Conserved Protein Domain Family
Pacs-1

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pfam10254: Pacs-1 
PACS-1 cytosolic sorting protein
PACS-1 is a cytosolic sorting protein that directs the localization of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef.
Statistics
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PSSM-Id: 402045
View PSSM: pfam10254
Aligned: 31 rows
Threshold Bit Score: 396.295
Threshold Setting Gi: 75014314
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q95R71       343 LLDQLSRVFAGEDSaIPEVVTIISPPEalggsalLAKlvTLFANSFkPAFVPQNTAEVKAVLQALMAKIQKYCNSNAKPP 422  fruit fly
XP_002401914 471 VLDQLGQLFAGDEA-VPDRLLLVEAPW-------LAT--ALQRAALpGVLSLAHGADLKAALAALVSRIQKFCNCNSRAP 540  black-legged tick
XP_003247003 456 LMEQLSKVLPPEDK-MPEVLCLIHYADplg--cqLAS--KLQNYQF-KVITPAGLADVRATFVCIINKIQKYCNSNPKPP 529  pea aphid
EEB13376     466 VVEQITKILGSDDS-LPDHLLIISSNDpqg--slLAS--RLQERQL-KVLPVVSTSEIRLTLTYLVNKIQKFCHSSAKPP 539  human body louse
XP_016843431 452 LVEQLSRVLP-DDS-LPESVALVSLSDpgg--avLAA--RLQERNL-RVLTTASPADVRATFTCLIARIQKFCNSSAKPP 524  jewel wasp
EGI64595     491 LVEQLSRVLP-DDS-LPEAVSLISIADpgg--avLAA--KLQERNH-KVLTPASPADIRATFTCLVTRIQKFCNSSAKPP 563  Panamanian lea...
EFX79929     520 LLEQLVRCMPADDA-LPDHVVMVSGADlqg--cnLAG--RLAERQQ-RAVCTGGVADVRATIACLVSKIQKFCNCSAKPP 593  common water flea
Q17EX1       556 LLEQLSRIFTTEESqLPDVVTIIGPPEasssstlTPRlvSLISSTFrPTFSPNNTAEVKAITQALMNKIQKYCNSTAKPP 635  yellow fever m...
EEN69247     523 LYDQLAHIIPSDEH-LPDSVVLVNTAEwqaqtqlLAQ--KLQELHH-RVVCTSSQADVNATFSFLVAKIQKL-------- 590  Florida lancelet
ESO06793     456 fMEQMSSILSCDHN-SPEVIVMl-----------LAQ--ALQSTKH-RTICTCSPSEVRTIVSTIASKIQKCTNKSLTQE 520  Helobdella rob...
Q95R71       423 HTVKVLLIGGDWLQGATLRHYVELMGVRPPDWLNHLRFYLVPVGGSCgsV--ARHLSQMDQAYAV--MFGSDNWTQ-LCE 497  fruit fly
XP_002401914 541 LTVRVGLLGSDPFLHSVVRLYVEHFSTKPPEWQAYLRFFFVPTGGSP--V--ARYLSSVDNCYAS--LFGDSSWRE-LVE 613  black-legged tick
XP_003247003 530 SQMKILLAGSDSFVNYVLRQYVEQLSFKPPDWMNYIKFYIIPLGINT--L--SRYLGTVDSYYGTtfLFKEDYWKE-QLE 604  pea aphid
EEB13376     540 NTIKLMVVGSDAFINNILRQYVDQLSQKPPEWQGFIKFLIVPLGSSS--I--SRYLASVDSTYGA--YFAGEKWRD-LSE 612  human body louse
XP_016843431 525 APIKVVIAGGDSFINTVLRHYVDLLSFRPPDWMHYLRFLVVPLGSNT--L--SRYLASIDARYAL--LFGDE-WRE-LAE 596  jewel wasp
EGI64595     564 APIKVIIAGGDSFINAVLRHYVDLLSFRPPDWQNYMKFLVVPLGSNT--L--TRYLSSIDTKYSK--LFGDE-WKE-LLE 635  Panamanian lea...
EFX79929     594 PAVKVVLMGPDSYVNSVLRCYVEQFSSKPPDWKNYLKFYIVPL------VtnSGYLASLDRYYNV--NFVSDSWRE-ALD 664  common water flea
Q17EX1       636 TTVKVLLVGGDWLQGAVLRHYVELLGIRPPDWVNHIRFYIVPIGSCG--V--ARYLSLIDSSYSS--MFGTENWQQ-ICD 708  yellow fever m...
EEN69247     591 ----VVLVGGESYVHAILRPYVDQFSQKPPDWQNHIKFYIVPLGGHV--L--ARYLASIDSKYNA--TFNDQTWKE-AFE 659  Florida lancelet
ESO06793     521 LPIKVAIVGGDKYISSVLRPYVELFSNKSSDWINYIRFLVVPLGPSI--I--GKNLSSIDNRYAG--LFNDSAWKDnVFE 594  Helobdella rob...
