKDVSYQKKAFYFISYAKLYHNIQLKKLANLMNY-NELinndde--------------------- 461 Plasmodium falc...
Q7RAI1       402 qpynsNPTLRQLSIFLKNVTYQKKTYHLMSYVKLYHNIQINKLGNLMNY-QEEdn------------------------- 455 Plasmodium yoel...
XP_001611504 399 g-slnEPVQRQLNLFLKEIGNQRRVDEIYSFAKLYHNISLEKLAALMKLged---------------------------- 449 Babesia bovis T2Bo
Q4UDV1       405 --svnEPLQRQVQIFLEEINKQRKVNEIYSYAKLYHNISLKKLGVLMNLgdd---------------------------- 454 Theileria annulata
Q4N5P3       400 --tvnEPLQRQVQIFLEEINKQRKVNEIYSYAKLYHNISLKKLGVLMNAgdd---------------------------- 449 Theileria parva
A0C6C9       411 ----nETIIEVKDKLLKEILEAKRINDVEQVLSLYNQITFEHFNKLL--------------------------------- 453 Paramecium tetr...
XP_002292053 387 p-ygqDAYKLQVHHFMNEMTAHQTLRKMRSYMSLYTSIGVEKLASFNDMkVEE--------------------------- 438 Thalassiosira p...
XP_002140778 491 i-dfnESQNRQMTVFTPSVQIYELSCMIRSFTKLYNNLNVETLASLMHV-AKKgvnqksrsvikecdekldsktnttnvv 568 Cryptosporidium...
5A5T_L       486 -----------------FRIQLLVFKHKM-KNLVwtsg---isaLDGEfqSASEVDFYIDKDMIHI-ADTKVARRYGDFF 543
XP_001616139 474 --evqkgepspdealalVSADIMCVKNSG-RQLVwkdgp-lykgEVVTsvFGSAFDFYIDMDILNI-KTRAQQKIFIDYF 548 malaria parasit...
CAG25361     462 -----------heqeqnVSSDIMCVKNCS-KQLIwkegp-lytgDIINsiFGNSFDFFIDLDIVNI-KTRAHQKIFIDYF 527 Plasmodium falc...
Q7RAI1       456 ---------------dnVYCDIMCVKNYN-RQLIwkegp-lysgEITTsiFGNTFDFYIDIDILNI-KTRAQQKFFIDYF 517 Plasmodium yoel...
XP_001611504 450 --------------relVRSYVLSVKHQT-RQFAnss----sggDVIPgtAEGDIDLYIDQNILYI-KSKRSQKLFVDYF 509 Babesia bovis T2Bo
Q4UDV1       455 --------------pelLRSQILCAKHHV-RQFVsnsfs-lyhtNLLQtfGDRD-DLYIDQNVLHI-KSKKNQKIYAEYF 516 Theileria annulata
Q4N5P3       450 --------------pevLRSQILCAKHHV-RQFVsnsfs-lyhtNLLQtfGDRD-DLYIDQNVLHI-KSKKNQKIYAEYF 511 Theileria parva
A0C6C9       454 -----------------PQKYVQLYIDRNsVALNensf--estiLSKFwqKSKLLEIEIKNNIIHV-KEVQVNQ---RDF 510 Paramecium tetr...
XP_002292053 439 -----------------FEPWLTCFKHKV-RQLErge-------ggDKmgTAMDIHYYVGENLVHV-DEAEKVRRFETFF 492 Thalassiosira p...
XP_002140778 569 egnainddlkphnpadiARSQIMSIKNRSgRQIIwkpgtsllggEIVS--ISGDFDLLLDVDTIHImEGKQVDKFFGDVF 646 Cryptosporidium...
5A5T_L       544 IRQIHKF 550
XP_001616139 549 LHQINMC 555 malaria parasite P. vivax
CAG25361     528 VHQINMS 534 Plasmodium falciparum 3D7
Q7RAI1       518 IHQIGMC 524 Plasmodium yoelii yoelii
XP_001611504 510 LQQINRC 516 Babesia bovis T2Bo
Q4UDV1       517 LQQINKC 523 Theileria annulata
Q4N5P3       512 LQQINKC 518 Theileria parva
A0C6C9       511 INQLAQM 517 Paramecium tetraurelia
XP_002292053 493 MKQIANn 499 Thalassiosira pseudonana CCMP1335
XP_002140778 647 AKQIIKA 653 Cryptosporidium muris RN66
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