Q95R71       498 RAAAtaaavsavttvnatalttnladaagvaksDIAELVQRIQRYLLAAGPCTQIPIAEAMVNYK----DEDSCQIFVPF 573  fruit fly
XP_002401914 614 RGSP-----------------------------EAPELADRVADYLSGAHSCLQLPVAEAMVTYKghssDDESTQVFIPF 664  black-legged tick
XP_003247003 605 CG-------------------------------DGTDIIGKIQNYIMEASNTIQLQIAEAMLSYKekssDDEALQTFIPF 653  pea aphid
EEB13376     613 R--------------------------------EINEVVNKIGLYMNNGTSTIFLPVAEAMLTYKekssDDESSQIFVPF 660  human body louse
XP_016843431 597 REGA-----------------------------NASESAARVVEYLASSGTTLQLPIAEAMVTYRe---tDDSSQIFVPF 644  jewel wasp
EGI64595     636 REGG-----------------------------GSSECAARASEYLVTANTILLLPIAEAMVTYRe---tDDSSQIFIPF 683  Panamanian lea...
EFX79929     665 RPAEkmla----------------------asiNGGGVIHRLGRYLTSNGCTVQVPIAEAMITYRepnsEEESTQVFIPF 722  common water flea
Q17EX1       709 RAANlesa---------------------qtkiESAEIISRIQRYLHSSGPCTQVPIAEAMVNYR----DEDSCQIFVPF 763  yellow fever m...
EEN69247     660 KPDSst-------------------------qpDYQEVIGKISSFVLSANVTHQLPIAEAMLTYKakvtDEESTQTFIPF 714  Florida lancelet
ESO06793     595 RFDFsnrf---------------------nqsmDIGEVATRIVKYLNNARHMIQLPLSEAILTNKdk-gIDDSSHLIVPF 652  Helobdella rob...
Q95R71       574 VSDVRI-----GYLDA-Q-----------ASLDLEENaagsn--avgsGLGSGSASSSAiPigsqsspnvhgvvSGSPPQ 634  fruit fly
XP_002401914 665 ISVKKRkkfaeGEMTKpGc----------YAVDLEEA-----------LPGSSPPGGPMeRe------------STTPPS 711  black-legged tick
XP_003247003 654 VNDVRI-----CSGDTaS-----------GSNDTDDQcsiii--drksILD-----------------------KTTPPN 692  pea aphid
EEB13376     661 VNDVRL-----GSMDSaSg----------ASVDLDDMqatc----gssPP------------------------KITPPS 697  human body louse
XP_016843431 645 INDVRV-----GCPDSsAs----------ASVDLDEGgvtt----sgsPPSLPPASLPLgPpp----------gRLTPPS 695  jewel wasp
EGI64595     684 INDVRV-----GCPDSsSs----------TSVDLEESnvsm----sgsPPSLPPPSLPVpTp-----------gKLTPPS 733  Panamanian lea...
EFX79929     723 VSEVRI-----GFAESaAavmaaaaamtpGSVDAEDGqqlsn--tgasSGPL----------------------SGSPPH 773  common water flea
Q17EX1       764 ISDVRI-----GCLEGpQ-----------LSLDLEETmtqssqqssdrILSSSPPQSG----------------RASPPA 811  yellow fever m...
EEN69247     715 VGDVRV-----GSSESaNl---------sVSMDMDDGvsgsp--qlasGLTATPTSTSQqAikd-------mkeTATPPT 771  Florida lancelet
ESO06793     653 LGEVRL-----GVMDVgNtsn-----ifsSLIDYDETsna------naSLSNSPPQSSHmIshmtnmdkvkeniSHTPPE 716  Helobdella rob...
Q95R71       635 ----QQSLGRISPPLQTPPSSasshrerntseslstpssvqqqsfsgalaaaEAVELQVDYWPLVRPGEGHAKESkggls 710  fruit fly
XP_002401914 712 ----SPSMSSAGLAPAGCVST-------------------------------SAMDLQLDYWTLGPSARKGAEPS----- 751  black-legged tick
XP_003247003 693 ----SPNIGMQYLPPPTKQVNwe---------------------------lcEPLELQLDYWLVPNTNKEVTTRGnepss 741  pea aphid
EEB13376     698 ----SPNVNSMHITNHSRESNl-----------------------------vEPLELQIDYWTSNKSSEAKEVGKgkd-- 742  human body louse
XP_016843431 696 ----SPNVGQPRDGW-------------------------------------EPVELQLDYWGKPALGEKG--------- 725  jewel wasp
EGI64595     734 ----SPNVGQPAREGW------------------------------------EPVELQLDYWS----------------- 756  Panamanian lea...
EFX79929     774 ----QSSVMETSSTPGA-----------------------------------ESVELQVDYWFLATMAQAVKREKpgpae 814  common water flea
Q17EX1       812 pitpAPIMQHQSNSSGSPQ---------------------------------ESVELQVDYWPLARPILDAKEKSqskgq 858  yellow fever m...
EEN69247     772 ----S-TLGSPGQMPQSPSSQt------------------------------EVLDLQIDYWLSSPPREGGKEKEkdkk- 815  Florida lancelet
ESO06793     717 ----SNNFLSTPTTTTTASSTttaa------------------------qniDAFNLQVDYWLMSGTSSQSSNATsnlpt 768  Helobdella rob...
Q95R71       711 k----------------------gsdaggKNSIKSTFRNLQV-----WRLP-----------QHAqQLGDMfNGLTVSFA 752  fruit fly
XP_002401914 752 -----------------------------KLTLKAWFRSVQArlhscSRRK-----------MVGkGVEALgPSLTLNYV 791  black-legged tick
XP_003247003 742 ------------------------krvdtKFTLKTGFKSLHI-----SRLF-----------LTNeEPLAF---FTVSYI 778  pea aphid
EEB13376     743 ---------------------------pnKSTLKTNFKAVQI-----QRIP-----------SPGeQPGSY---LLMNYI 776  human body louse
XP_016843431 726 -----------------------------KSSLRQAFRVLHV-----QRLP-----------AFGePPGQS---LYMNYL 757  jewel wasp
EGI64595     757 -----------------------------KQYVTSSFQSVAC-----AKTS-----------LIRrSSRTS---LVYEFH 788  Panamanian lea...
EFX79929     815 -------------------------qssvKYTVKAGFRWIVV-----QRLPhsnvsssttasSSGsDASSL---FTMTFG 861  common water flea
Q17EX1       859 -------------------------dqsgKNSIKSTFRHLQV-----WRLP-----------LAPnNGEYT-NGLTLSYA 896  yellow fever m...
EEN69247     816 --------------------------emtKGTVKTSVRWLQV-----NRLP-----------VSGdVSGSS-GTLTMVLV 852  Florida lancelet
ESO06793     769 nlfnsdlksdlltnitssasgkflskkdlKCSLKMMFRSVKI-----FRNSglqlsgdgsllAGGsNAG-----LSMVVV 838  Helobdella rob...
Q95R71       753 TKEKKQKq----------------IMRLGkKKDKERDLE-KEQCVEGVARLICSPKQSHPVpLRVYIDGTEWTGVKFFQV 815  fruit fly
XP_002401914 792 TKEKKQK-----------------IMRLGkKKERESDRDaRCQLVEGVHRLICSCRNLQAP-LKVTIDSVEWTGVKFFQL 853  black-legged tick
XP_003247003 779 -KEKKQK-----------------IMRLGkKKEKEKDLDpKNQVIDSVLRLICSPKTQHFP-LTITIDGYEWSGVKFFQL 839  pea aphid
EEB13376     777 TKEKKQK-----------------IMRLGkKKEKERETEnKNQQIEGVTRLICSPKTQALP-LKVSIDGVEWTGVKFFQL 838  human body louse
XP_016843431 758 TKEKKQK-----------------IMRLGkKKEKEKENEpKSQQVDGVTRLICSAKTHNIP-LRVSIDGTEWYGVKFFQL 819  jewel wasp
EGI64595     789 DKREKTKnnvqyikstlkencplsVMRLGkKKEKEKENEpKSQSVDGVTRLICSAKTHNIP-LRVSIDGTEWYGVKFFQL 867  Panamanian lea...
EFX79929     862 LKEKKQK-----------------IMRLGkKKEKEKESEsKSQVVEGINRLVCQAKTHHSL-LKVVIDGVEWNNVKFFQL 923  common water flea
Q17EX1       897 TKEKKQKs----------------VMRLGkKKEKDRDAE-KEQCVEGVARLICSPKQSHPVpLRVYIDGTEWTGVKFFQL 959  yellow fever m...
EEN69247     853 TKEKKQKkayqlt-----thhlnaVMRIG-KKAKDKEAEsKSQTIEAVNRLICTSKSQSSP-LKVTIDGSDWSGVKFFQL 925  Florida lancelet
ESO06793     839 TREKKQK-----------------IMRIG-KRSKESELN-KSQQIDGISRLICTSRSQNHP-LNVTIDGVDWSGIKFFQV 898  Helobdella rob...
Q95R71       816 SSQWQTHVKNFPIALI 831  fruit fly
XP_002401914 854 SSQWQTHIKYFPVGLY 869  black-legged tick
XP_003247003 840 SSQWQTHIKHFPVAVY 855  pea aphid
EEB13376     839 SAQWQTHIKTFPVALF 854  human body louse
XP_016843431 820 SAQWQTHIKNFPIAML 835  jewel wasp
EGI64595     868 SAQWQTHIKTFPIALL 883  Panamanian leafcutter ant
EFX79929     924 SSQWQTHIRHFPVALF 939  common water flea
Q17EX1       960 SSQWQTHIKNFPIALV 975  yellow fever mosquito
EEN69247     926 SAQWQTHIKHFPVGLF 941  Florida lancelet
ESO06793     899 SSQWQTHIKYFPVLIF 914  Helobdella robusta
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